Article
Horticulture
Jiawen Zheng, Quansheng Ying, Chunying Fang, Nan Sun, Menglu Si, Jing Yang, Biao Zhu, Yong-Ling Ruan, Zhujun Zhu, Yong He
Summary: The study found that under waterlogging conditions, watermelon cultivar 'YL' exhibited higher activity of alternative oxidase compared to 'Zaojia8424', leading to more stable respiration levels and reduced oxidative damage. Inhibition of the AOX pathway by salicylhydroxamic acid exacerbated growth inhibition and promoted oxidative damage accumulation in both cultivars.
SCIENTIA HORTICULTURAE
(2021)
Article
Pharmacology & Pharmacy
Fei Liu, Longhui Yuan, Lan Li, Jingchao Yang, Jingping Liu, Younan Chen, Jie Zhang, Yanrong Lu, Yujia Yuan, Jingqiu Cheng
Summary: Senescence of bone marrow mesenchymal stem cells (BMSCs) is a leading cause of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is associated with BMSC senescence-mediated bone degradation and mitochondrial/heterochromatic disturbance. S-sulfhydration of cysteine residues enhances SIRT3 activity. The underlying mechanism of SIRT3 S-sulfhydration on mitochondrial/heterochromatic homeostasis in BMSC senescence is unknown. The study demonstrates the role of SIRT3 S-sulfhydration in stabilizing heterochromatin and mitochondrial homeostasis in counteracting BMSC senescence, providing a potential target for the treatment of degenerative bone diseases.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Frederic Bouillaud
Summary: Succinate dehydrogenase (SDH) is a key enzyme in the tricarboxylic acid cycle and mitochondrial respiratory chain. Certain fungicides that target SDH have been shown to inhibit its activity in both humans and non-target organisms. In this document, the focus is on the metabolic consequences of SDH inhibition in mammals, particularly the liver. The solubility of these fungicides in lipids suggests that diet composition may affect their absorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Rui Huang, Canying Li, Mi Guo, Hengping Xu, Shuran Zhang, Miao Wang, Yonghong Ge
Summary: The current study found that dipping `Qiujin' apples in caffeic acid significantly inhibited respiratory rate, ethylene release rate, and hydrogen peroxide accumulation. It also increased the levels of reduced glutathione and ascorbic acid in the apples. Caffeic acid improved the activities and gene expressions of several key enzymes in the fruit, and suppressed senescence after harvest.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Fisheries
Feichao Du, Chaoyang Hu, Xue Sun, Liuquan Zhang, Nianjun Xu
Summary: The addition of trisodium citrate (TSC) was found to significantly increase astaxanthin accumulation in Haematococcus pluvialis under high light stress by up-regulating the expression of genes involved in TCA cycle, glucose metabolism, astaxanthin biosynthesis, and fatty acids metabolism, as well as changing the expression of genes involved in ROS scavenging and cell wall biosynthesis. These findings provide new insights into the mechanism of TSC-induced astaxanthin biosynthesis in H. pluvialis.
Review
Biochemistry & Molecular Biology
Junichi Fujii, Tsukasa Osaki
Summary: When NOS2 expression is induced in M1-polarized macrophages, large amounts of nitric oxide (center dot NO) are produced, which can lead to both inflammation aggravation and elimination of radical-mediated damage. The reaction of center dot NO with superoxide can be toxic, but it can also terminate radical chain reactions and suppress ferroptosis. center dot NO is involved in metabolic remodeling and regulates the defense systems in M1 macrophages.
Article
Plant Sciences
Qian Cheng, Guoying Zhao, Liu Yang, Asma Amdouni, Bangbang Mu, Chaofei Ye, Yuting Zhao, Xiaolin Cheng, Xing Cui, Peiyu Zhao, Hanfeng Zhang, Yu Ma, Yuan-Qing Jiang, Bo Yang
Summary: In this study, the researchers found that BnaMPK1 in oilseed rape acts as a positive regulator of ROS- and JA-dependent leaf senescence by promoting cell death and phosphorylation activity.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Review
Biochemistry & Molecular Biology
Ke Cao, Jie Xu, Wenli Cao, Xueqiang Wang, Weiqiang Lv, Mengqi Zeng, Xuan Zou, Jiankang Liu, Zhihui Feng
Summary: Mitochondrial succinate dehydrogenase (SDH) is an enzyme complex that plays a crucial role in regulating mitochondrial metabolism and human health. Recent studies have revealed the dynamic involvement of SDH assembly process in various diseases. Perturbation of SDH assembly in different tissues can lead to distinct pathophysiological changes, highlighting the importance of understanding the intricate SDH assembly process in human health and diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Francisco Javier Sanchez-Garcia, Celia Angelica Perez-Hernandez, Miguel Rodriguez-Murillo, Maria Maximina Bertha Moreno-Altamirano
Summary: Host cell metabolism is crucial for viral replication and infection, with the tricarboxylic acid cycle playing a key role in providing energy and biomolecules. Viral infections may induce host inflammation and promote the synthesis of anti-inflammatory and anti-microbial substances. The TCA cycle is essential in viral pathogenesis and anti-viral immunity, and recent research is exploring its role in virometabolism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Peripheral Vascular Disease
Hewang Lee, Xiaoliang Jiang, Imran Perwaiz, Peiying Yu, Jin Wang, Ying Wang, Maik Huttemann, Robin A. Felder, David R. Sibley, Brian M. Polster, Selim Rozyyev, Ines Armando, Zhiwei Yang, Peng Qu, Pedro A. Jose
Summary: Overproduction of reactive oxygen species (ROS) is important in hypertension, while dopamine D-5 receptor (D5R) is known to decrease ROS production. Activation of autophagy by D5R plays a role in inhibiting mito-ROS production in the kidneys.
HYPERTENSION RESEARCH
(2021)
Article
Environmental Sciences
Shanjie Zha, Yu Tang, Wei Shi, Hongxing Liu, Changsen Sun, Yongbo Bao, Guangxu Liu
Summary: The exposure of blood clams to commonly-used nanoparticles resulted in reduced food intake, energy shortage, and significant threat to the health of this species.
Review
Biochemistry & Molecular Biology
Dandan Huang, Guangqin Jing, Shuhua Zhu
Summary: Hydrogen sulfide (H2S), the third gasotransmitter, has positive roles in animals and plants, particularly in regulating mitochondrial bioenergetic functions and oxidative phosphorylation. This article provides a summary of the current knowledge on the characteristics and biosynthesis of H2S, as well as its regulatory effects on the tricarboxylic acid cycle and mitochondrial respiratory chain.
Article
Cell Biology
Sylwia M. Kacprzak, Olivier Van Aken
Summary: This study reveals that carbon starvation induced by dark-incubation, natural senescence, and specific mitochondrial stresses are key triggers of mitophagy in plants.
Article
Endocrinology & Metabolism
Sarah E. Ehrlicher, Harrison D. Stierwalt, Sean A. Newsom, Matthew M. Robinson
Summary: The study found that a high-fat diet stimulates upstream activation of skeletal muscle mitophagy without altering mitochondrial respiration. This suggests that lipid-induced oxidative stress may be involved in this process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.