Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors

(2018) Alireza Azimi et al.   Molecular Systems Biology

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

(2018) Wang Lai Hu et al.   NATURE CELL BIOLOGY

Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1

(2018) Wei Hang et al.   ONCOGENE

CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer

(2018) Jie Xie et al.   Theranostics

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP

(2016) Min Lu et al.   CANCER CELL

Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools

(2016) A Bianchi-Smiraglia et al.   ONCOGENE

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

(2016) Jessica S. Brown et al.   Cancer Discovery

BRAF V600E Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

(2016) Kristel Kemper et al.   Cell Reports

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

(2015) Lei Wang et al.   CANCER CELL

Phytochemical and Pharmacological Profile ofVitex negundo

(2015) Cheng-Jian Zheng et al.   PHYTOTHERAPY RESEARCH

Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death

(2015) Joungyoun Noh et al.   Nature Communications

The p53 control of apoptosis and proliferation: lessons from Drosophila

(2014) Bertrand Mollereau et al.   APOPTOSIS

Recent developments in the medical and surgical treatment of melanoma

(2014) Vita Saranga-Perry et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

LKB1 reduces ROS-mediated cell damage via activation of p38

(2014) H-G Xu et al.   ONCOGENE

The melanoma revolution: From UV carcinogenesis to a new era in therapeutics

(2014) J. A. Lo et al.   SCIENCE

The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models

(2014) D J Colin et al.   Cell Death & Disease

The p53 protein and its molecular network: Modelling a missing link between DNA damage and cell fate

(2013) Ján Eliaš et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Melanoma epidemiology, biology and prognosis

(2013) Z. Ali et al.   EJC SUPPLEMENTS

Hepatoprotective Role of Ethanolic Extract ofVitex negundoin Thioacetamide-Induced Liver Fibrosis in Male Rats

(2013) Farkaad A. Kadir et al.   Evidence-based Complementary and Alternative Medicine

Anti-inflammatory and anti-osteoporotic lignans from Vitex negundo seeds

(2013) Cheng-Jian Zheng et al.   FITOTERAPIA

Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular carcinoma

(2013) JIANGANG WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction

(2013) Hong Xin et al.   PHYTOMEDICINE

In vitro and in vivo bactericidal activity of Vitex negundo leaf extract against diverse multidrug resistant enteric bacterial pathogens

(2013) Muhammad Kamruzzaman et al.   Asian Pacific Journal of Tropical Medicine

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

(2013) N. Wagle et al.   Cancer Discovery

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

Purified Vitexin Compound 1 Suppresses Tumor Growth and Induces Cell Apoptosis in a Mouse Model of Human Choriocarcinoma

(2012) Zhihui Tan et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

NRAS mutant melanoma: biological behavior and future strategies for therapeutic management

(2012) I V Fedorenko et al.   ONCOGENE

Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

(2012) Maria R. Girotti et al.   Cancer Discovery

Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells

(2011) T. Mazumdar et al.   CANCER RESEARCH

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Vitexins, Nature-Derived Lignan Compounds, Induce Apoptosis and Suppress Tumor Growth

(2009) Y. Zhou et al.   CLINICAL CANCER RESEARCH