Sublethal heat stress-induced O-GlcNAcylation coordinates the Warburg effect to promote hepatocellular carcinoma recurrence and metastasis after thermal ablation

Applications of patient-derived tumor xenograft models and tumor organoids

(2020) Go J. Yoshida   Journal of Hematology & Oncology

Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia

(2020) Anwen Shao et al.   ONCOGENE

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

(2020) Hao Nie et al.   Nature Communications

O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia

(2020) Yinrui Lei et al.   Oncogenesis

Power of two: Combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer

(2020) Kalpana Tilekar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance

(2019) Xing Huang et al.   Autophagy

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

(2019) Neha M. Akella et al.   BMC BIOLOGY

FRK plays an oncogenic role in non‐small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming

(2019) Li Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Sublethal heat treatment of hepatocellular carcinoma promotes intrahepatic metastasis and stemness in a VEGFR1-dependent manner

(2019) Li Tan et al.   CANCER LETTERS

Chemoembolization Combined with Radiofrequency Ablation for Medium-Sized Hepatocellular Carcinoma: A Propensity-Score Analysis

(2019) Hee Ho Chu et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

(2019) Liangrong Shi et al.   Nature Communications

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

(2019) Ali F. Abdel-Wahab et al.   PHARMACOLOGICAL RESEARCH

Insufficient radiofrequency ablation promotes proliferation of residual hepatocellular carcinoma via autophagy

(2018) Zizhuo Zhao et al.   CANCER LETTERS

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

Monocyte chemoattractant protein-induced protein 1 targets hypoxia-inducible factor 1α to protect against hepatic ischemia/reperfusion injury

(2018) Peng Sun et al.   HEPATOLOGY

O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle

(2018) John A. Hanover et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Stress-induced phosphoprotein 1 mediates hepatocellular carcinoma metastasis after insufficient radiofrequency ablation

(2018) Tianhong Su et al.   ONCOGENE

Heat Stress and Hepatic Laser Thermal Ablation Induce Hepatocellular Carcinoma Growth: Role of PI3K/mTOR/AKT Signaling

(2018) Danielle E. Jondal et al.   RADIOLOGY

Medium or Large Hepatocellular Carcinoma: Sorafenib Combined with Transarterial Chemoembolization and Radiofrequency Ablation

(2018) Kangshun Zhu et al.   RADIOLOGY

Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice

(2018) Ruizhi Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress

(2017) Cuifang Han et al.   Nature Communications

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism

(2017) Balaraman Kalyanaraman   Redox Biology

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways

(2016) Jun Wan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Incomplete radiofrequency ablation accelerates proliferation and angiogenesis of residual lung carcinomas via HSP70/HIF-1α

(2016) Jun Wan et al.   ONCOLOGY REPORTS

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

The Warburg effect: Evolving interpretations of an established concept

(2015) Xiaozhuo Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells

(2015) MARIKO SATO et al.   Molecular Medicine Reports

Clinical outcome of medium-sized hepatocellular carcinoma treated with microwave ablation

(2015) Ai-Xue Sun   WORLD JOURNAL OF GASTROENTEROLOGY

Expressions of Hypoxia-Inducible Factor-1 and Epithelial Cell Adhesion Molecule are Linked with Aggressive Local Recurrence of Hepatocellular Carcinoma After Radiofrequency Ablation Therapy

(2014) Shinichiro Yamada et al.   ANNALS OF SURGICAL ONCOLOGY

Local tumour progression after ultrasound-guided microwave ablation of liver malignancies: risk factors analysis of 2529 tumours

(2014) Jie Yu et al.   EUROPEAN RADIOLOGY

Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis

(2013) Jennifer A. Groves et al.   CELL STRESS & CHAPERONES

Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma

(2013) Shuhei Yoshida et al.   HEPATOLOGY

Tissue metabolomics of hepatocellular carcinoma: Tumor energy metabolism and the role of transcriptomic classification

(2013) Diren Beyoğlu et al.   HEPATOLOGY

Percutaneous ablation therapy versus surgical resection in the treatment for early-stage hepatocellular carcinoma: a meta-analysis of 21,494 patients

(2013) Jia-yan Ni et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Value of18F-FDG-PET/CT in the detection of recurrent hepatocellular carcinoma after hepatectomy or radiofrequency ablation: A comparative study with contrast-enhanced ultrasound

(2013) Xiao Yan Wang et al.   Journal of Digestive Diseases

The metabolomic window into hepatobiliary disease

(2013) Diren Beyoğlu et al.   JOURNAL OF HEPATOLOGY

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Radiofrequency Ablation of Hepatocellular Carcinoma as First-Line Treatment: Long-term Results and Prognostic Factors in 162 Patients with Cirrhosis

(2013) Dong Ho Lee et al.   RADIOLOGY

Medium-Sized (3.1–5.0 cm) Hepatocellular Carcinoma: Transarterial Chemoembolization Plus Radiofrequency Ablation Versus Radiofrequency Ablation Alone

(2011) Jin Hyoung Kim et al.   ANNALS OF SURGICAL ONCOLOGY

Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells

(2011) D Trisciuoglio et al.   CELL DEATH AND DIFFERENTIATION

Highly sensitive AFP-L3% assay is useful for predicting recurrence of hepatocellular carcinoma after curative treatment pre- and postoperatively

(2011) Masahiro Kobayashi et al.   HEPATOLOGY RESEARCH

Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis

(2011) Koji Kitamura et al.   JOURNAL OF HEPATOLOGY

STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect

(2009) Sean P Pitroda et al.   BMC Medicine