O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

(2018) Fu-Long Li et al.   Nature Communications

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

(2018) Nina M. S. Gustafsson et al.   Nature Communications

O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency

(2017) Ting Wang et al.   NATURE CELL BIOLOGY

High glucose levels boost the aggressiveness of highly metastatic cholangiocarcinoma cells via O-GlcNAcylation

(2017) Chatchai Phoomak et al.   Scientific Reports

Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms

(2016) Stefan Burén et al.   CANCER CELL

Nutrient regulation of gene expression by O-GlcNAcylation of chromatin

(2016) Stéphan Hardivillé et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

(2016) Christina M. Ferrer et al.   JOURNAL OF MOLECULAR BIOLOGY

Hypoxia inhibits mesenchymal stem cell proliferation through HIF1α-dependent regulation of P27

(2016) Sanjay Kumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription

(2016) Aristeidis E. Boukouris et al.   TRENDS IN BIOCHEMICAL SCIENCES

O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes

(2016) Steffi F. Baldini et al.   Frontiers in Oncology

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth

(2015) Xiongjian Rao et al.   Nature Communications

O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity

(2014) Alexis K. Nagel et al.   AMINO ACIDS

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

(2014) Oleksandr H Minchenko   WORLD JOURNAL OF GASTROENTEROLOGY

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

(2014) A Yalcin et al.   Cell Death & Disease

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

(2013) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A metabolic metamorphosis

(2013) Abigail S. Krall et al.   NATURE

The nexus of chromatin regulation and intermediary metabolism

(2013) Philipp Gut et al.   NATURE

Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases

(2009) Abdullah Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Glucose Deprivation StimulatesO-GlcNAc Modification of Proteins through Up-regulation ofO-LinkedN-Acetylglucosaminyltransferase

(2008) Rodrick P. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY