A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics

Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS

(2021) Wouter J. Peyrot et al.   NATURE GENETICS

Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations

(2021) Haojie Lu et al.   HUMAN GENETICS

Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders

(2020) Shahram Bahrami et al.   JAMA Psychiatry

Alcohol Drinking and Amyotrophic Lateral Sclerosis: An Instrumental Variable Causal Inference

(2020) Xinghao Yu et al.   ANNALS OF NEUROLOGY

Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

(2020) Elliott Rees et al.   Genome Medicine

The shared genetic architecture of schizophrenia, bipolar disorder and lifespan

(2020) Gerard Muntané et al.   HUMAN GENETICS

An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices

(2020) Muzamil Majid Khan et al.   EUROPEAN RESPIRATORY JOURNAL

Integration of the Drug–Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts

(2020) Sharon L Freshour et al.   NUCLEIC ACIDS RESEARCH

Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults

(2019) Karmel W. Choi et al.   JAMA Psychiatry

Shared genetic etiology between anxiety disorders and psychiatric and related intermediate phenotypes

(2019) Kazutaka Ohi et al.   PSYCHOLOGICAL MEDICINE

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

(2019) Andrew J. Schork et al.   NATURE NEUROSCIENCE

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Common knowledge: shared genetics in psychiatry

(2019) Lea Karatheodoris Davis   NATURE NEUROSCIENCE

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

(2019) Patrick F. Sullivan et al.   CELL

Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

(2019) Dongmei Yu et al.   AMERICAN JOURNAL OF PSYCHIATRY

Variance component tests of multivariate mediation effects under composite null hypotheses

(2019) Yen‐Tsung Huang   BIOMETRICS

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Genetic correlations of polygenic disease traits: from theory to practice

(2019) Wouter van Rheenen et al.   NATURE REVIEWS GENETICS

Causal Association Between Birth Weight and Adult Diseases: Evidence From a Mendelian Randomization Analysis

(2019) Ping Zeng et al.   Frontiers in Genetics

Discovery of shared genomic loci using the conditional false discovery rate approach

(2019) Olav B. Smeland et al.   HUMAN GENETICS

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges

(2019) Olav B. Smeland et al.   PSYCHIATRIC GENETICS

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

(2019) Caroline M. Nievergelt et al.   Nature Communications

Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics

(2019) Ping Zeng et al.   BMC Medicine

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

(2019) Phil H. Lee et al.   CELL

Assessing the Causal Effects of Human Serum Metabolites on 5 Major Psychiatric Disorders

(2019) Jian Yang et al.   SCHIZOPHRENIA BULLETIN

A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci

(2018) Ganna Leonenko et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Psychiatric Genomics: An Update and an Agenda

(2018) Patrick F. Sullivan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Pleiotropic mapping and annotation selection in genome-wide association studies with penalized Gaussian mixture models

(2018) Ping Zeng et al.   BIOINFORMATICS

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

(2018) Marissa LeBlanc et al.   BMC GENOMICS

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

(2018) Douglas M. Ruderfer et al.   CELL

Global transcriptome profiling of mild relapsing-remitting versus primary progressive multiple sclerosis

(2018) M. W. Koch et al.   EUROPEAN JOURNAL OF NEUROLOGY

Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity

(2018) Dirk J.A. Smit et al.   HUMAN BRAIN MAPPING

Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia inMAPTmutation carriers

(2018) Gayathri Cheran et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Psychiatric genetics and the structure of psychopathology

(2018) Jordan W. Smoller et al.   MOLECULAR PSYCHIATRY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Shared genetic etiology between alcohol dependence and major depressive disorder

(2018) Jerome C. Foo et al.   PSYCHIATRIC GENETICS

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

(2018) Michael J. Gandal et al.   SCIENCE

Examination of the shared genetic basis of anorexia nervosa and obsessive–compulsive disorder

(2018) Zeynep Yilmaz et al.   MOLECULAR PSYCHIATRY

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

(2018) Joëlle A. Pasman et al.   NATURE NEUROSCIENCE

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts

(2018) Sandra Sanchez-Roige et al.   AMERICAN JOURNAL OF PSYCHIATRY

Causal Effects of Blood Lipids on Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study

(2018) Ping Zeng et al.   HUMAN MOLECULAR GENETICS

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Interpreting findings from Mendelian randomization using the MR-Egger method

(2017) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

(2017) Olena O Yavorska et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction

(2017) Susanna C. Larsson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties

(2017) B St Pourcain et al.   MOLECULAR PSYCHIATRY

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

(2017) L E Duncan et al.   MOLECULAR PSYCHIATRY

Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis

(2017) Paul D Arnold et al.   MOLECULAR PSYCHIATRY

Integrating genome-wide association study and expression quantitative trait loci data identifies multiple genes and gene set associated with neuroticism

(2017) Qianrui Fan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not

(2017) M. Aas et al.   PSYCHOLOGICAL MEDICINE

Assessing the evidence for shared genetic risks across psychiatric disorders and traits

(2017) Joanna Martin et al.   PSYCHOLOGICAL MEDICINE

Embracing polygenicity: a review of methods and tools for psychiatric genetics research

(2017) R. M. Maier et al.   PSYCHOLOGICAL MEDICINE

Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development

(2017) Michel G Nivard et al.   SCHIZOPHRENIA BULLETIN

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

graph-GPA: A graphical model for prioritizing GWAS results and investigating pleiotropic architecture

(2017) Dongjun Chung et al.   PLoS Computational Biology

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study

(2017) Alastair J. Noyce et al.   PLOS MEDICINE

Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study

(2017) Carlos A. Pardo et al.   Molecular Autism

Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development

(2017) Evie Stergiakouli et al.   Molecular Autism

Selective Interaction of Lansoprazole and Astemizole with Tau Polymers: Potential New Clinical Use in Diagnosis of Alzheimer's Disease

(2017) Leonel E. Rojo et al.   JOURNAL OF ALZHEIMERS DISEASE

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

(2016) Liping Hou et al.   HUMAN MOLECULAR GENETICS

A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping

(2016) Buhm Han et al.   HUMAN MOLECULAR GENETICS

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

(2016) Jochen Schmitt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen

(2016) Xing Chen et al.   MOLECULAR NEUROBIOLOGY

Meta-analysis of genome-wide association studies of anxiety disorders

(2016) T Otowa et al.   MOLECULAR PSYCHIATRY

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

The implications of the shared genetics of psychiatric disorders

(2016) Michael C O'Donovan et al.   NATURE MEDICINE

Genetic pleiotropy in complex traits and diseases: implications for genomic medicine

(2016) Jacob Gratten et al.   Genome Medicine

Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia

(2016) J Costas et al.   Translational Psychiatry

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

(2015) Hansjörg Baurecht et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2015) Robert Maier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Research Letter: PTSD has shared polygenic contributions with bipolar disorder and schizophrenia in women

(2015) J. A. Sumner et al.   PSYCHOLOGICAL MEDICINE

A review of instrumental variable estimators for Mendelian randomization

(2015) Stephen Burgess et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease

(2015) Omar S. Ahmad et al.   Nature Communications

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Rare-Variant Association Analysis: Study Designs and Statistical Tests

(2014) Seunggeung Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Likelihood Ratio Tests in Rare Variant Detection for Continuous Phenotypes

(2014) Ping Zeng et al.   ANNALS OF HUMAN GENETICS

Estimating and Testing Pleiotropy of Single Genetic Variant for Two Quantitative Traits

(2014) Qunyuan Zhang et al.   GENETIC EPIDEMIOLOGY

Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia

(2014) Per Ivar Finseth et al.   JOURNAL OF AFFECTIVE DISORDERS

Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism

(2014) Chor Hong Lim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Genetic Relationships Between Schizophrenia, Bipolar Disorder, and Schizoaffective Disorder

(2014) A. G. Cardno et al.   SCHIZOPHRENIA BULLETIN

Genome-wide association study reveals two new risk loci for bipolar disorder

(2014) Thomas W. Mühleisen et al.   Nature Communications

GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation

(2014) Dongjun Chung et al.   PLoS Genetics

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

GEE-Based SNP Set Association Test for Continuous and Discrete Traits in Family-Based Association Studies

(2013) Xuefeng Wang et al.   GENETIC EPIDEMIOLOGY

Kernel Machine SNP-Set Testing Under Multiple Candidate Kernels

(2013) Michael C. Wu et al.   GENETIC EPIDEMIOLOGY

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

(2013) D M Ruderfer et al.   MOLECULAR PSYCHIATRY

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

DGIdb: mining the druggable genome

(2013) Malachi Griffith et al.   NATURE METHODS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

(2013) Ole A. Andreassen et al.   PLoS Genetics

Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies

(2012) Seunggeun Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders

(2011) Dan Levy et al.   NEURON

Powerful SNP-Set Analysis for Case-Control Genome-wide Association Studies

(2010) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

(2010) Nanda N. J. Rommelse et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Meta-Analysis of Genome-wide Association Studies with Overlapping Subjects

(2009) Dan-Yu Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Protective Effect of CRHR1 Gene Variants on the Development of Adult Depression Following Childhood Maltreatment

(2009) Guilherme Polanczyk et al.   ARCHIVES OF GENERAL PSYCHIATRY

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

(2009) Paul Lichtenstein et al.   LANCET

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoimmune diseases: insights from genome-wide association studies

(2008) G. Lettre et al.   HUMAN MOLECULAR GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Mendelian Randomisation and Causal Inference in Observational Epidemiology

(2008) Nuala A Sheehan et al.   PLOS MEDICINE

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE