Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Synthesis and characterization of lysozyme-conjugated Ag.ZnO@HA nanocomposite: A redox and pH-responsive antimicrobial agent with photocatalytic activity

(2021) Hanieh Lotfali et al.   Photodiagnosis and Photodynamic Therapy

N-Acetylcysteine (NAC): Impacts on Human Health

(2021) Micaely Cristina dos Santos Tenório et al.   Antioxidants

Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy

(2021) Junchuan Zhang et al.   CHEMICAL ENGINEERING JOURNAL

Self-Delivered and Self-Monitored Chemo-Photodynamic Nanoparticles with Light-Triggered Synergistic Antitumor Therapies by Downregulation of HIF-1α and Depletion of GSH

(2020) Zhongtao Zhang et al.   ACS Applied Materials & Interfaces

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

(2020) Yanjuan Sang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells

(2020) Yinchao Li et al.   Frontiers in Oncology

Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance

(2020) Adriana Cruz et al.   Antioxidants

Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

(2020) Zhao Wang et al.   ACS Applied Materials & Interfaces

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

(2020) Yunpeng Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Copper-Doped Nanoscale Covalent Organic Polymer for Augmented Photo/Chemodynamic Synergistic Therapy and Immunotherapy

(2020) Chunling Hu et al.   BIOCONJUGATE CHEMISTRY

Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS

(2020) Zeqian Huang et al.   CHEMICAL ENGINEERING JOURNAL

A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy

(2020) Dihai Gu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Lowering glutathione level by buthionine sulfoximine enhances in vivo photodynamic therapy using chlorin e6-loaded nanoparticles

(2020) Jihye Yoo et al.   DYES AND PIGMENTS

Dual Receptor-Targeted and Redox-Sensitive Polymeric Micelles Self-Assembled from a Folic Acid-Hyaluronic Acid-SS-Vitamin E Succinate Polymer for Precise Cancer Therapy

(2020) Yue Yang et al.   International Journal of Nanomedicine

Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy

(2020) Peijing An et al.   JOURNAL OF CONTROLLED RELEASE

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

(2020) Conghui Liu et al.   Nature Communications

The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells

(2020) Magdalena Cal et al.   Cells

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

(2020) Jinchao Shen et al.   BIOMATERIALS

Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery-associated challenges

(2020) Min Zhang et al.   JOURNAL OF CONTROLLED RELEASE

A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition

(2020) Jinhui Hu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

(2020) Haozhe He et al.   Small

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility

(2020) Yixian Zhou et al.   Acta Pharmaceutica Sinica B

Inhibiting Radiative Transition-Mediated Multifunctional Polymeric Nanoplatforms for Highly Efficient Tumor Phototherapeutics

(2020) Yucheng Zhu et al.   ACS Applied Materials & Interfaces

Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy

(2020) Jianzhi Zhu et al.   ACS Nano

Metal–Organic Framework Derived Multicomponent Nanoagent as a Reactive Oxygen Species Amplifier for Enhanced Photodynamic Therapy

(2020) Dongdong Wang et al.   ACS Nano

A Smart Nanoparticle-Laden and Remote-Controlled Self-Destructive Macrophage for Enhanced Chemo/Chemodynamic Synergistic Therapy

(2020) Panpan Sun et al.   ACS Nano

Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

(2020) Jimei Zhang et al.   ACS Nano

Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging

(2020) Yuanyuan Yang et al.   ACS Nano

Bimetallic Oxide FeWO X Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy

(2020) Fei Gong et al.   ADVANCED FUNCTIONAL MATERIALS

An Ultrasmall SnFe 2 O 4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

(2020) Lili Feng et al.   ADVANCED FUNCTIONAL MATERIALS

Yolk‐Shell Structured Nanoflowers Induced Intracellular Oxidative/Thermal Stress Damage for Cancer Treatment

(2020) Miao‐Deng Liu et al.   ADVANCED FUNCTIONAL MATERIALS

GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

(2020) Shuming Dong et al.   ADVANCED MATERIALS

Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme‐Loaded Electrophilic ZIFs

(2020) Yanli Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy

(2020) Yanli Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy

(2020) Shiyan Fu et al.   BIOMATERIALS

Boosted photocatalytic activity induced NAMPT-Regulating therapy based on elemental bismuth-humic acids heterojunction for inhibiting tumor proliferation/migration/inflammation

(2020) Yilin Song et al.   BIOMATERIALS

Multifunctional FeS2 theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging

(2020) Shuting Xiao et al.   CHEMICAL ENGINEERING JOURNAL

Tumor-specific carrier-free nanodrugs with GSH depletion and enhanced ROS generation for endogenous synergistic anti-tumor by a chemotherapy-photodynamic therapy

(2020) Jin-Shuai Lan et al.   CHEMICAL ENGINEERING JOURNAL

Near Infrared‐Activatable Platinum‐Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance

(2020) Andrea C. Valle et al.   Advanced Healthcare Materials

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer

(2020) Zhanwei Zhou et al.   Science Advances

Small size gold nanoparticles enhance apoptosis-induced by cold atmospheric plasma via depletion of intracellular GSH and modification of oxidative stress

(2020) Paras Jawaid et al.   Cell Death Discovery

Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy

(2020) Yuanyuan Yang et al.   BIOMATERIALS

A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy

(2020) Jian Chen et al.   BIOMATERIALS

A glutathione-activatable nanoplatform for enhanced photodynamic therapy with simultaneous hypoxia relief and glutathione depletion

(2020) Furong Liu et al.   CHEMICAL ENGINEERING JOURNAL

Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy

(2020) Xinyu Shen et al.   Nano Today

Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay

(2019) Marcelo Farina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

Nanomaterial-induced ferroptosis for cancer specific therapy

(2019) Mei Liu et al.   COORDINATION CHEMISTRY REVIEWS

Biomimetic Metal-Organic Framework Nanoparticles for Cooperatively Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy

(2019) Huan Min et al.   ADVANCED MATERIALS

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

(2019) Conghui Liu et al.   ACS Nano

A Mn(III)-Sealed Metal-Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics

(2019) Shuang-Shuang Wan et al.   ACS Nano

Persistent Regulation of Tumor Microenvironment via Circulating Catalysis of MnFe 2 O 4 @Metal–Organic Frameworks for Enhanced Photodynamic Therapy

(2019) Sheng‐Yan Yin et al.   ADVANCED FUNCTIONAL MATERIALS

Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWO X Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy

(2019) Fei Gong et al.   ADVANCED MATERIALS

Specifically Generation of Singlet Oxygen via Russell Mechanism in Hypoxic Tumor and GSH Depletion by Cu-TCPP Nanosheets for Cancer Therapy

(2019) Chao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion

(2019) Gaofei Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Self‐Assemble Polymeric Nanoparticle with GSH Exhaustion for SPECT Imaging–Guided Enhanced Radioisotope Therapy

(2019) Yugui Tao et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Monodispersed Copper(I)‐Based Nano Metal–Organic Framework as a Biodegradable Drug Carrier with Enhanced Photodynamic Therapy Efficacy

(2019) Xuechao Cai et al.   Advanced Science

Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal–Organic Framework

(2019) Yuanbo Wang et al.   ACS Nano

Fe(III)‐Porphyrin Sonotheranostics: A Green Triple‐Regulated ROS Generation Nanoplatform for Enhanced Cancer Imaging and Therapy

(2019) Jing Zhu et al.   ADVANCED FUNCTIONAL MATERIALS

Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy

(2019) Tingting Luo et al.   CARBOHYDRATE POLYMERS

Three birds with one stone: a ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion

(2019) Yanjuan Huang et al.   CHEMICAL ENGINEERING JOURNAL

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Glutathione-mediated biotransformation in the liver modulates nanoparticle transport

(2019) Xingya Jiang et al.   Nature Nanotechnology

Tumor-Specific Expansion of Oxidative Stress by Glutathione Depletion and Use of a Fenton Nanoagent for Enhanced Chemodynamic Therapy

(2019) Qiufang Chen et al.   ACS Applied Materials & Interfaces

O2-Cu/ZIF-8@Ce6/ZIF-8@F127 Composite as a Tumor Microenvironment-Responsive Nanoplatform with Enhanced Photo-/Chemodynamic Antitumor Efficacy

(2019) Zhongxi Xie et al.   ACS Applied Materials & Interfaces

Reactive Oxygen Species–Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies

(2019) Zhihao Zhao et al.   ADVANCED FUNCTIONAL MATERIALS

Non‐Fenton‐Type Hydroxyl Radical Generation and Photothermal Effect by Mitochondria‐Targeted WSSe/MnO 2 Nanocomposite Loaded with Isoniazid for Synergistic Anticancer Treatment

(2019) Yaru Cheng et al.   ADVANCED FUNCTIONAL MATERIALS

Sanguinarine enhances cisplatin sensitivity via glutathione depletion in cisplatin‐resistant ovarian cancer (A2780) cells

(2019) Roya Sarkhosh‐Inanlou et al.   Chemical Biology & Drug Design

Metadherin enhances vulnerability of cancer cells to ferroptosis

(2019) Jianling Bi et al.   Cell Death & Disease

Photothermal-Enhanced Inactivation of Glutathione Peroxidase for Ferroptosis Sensitized by an Autophagy Promotor

(2019) Peijing An et al.   ACS Applied Materials & Interfaces

Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity

(2019) Ying Xu et al.   ACS Nano

GSH‐Depleted PtCu 3 Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy

(2019) Xiaoyan Zhong et al.   ADVANCED FUNCTIONAL MATERIALS

Ultrasound‐Activated Oxygen and ROS Generation Nanosystem Systematically Modulates Tumor Microenvironment and Sensitizes Sonodynamic Therapy for Hypoxic Solid Tumors

(2019) Jingke Fu et al.   ADVANCED FUNCTIONAL MATERIALS

Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy Using a CaCO3 Mineralized Metal-Organic Framework

(2019) Xiuyan Wan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

(2019) Mengyu Yu et al.   CANCER SCIENCE

GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway

(2019) Jingjing Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

(2019) Xuan Meng et al.   NANO LETTERS

Glutathione Depletion in a Benign Manner by MoS 2 ‐Based Nanoflowers for Enhanced Hypoxia‐Irrelevant Free‐Radical‐Based Cancer Therapy

(2019) Si Wu et al.   Small

The Xc− inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism

(2019) Zijie Zheng et al.   CELLULAR ONCOLOGY

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

(2019) Enrico Desideri et al.   Nutrients

The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells

(2019) Matheus Molina Silva et al.   Scientific Reports

Surface Charge Switchable Supramolecular Nanocarriers for Nitric Oxide Synergistic Photodynamic Eradication of Biofilms

(2019) Dengfeng Hu et al.   ACS Nano

Programmed degradation of a hierarchical nanoparticle with redox and light responsivity for self-activated photo-chemical enhanced chemodynamic therapy

(2019) Shenqiang Wang et al.   BIOMATERIALS

Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells

(2019) Hongxia Tang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations

(2018) Xiaodong Zhang et al.   ACS Applied Materials & Interfaces

All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication

(2018) Yang Liu et al.   ACS Nano

Stepwise Degradable Nanocarriers Enabled Cascade Delivery for Synergistic Cancer Therapy

(2018) Yannan Yang et al.   ADVANCED FUNCTIONAL MATERIALS

Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano-MOF with CuII as the Active Center

(2018) Wei Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy

(2018) Xizhen Lian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

(2018) Li-Sen Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug metabolizing enzymes and their inhibitors' role in cancer resistance

(2018) Shelly Pathania et al.   BIOMEDICINE & PHARMACOTHERAPY

Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death

(2018) Wei Zheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT

(2018) Zongqi Wang et al.   CANCER LETTERS

Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects

(2018) Xin Ji et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone

(2018) Xia-Zhen Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle

(2018) Anand Kumar Bachhawat et al.   IUBMB LIFE

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy

(2018) Cheng-Qiong Luo et al.   JOURNAL OF CONTROLLED RELEASE

Intracellular glutathione-depleting polymeric micelles for cisplatin prodrug delivery to overcome cisplatin resistance of cancers

(2018) Yu Han et al.   JOURNAL OF CONTROLLED RELEASE

Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance

(2018) Xiang Ling et al.   NANO LETTERS

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo

(2018) Luigi Mele et al.   Cell Death & Disease

Polyrotaxane-based supramolecular theranostics

(2018) Guocan Yu et al.   Nature Communications

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

(2018) Mami Sato et al.   Scientific Reports

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Nitric oxide as an all-rounder for enhanced photodynamic therapy: Hypoxia relief, glutathione depletion and reactive nitrogen species generation

(2018) Yongyan Deng et al.   BIOMATERIALS

Redox-responsive nano-carriers as tumor-targeted drug delivery systems

(2018) Ali Raza et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glutathione Reductase-mediated Thiol Oxidative Stress Suppresses Metastasis of Murine Melanoma Cells

(2018) Xia Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stimuli-responsive nanoscale drug delivery systems for cancer therapy

(2018) Li Li et al.   JOURNAL OF DRUG TARGETING

Advances in redox-responsive drug delivery systems of tumor microenvironment

(2018) Xiaoshuang Guo et al.   JOURNAL OF NANOBIOTECHNOLOGY

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

(2018) Shuaifei Wang et al.   ACS Nano

Glutathione-Responsive Prodrug Nanoparticles for Effective Drug Delivery and Cancer Therapy

(2018) Xiang Ling et al.   ACS Nano

Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

(2018) Andrea Scirè et al.   BIOFACTORS

Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands

(2018) Xuejiao Li et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux

(2018) Guizhu Wu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Exogenous glutathione improves intracellular glutathione synthesis via the γ-glutamyl cycle in bovine zygotes and cleavage embryos

(2018) Feng Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

(2018) Baojin Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

(2018) Ziliang Dong et al.   NANO LETTERS

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

(2018) Soo Liang Ooi et al.   Biomed Research International

Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity

(2017) Basile Pérès et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

A radical shift in perspective: mitochondria as regulators of reactive oxygen species

(2017) Daniel Munro et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells

(2017) Luiz Felipe de Souza et al.   TOXICOLOGY IN VITRO

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine

(2017) Ioannis Poursaitidis et al.   Cell Reports

Identification of capsazepine as a novel inhibitor of system xc− and cancer-induced bone pain

(2017) Jennifer Fazzari et al.   Journal of Pain Research

Copper(II)-Graphitic Carbon Nitride Triggered Synergy: Improved ROS Generation and Reduced Glutathione Levels for Enhanced Photodynamic Therapy

(2016) Enguo Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells

(2016) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

(2016) Jamie I. Fletcher et al.   DRUG RESISTANCE UPDATES

Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance

(2015) Hsiang-yu Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

(2015) Marie-Helene Larraufie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

(2015) Ming-zhe Ma et al.   CANCER LETTERS

MRP1 and its role in anticancer drug resistance

(2015) Jamie F. Lu et al.   DRUG METABOLISM REVIEWS

Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A-mediatedortho-benzoquinone metabolite formation and glutathione depletion

(2015) Fuguo Shi et al.   JOURNAL OF APPLIED TOXICOLOGY

3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system

(2015) Daniela Valenti et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells

(2015) Ewa Kwiatkowska et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine

(2015) QIWEI LI et al.   Oncology Letters

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

(2015) Daniela Catanzaro et al.   Oncotarget

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

(2014) Doriane Lorendeau et al.   BIOCHEMICAL PHARMACOLOGY

Functional Nanomaterials for Phototherapies of Cancer

(2014) Liang Cheng et al.   CHEMICAL REVIEWS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular targets of isothiocyanates in cancer: Recent advances

(2014) Parul Gupta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Purine Nucleoside Analog - Sulfinosine Modulates Diverse Mechanisms of Cancer Progression in Multi-Drug Resistant Cancer Cell Lines

(2013) Mirjana Dačević et al.   PLoS One

Terminology of metal–organic frameworks and coordination polymers (IUPAC Recommendations 2013)

(2013) Stuart R. Batten et al.   PURE AND APPLIED CHEMISTRY

Oxidative stress contributes to gold nanoparticle-induced cytotoxicity in human tumor cells

(2013) Diego Mateo et al.   TOXICOLOGY MECHANISMS AND METHODS

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione levels in human tumors

(2012) Michael P. Gamcsik et al.   BIOMARKERS

Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma

(2012) C. W. Barrett et al.   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells

(2012) FENG-HOU GAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

(2011) C. J. Henderson et al.   CANCER RESEARCH

Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of  -Lapachone for Pancreatic Cancer Therapy

(2011) L. S. Li et al.   CLINICAL CANCER RESEARCH

Association of Glutathione Level and Cytotoxicity of Gold Nanoparticles in Lung Cancer Cells

(2011) Yunxue Zhao et al.   Journal of Physical Chemistry C

Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: The role of glutathione

(2011) Heather M. Brechbuhl et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines

(2011) Sanchali Gupta Mukherjee et al.   TOXICOLOGY IN VITRO

Thiol-Ene Click Chemistry

(2010) Charles E. Hoyle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1

(2010) Régis Barattin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Thiol Reactivity and Its Impact on the Ciliate Toxicity of α,β-Unsaturated Aldehydes, Ketones, and Esters

(2010) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Reactive oxygen species and endothelial function in diabetes

(2010) Zahra Fatehi-Hassanabad et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress

(2010) Cecile M. Krejsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncologic photodynamic therapy photosensitizers: A clinical review

(2010) Ron R. Allison et al.   Photodiagnosis and Photodynamic Therapy

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

(2010) Mei Jing Piao et al.   TOXICOLOGY LETTERS

Redox Regulation of γ-Glutamyl Transpeptidase

(2009) Hongqiao Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation

(2009) Yong Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi

(2009) K. J. Ritchie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells

(2008) Magdalena L. Circu et al.   BIOCHEMICAL PHARMACOLOGY

Glutathione Depletion and Disruption of Intracellular Ionic Homeostasis Regulate Lymphoid Cell Apoptosis

(2008) Rodrigo Franco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants

(2008) Lorien J. Parker et al.   JOURNAL OF MOLECULAR BIOLOGY

Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

(2008) C. Carlson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

(2008) Nazzareno Ballatori et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Cellular responses induced by silver nanoparticles: In vitro studies

(2008) S. Arora et al.   TOXICOLOGY LETTERS

Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2

(2007) Dianne M. Walters et al.   ANTIOXIDANTS & REDOX SIGNALING