Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells

Employing multi-omics to elucidate the hormetic response against oxidative stress exerted by nC60 on Daphnia pulex

(2019) Pu Wang et al.   ENVIRONMENTAL POLLUTION

Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell CarcinomaIn Vitroand Patient-Derived XenograftsIn Vivo

(2018) Mengqiu Song et al.   MOLECULAR CANCER THERAPEUTICS

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

(2018) Qiang Zhang et al.   Cell Death & Disease

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

(2018) Naoise C. Synnott et al.   Translational Oncology

The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells

(2018) Michele Vasaturo et al.   Scientific Reports

Gene expression profiling and pathway network analysis of anti-tumor activity by Jaridon 6 in esophageal cancer

(2017) Ling Fu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recuperating Lung Decoction Attenuates the Oxidative Stress State of Chronic Obstructive Pulmonary Disease by Inhibiting the MAPK/AP-1 Signal Pathway and Regulating γ-GCS

(2017) Chunlei Li et al.   Evidence-based Complementary and Alternative Medicine

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation

(2017) Xiaoning Liu et al.   Oncology Letters

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

(2017) David S. Liu et al.   Nature Communications

Oridonin Inhibits Cell Proliferation and Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

(2016) Cai-hong Shang et al.   INFLAMMATION

The tumor microenvironment in esophageal cancer

(2016) E W Lin et al.   ONCOGENE

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

(2015) N Mohell et al.   Cell Death & Disease

The Antitumor Activity of the Novel Compound Jesridonin on Human Esophageal Carcinoma Cells

(2015) Cong Wang et al.   PLoS One

Overexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis

(2015) Ni Shi et al.   Oncotarget

PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance

(2014) B. Tessoulin et al.   BLOOD

Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

(2014) Liang-Mou Kuo et al.   MOLECULES

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells

(2013) Tao Zhang et al.   Wspolczesna Onkologia-Contemporary Oncology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis

(2012) LIFANG WANG et al.   Oncology Letters