The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells

ROS-induced oxidative damage in lymphocytes ex vivo/in vitro from healthy individuals and MGUS patients: protection by myricetin bulk and nanoforms

(2020) Shabana Akhtar et al.   ARCHIVES OF TOXICOLOGY

DNA Strand Break Properties of Protoporphyrin IX by X-ray Irradiation against Melanoma

(2020) Takema Hasegawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment

(2019) Tengjiao Fan et al.   Cancers

Crucial role of the pentose phosphate pathway in malignant tumors (Review)

(2019) Lin Jin et al.   Oncology Letters

Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection

(2019) Chaoyou Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electron‐Induced Reactions in 3‐Bromopyruvic Acid

(2019) Filipe Ferreira da Silva et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin

(2019) Yogesh Rai et al.   BIOSCIENCE REPORTS

DNA damage kinase signaling: checkpoint and repair at 30 years

(2019) Michael Charles Lanz et al.   EMBO JOURNAL

DNA Oxidation and Excision Repair Pathways

(2019) Tae-Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis

(2018) Tomasz Jagielski et al.   Frontiers in Pharmacology

Error‐free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin

(2018) Ireneusz Litwin et al.   EMBO JOURNAL

The antimetabolite 3-bromopyruvate selectively inhibits Staphylococcus aureus

(2018) Paolo Visca et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

(2018) Young H. Ko et al.   YEAST

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

(2017) Weibin Wang et al.   GENES & DEVELOPMENT

The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view

(2017) Salah Mohamed El Sayed et al.   MEDICAL HYPOTHESES

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

(2016) Laszlo Tretter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

(2016) J. Azevedo-Silva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

(2016) Paweł Lis et al.   MOLECULES

Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione

(2016) Izabela Sadowska-Bartosz et al.   Pharmacological Reports

Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma

(2016) Katarzyna Niedźwiecka et al.   Oncotarget

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

(2016) Vyom Sharma et al.   Oncotarget

Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer

(2015) Yiming Sun et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

(2015) Rebecca Kohnken et al.   Molecular Cancer

Killing multiple myeloma cells with the small molecule 3-bromopyruvate

(2014) Grażyna Majkowska-Skrobek et al.   ANTI-CANCER DRUGS

The energy blockers 3-bromopyruvate and lonidamine: effects on bioenergetics of brain mitochondria

(2014) Lara Macchioni et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

3-Bromopyruvate: A novel antifungal agent against the human pathogen Cryptococcus neoformans

(2013) Mariusz Dyląg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of 3-bromopyruvic acid on human erythrocyte antioxidant defense system

(2013) Izabela Sadowska-Bartosz et al.   CELL BIOLOGY INTERNATIONAL

Oxidative Stress and Replication-Independent DNA Breakage Induced by Arsenic in Saccharomyces cerevisiae

(2013) Ireneusz Litwin et al.   PLoS Genetics

Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate

(2012) Odília Queirós et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

(2012) Y. H. Ko et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae

(2012) Paweł Lis et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside: introduction to a special issue

(2012) Peter L. Pedersen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

(2012) Kivanç Birsoy et al.   NATURE GENETICS

D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate

(2011) S M El Sayed et al.   CANCER GENE THERAPY

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

The Swi2–Snf2-like protein Uls1 is involved in replication stress response

(2011) Magdalena Cal-Bąkowska et al.   NUCLEIC ACIDS RESEARCH

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Choreography of recombination proteins during the DNA damage response

(2009) Michael Lisby et al.   DNA REPAIR

Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells

(2008) Ji Su Kim et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

(2008) Linda Strandberg Ihrlund et al.   Molecular Oncology

Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage

(2008) Jingyang Chen et al.   NUCLEIC ACIDS RESEARCH

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY