Amyloid Beta-Peptide 25–35 (Aβ25–35) Induces Cytotoxicity via Multiple Mechanisms: Roles of the Inhibition of Glucosylceramide Synthase by Aβ25–35 and Its Protection by D609

Novel signaling aspects of ceramide 1-phosphate

(2020) Natalia Presa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Exploring Sphingolipid Implications in Neurodegeneration

(2020) Alice V. Alessenko et al.   Frontiers in Neurology

Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis

(2020) Mayuko Hori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide

(2020) Takuya Honda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

(2019) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Amyloid β oligomers inhibit growth of human cancer cells

(2019) Bozena Pavliukeviciene et al.   PLoS One

Do Cholesterol and Sphingomyelin Change the Mechanism of Aβ25–35 Peptide Binding to Zwitterionic Bilayer?

(2019) Amy K. Smith et al.   Journal of Chemical Information and Modeling

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells

(2018) Marthe-Susanna Wegner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Asiatic acid protects differentiated PC12 cells from Aβ 25–35 -induced apoptosis and tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β signaling

(2018) Wenjing Cheng et al.   LIFE SCIENCES

Glutathione-mimetic D609 alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model

(2018) Hui Yang et al.   NEUROREPORT

Effect of amyloid beta on ATP-binding cassette transporter expression and activity in porcine brain microvascular endothelial cells

(2018) Maryam H. Shubbar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme

(2016) Naohiro Hashimoto et al.   NEUROPHARMACOLOGY

Mechanism of soluble beta-amyloid 25–35 neurotoxicity in primary cultured rat cortical neurons

(2016) Yong Wang et al.   NEUROSCIENCE LETTERS

Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

(2015) Xian-Le Bu et al.   NEUROTOXICITY RESEARCH

Interaction of Alzheimer’s β-Amyloid Peptides with Cholesterol: Mechanistic Insights into Amyloid Pore Formation

(2014) Coralie Di Scala et al.   BIOCHEMISTRY

Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway

(2014) Md. Golam Sharoar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death

(2014) Oleksandr Pastukhov et al.   BRITISH JOURNAL OF PHARMACOLOGY

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

(2014) James A. Shayman et al.   JOURNAL OF LIPID RESEARCH

Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons

(2014) Wei Shen et al.   JOURNAL OF NEUROCHEMISTRY

Establishment of HeLa Cell Mutants Deficient in Sphingolipid-Related Genes Using TALENs

(2014) Toshiyuki Yamaji et al.   PLoS One

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

β-Glucosidase 2 (GBA2) Activity and Imino Sugar Pharmacology

(2013) Christina M. Ridley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann–Pick C mice

(2012) Jennifer B. Nietupski et al.   MOLECULAR GENETICS AND METABOLISM

Tricyclodecan-9-yl-Xanthogenate (D609) Mechanism of Actions: A Mini-Review of Literature

(2011) Rao Muralikrishna Adibhatla et al.   NEUROCHEMICAL RESEARCH

ABCB1 Protects Kidney Proximal Tubule Cells Against Cadmium-Induced Apoptosis: Roles of Cadmium and Ceramide Transport

(2011) Wing-Kee Lee et al.   TOXICOLOGICAL SCIENCES

Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway

(2010) Eiko Tada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

β-Amyloid peptides 1–40βA and 25–35βA suppress human amylin-mediated death of RINm5F islet β-cells with distinct actions on fibril formation

(2008) Ji-Zhong Bai   CELL BIOLOGY INTERNATIONAL

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: Consequences to morphology and viability on enzyme suppression in cultured primary neurons

(2007) Neville Marks et al.   BRAIN RESEARCH