Shaping mycolactone for therapeutic use against inflammatory disorders

Pleiotropic molecular effects of theMycobacterium ulceransvirulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

(2014) Belinda Hall et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

The Angiotensin II Type 2 Receptor for Pain Control

(2014) A.H. Jan Danser et al.   CELL

Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens

(2014) Laure Guenin-Macé et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synthetic Variants of Mycolactone Bind and Activate Wiskott–Aldrich Syndrome Proteins

(2014) Anne-Caroline Chany et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

(2014) Richard O. Phillips et al.   PLoS Neglected Tropical Diseases

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

(2013) Laure Guenin-Macé et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of TLC-Ag dressings on skin inflammation

(2013) Jean-François Bisson et al.   JOURNAL OF DERMATOLOGY

History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)

(2013) Anne-Caroline Chany et al.   NATURAL PRODUCT REPORTS

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans

(2013) Nicole Scherr et al.   PLoS Neglected Tropical Diseases

A Diverted Total Synthesis of Mycolactone Analogues: An Insight into Buruli Ulcer Toxins

(2011) Anne-Caroline Chany et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Ring-Closing Metathesis (RCM)-Based Approach to Mycolactones A/B

(2011) Philipp Gersbach et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

(2011) L. Guenin-Mace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemistry of mycolactones, the causative toxins of Buruli ulcer

(2011) Y. Kishi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease Monitoring

(2011) Fred S. Sarfo et al.   PLoS Neglected Tropical Diseases

Highly sensitive, operationally simple, cost/time effective detection of the mycolactones from the human pathogen Mycobacterium ulcerans

(2010) Thomas Spangenberg et al.   CHEMICAL COMMUNICATIONS

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

(2009) S. Boulkroun et al.   JOURNAL OF IMMUNOLOGY

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

(2009) R. E. Simmonds et al.   JOURNAL OF IMMUNOLOGY

Immunosuppressive Signature of CutaneousMycobacterium ulceransInfection in the Peripheral Blood of Patients with Buruli Ulcer Disease

(2009) Richard Phillips et al.   JOURNAL OF INFECTIOUS DISEASES

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

(2009) Caroline Demangel et al.   NATURE REVIEWS MICROBIOLOGY

Lipids of Pathogenic Mycobacteria: Contributions to Virulence and Host Immune Suppression

(2009) L. Guenin-Macé et al.   Transboundary and Emerging Diseases

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

(2008) Hui Hong et al.   PLoS Neglected Tropical Diseases