Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

(2021) Michael Thomas et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases

(2021) Violeta Kourbeli et al.   MOLECULES

Bortezomib – First Therapeutic Proteasome Inhibitor for Cancer Therapy: A Review of Patent Literature

(2020) Pratik Ashwinbhai Vora et al.   Recent Patents on Anti-Cancer Drug Discovery

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

(2020) Advait Nagle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

(2019) Susan Wyllie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel Trypanosoma cruzi proteasome inhibitors using a luminescence-based high-throughput screening assay.

(2019) Filip Zmuda et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Protozoan persister-like cells and drug treatment failure

(2019) Michael P. Barrett et al.   NATURE REVIEWS MICROBIOLOGY

Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial

(2018) Faustino Torrico et al.   LANCET INFECTIOUS DISEASES

Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes

(2018) Eva Rico et al.   Scientific Reports

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery

(2018) Lorna M. MacLean et al.   PLoS Neglected Tropical Diseases

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

(2018) Fernando J Sánchez-Valdéz et al.   eLife

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

(2018) Susan Wyllie et al.   NATURE

Clinical and pharmacological profile of benznidazole for treatment of Chagas disease

(2018) Jadel Müller Kratz et al.   Expert Review of Clinical Pharmacology

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

(2018) Victoriano Corpas-Lopez et al.   ACS Infectious Diseases

Identification of Specific Inhibitors of Trypanosoma cruzi Malic Enzyme Isoforms by Target-Based HTS

(2017) Americo T. Ranzani et al.   SLAS Discovery

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

(2016) Shilpi Khare et al.   NATURE

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

(2016) Susan Wyllie et al.   PLoS Pathogens

Toxic Profile of Benznidazole in Patients with Chronic Chagas Disease: Risk Factors and Comparison of the Product from Two Different Manufacturers

(2015) I. Molina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

Biochemical and genetic characterization ofTrypanosoma cruzi N-myristoyltransferase

(2014) Adam J. Roberts et al.   BIOCHEMICAL JOURNAL

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Posaconazole versus Benznidazole for Chronic Chagas' Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Cytosolic NADPH Homeostasis in Glucose-starved ProcyclicTrypanosoma bruceiRelies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux

(2013) Stefan Allmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

(2012) S. Wyllie et al.   Science Translational Medicine

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

(2011) H. Li   BIOINFORMATICS

Antitrypanosomal Therapy for Chronic Chagas' Disease

(2011) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

(2010) Deuan C. Jones et al.   BIOCHEMICAL PHARMACOLOGY

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Characterization of an ABCG-Like Transporter from the Protozoan Parasite Leishmania with a Role in Drug Resistance and Transbilayer Lipid Movement

(2008) E. Castanys-Munoz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel ATP-binding cassette transporter, ABCG6 is involved in chemoresistance of Leishmania

(2007) Somdeb BoseDasgupta et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY