Identification of Specific Inhibitors of Trypanosoma cruzi Malic Enzyme Isoforms by Target-Based HTS

Current drug therapy and pharmaceutical challenges for Chagas disease

(2016) José Bermudez et al.   ACTA TROPICA

Chagas’ Disease

(2015) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis

(2015) Ting Li et al.   Infectious Diseases of Poverty

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytosolic NADPH Homeostasis in Glucose-starved ProcyclicTrypanosoma bruceiRelies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux

(2013) Stefan Allmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety of benznidazole use in the treatment of chronic Chagas' disease

(2012) A. M. Hasslocher-Moreno et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vivosusceptibility to benznidazole ofTrypanosoma cruzistrains from the western Brazilian Amazon

(2012) Ana P. M. Teston et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas Disease

(2011) Lisvane Silva Paes et al.   CURRENT PHARMACEUTICAL DESIGN

Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi

(2011) Alejandro E. Leroux et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs

(2010) C. Bot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative studies on the biochemical properties of  the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei

(2010) Alejandro E. Leroux et al.   FEMS MICROBIOLOGY LETTERS

Chagas disease

(2010) Anis Rassi et al.   LANCET

Long-range interaction between the enzyme active site and a distant allosteric site in the human mitochondrial NAD(P)+-dependent malic enzyme

(2009) Ju-Yi Hsieh et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Surprising variety in energy metabolism within Trypanosomatidae

(2009) Aloysius G.M. Tielens et al.   TRENDS IN PARASITOLOGY

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

(2008) R. Luise Krauth-Siegel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure–activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase

(2008) Jialin Mao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of BRAF Inhibitors through In Silico Screening

(2008) Cheng Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

(2008) A. Cavazzuti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA