Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

(2016) Stephen Patterson et al.   eLife

Nitroheterocyclic drug resistance mechanisms inTrypanosoma brucei

(2015) Susan Wyllie et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New developments in ‘ene’-reductase catalysed biological hydrogenations

(2014) Helen S Toogood et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis

(2014) Rao Mukkavilli et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

High-Confidence Glycosome Proteome for Procyclic Form Trypanosoma brucei by Epitope-Tag Organelle Enrichment and SILAC Proteomics

(2014) Maria Lucia S. Güther et al.   JOURNAL OF PROTEOME RESEARCH

TheREnantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

(2013) Stephen Patterson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

(2012) S. Wyllie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

(2012) Susan E. Cellitti et al.   STRUCTURE

Fexinidazole: A Potential New Drug Candidate for Chagas Disease

(2012) Maria Terezinha Bahia et al.   PLoS Neglected Tropical Diseases

Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

(2011) Belinda S. Hall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

(2011) Meera Gurumurthy et al.   FEBS Journal

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

(2011) T. Downing et al.   GENOME RESEARCH

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

(2011) Belinda S. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of 2H- and 14C-labeled fexinidazole and its primary metabolites labeled with 2H

(2011) E. Fontana et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

(2010) A. Y. Sokolova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver

(2010) M Dogra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

(2010) Els Torreele et al.   PLoS Neglected Tropical Diseases

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Developments in the treatment of visceral leishmaniasis

(2009) Margriet Leontine den Boer et al.   EXPERT OPINION ON EMERGING DRUGS

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes

(2009) Iwanka Kozarewa et al.   NATURE METHODS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE