Review article: insights into the bile acid‐gut microbiota axis in intestinal failure‐associated liver disease—redefining the treatment approach

New Insights into Intestinal Failure Associated Liver Disease in Children

(2020) Racha T. Khalaf et al.   HEPATOLOGY

Cilofexor, a Nonsteroidal FXR Agonist, in Non‐Cirrhotic Patients with Nonalcoholic Steatohepatitis: A Phase 2 Randomized Controlled Trial

(2020) Keyur Patel et al.   HEPATOLOGY

A comparison of small bowel and fecal microbiota in children with short bowel syndrome

(2020) Hannah G. Piper et al.   JOURNAL OF PEDIATRIC SURGERY

Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice

(2020) Jenna Elizabeth Hunt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis

(2020) Kris V. Kowdley et al.   JOURNAL OF HEPATOLOGY

Broad-spectrum antibiotics alter the microbiome, increase intestinal fxr, and decrease hepatic steatosis in zebrafish short bowel syndrome

(2020) Kathryn M. Maselli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis

(2020) Stephen A. Harrison et al.   GASTROENTEROLOGY

Milk Fat Globule Membrane Enhances Colonic–Mucus‐Barrier Function in a Rat Model of Short‐Bowel Syndrome

(2020) Zhicai Yu et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

The Impact of Lactobacillus Probiotics on the Gut Microbiota in Children With Short Bowel Syndrome

(2020) Hannah G. Piper et al.   JOURNAL OF SURGICAL RESEARCH

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

(2020) Masanori Funabashi et al.   NATURE

Prediction, identification and progression of histopathological liver disease activity in children with intestinal failure

(2020) Annika Mutanen et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors

(2020) Sven Francque et al.   Nature Reviews Gastroenterology & Hepatology

NGM 282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients with Nonalcoholic Steatohepatitis

(2019) Stephen A. Harrison et al.   HEPATOLOGY

FXR agonist GW4064 improves the liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection

(2019) Yi Cao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Differential Action of TGR5 Agonists on GLP-2 Secretion and Promotion of Intestinal Adaptation in Piglet Short Bowel Model

(2019) Sen Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study

(2019) Thomas Mouillot et al.   CLINICAL NUTRITION

Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment

(2019) Eva Budinska et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Review article: diagnosis and management of intestinal failure-associated liver disease in adults

(2019) Ashley Bond et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The bacterial communities of the small intestine and stool in children with short bowel syndrome

(2019) Steven L. Zeichner et al.   PLoS One

Probiotic LGG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice

(2019) Yunhuan Liu et al.   HEPATOLOGY

Partially Hydrolyzed Guar Gum Alleviates Small Intestinal Mucosal Damage after Massive Small Bowel Resection along with Changes in the Intestinal Microbiota

(2019) Takayuki Fujii et al.   JOURNAL OF PEDIATRIC SURGERY

Microbial alteration of small bowel stoma effluents and colonic feces in infants with short bowel syndrome

(2019) Tian Zhang et al.   JOURNAL OF PEDIATRIC SURGERY

The Role of Probiotics in Nonalcoholic Fatty Liver Disease: A New Insight into Therapeutic Strategies

(2019) Marica Meroni et al.   Nutrients

Understanding short bowel syndrome: Current status and future perspectives

(2019) Sara Massironi et al.   DIGESTIVE AND LIVER DISEASE

Translation of Evidence Into Practice With Teduglutide in the Management of Adults With Intestinal Failure due to Short‐Bowel Syndrome: A Review of Recent Literature

(2019) Loris Pironi   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Liver Inflammation Relates to Decreased Canalicular Bile Transporter Expression in Pediatric Onset Intestinal Failure

(2018) Annika Mutanen et al.   ANNALS OF SURGERY

Clinical approach to the management of Intestinal Failure Associated Liver Disease (IFALD) in adults: A position paper from the Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN

(2018) Simon Lal et al.   CLINICAL NUTRITION

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

(2018) Phillipp Hartmann et al.   HEPATOLOGY

No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition-Associated Liver Injury in a Novel Extensive Short Bowel Animal Model

(2018) Gustavo Villalona et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Soluble Mediators From Lactobacillus rhamnosus Gorbach-Goldin Support Intestinal Barrier Function in Rats After Massive Small-Bowel Resection

(2018) Jiang Wu et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2018) Stephen A Harrison et al.   LANCET

A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

(2018) Christophe Corpechot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

(2018) Karim C. El Kasmi et al.   Nature Communications

Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

(2018) S.R. Sharpton et al.   Clinical Gastroenterology and Hepatology

The Gut Microbiome in Patients with Intestinal Failure: Current Evidence and Implications for Clinical Practice

(2018) Esther Neelis et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Intestinal Microbiota in Short Bowel Syndrome

(2018) Hannah G. Piper   Seminars in Pediatric Surgery

Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction

(2018) Da Jung Kim et al.   Scientific Reports

Fecal microbiota signatures of adult patients with different types of short bowel syndrome

(2017) Yuhua Huang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15

(2017) Mei Zhou et al.   JOURNAL OF HEPATOLOGY

Toll-like receptor 4 is critical for the development of resection-associated hepatic steatosis

(2017) Lauren K. Barron et al.   JOURNAL OF PEDIATRIC SURGERY

Alterations in intestinal microbiota relate to intestinal failure-associated liver disease and central line infections

(2017) Panliang Wang et al.   JOURNAL OF PEDIATRIC SURGERY

Ursodeoxycholic Acid Suppresses Lipogenesis in Mouse Liver: Possible Role of the Decrease in β-Muricholic Acid, a Farnesoid X Receptor Antagonist

(2017) Kyosuke Fujita et al.   LIPIDS

Mechanisms of bile acid mediated inflammation in the liver

(2017) Man Li et al.   MOLECULAR ASPECTS OF MEDICINE

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Pediatric Intestinal Failure

(2017) Christopher P. Duggan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Differentiation of Intestinal-Failure-Associated Liver Disease from Nonalcoholic Fatty Liver and Nonalcoholic Steatohepatitis

(2017) Bita Naini et al.   SEMINARS IN LIVER DISEASE

Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection

(2017) Yuka Matsumoto et al.   Biology Open

Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome

(2017) Laura Gillard et al.   Frontiers in Physiology

Clinical relevance of the bile acid receptor TGR5 in metabolism

(2017) F Samuel van Nierop et al.   Lancet Diabetes & Endocrinology

Leaky Gut As a Danger Signal for Autoimmune Diseases

(2017) Qinghui Mu et al.   Frontiers in Immunology

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

(2017) Adriana Carino et al.   Scientific Reports

Unravelling the metabolic impact of SBS-associated microbial dysbiosis: Insights from the piglet short bowel syndrome model

(2017) Prue M. Pereira-Fantini et al.   Scientific Reports

Outcome of home parenteral nutrition in 251 children over a 14-y period: report of a single center

(2016) Elie Abi Nader et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The human milk oligosaccharide 2′-fucosyllactose augments the adaptive response to extensive intestinal

(2016) Ethan A. Mezoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome

(2016) Prue M Pereira-Fantini et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Fecal Microbiome in Pediatric Patients With Short Bowel Syndrome

(2016) Zev H. Davidovics et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Intestinal Microbiota Signatures Associated With Histological Liver Steatosis in Pediatric-Onset Intestinal Failure

(2016) Katri Korpela et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression

(2016) Qingli Liu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Features of liver tissue remodeling in intestinal failure during and after weaning off parenteral nutrition

(2016) Annika Mutanen et al.   SURGERY

The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats

(2015) Len Verbeke et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of ileum decreases serum fibroblast growth factor 19 in relation to liver inflammation and fibrosis in pediatric onset intestinal failure

(2015) Annika Mutanen et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome

(2015) Helene Engstrand Lilja et al.   Microbiome

The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid

(2014) J. R. F. Walters et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

(2014) April D. Lake et al.   AMINO ACIDS

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health

(2014) Emily B. Hollister et al.   GASTROENTEROLOGY

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

(2014) Frédéric M. Vaz et al.   HEPATOLOGY

Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans

(2014) Nimzing G. Ladep et al.   HEPATOLOGY

Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease

(2014) Prue M. Pereira-Fantini et al.   JOURNAL OF HEPATOLOGY

Emerging Piglet Models of Neonatal Short Bowel Syndrome

(2014) David W. Lim et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Increased Anti-Flagellin and Anti-Lipopolysaccharide Immunoglobulins in Pediatric Intestinal Failure

(2014) David P. Galloway et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo

(2014) C. M. Cremers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nontumorigenic variant of FGF19 treats cholestatic liver diseases

(2014) J. Luo et al.   Science Translational Medicine

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

Cyclic parenteral nutrition does not change the intestinal microbiota in patients with short bowel syndrome

(2013) Eduarda de Castro Furtado et al.   Acta Cirurgica Brasileira

Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-Like Peptide-2

(2013) Daniel J. Drucker et al.   Annual Review of Physiology

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Persistent abnormal liver fibrosis after weaning off parenteral nutrition in pediatric intestinal failure

(2013) Annika Mutanen et al.   HEPATOLOGY

Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure

(2013) Annika Mutanen et al.   JOURNAL OF HEPATOLOGY

Incidence, Prevention, and Treatment of Parenteral Nutrition–Associated Cholestasis and Intestinal Failure–Associated Liver Disease in Infants and Children

(2013) Giuseppe Lauriti et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Serum 7-Alpha-Hydroxy-4-Cholesten-3-One as a Marker for Bile Acid Loss in Children

(2013) Folke Freudenberg et al.   JOURNAL OF PEDIATRICS

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

Phytosterols Promote Liver Injury and Kupffer Cell Activation in Parenteral Nutrition-Associated Liver Disease

(2013) K. C. El Kasmi et al.   Science Translational Medicine

Intestinal failure-associated liver disease in hospitalised children

(2012) Judith Pichler et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Outcome on home parenteral nutrition for benign intestinal failure: A review of the literature and benchmarking with the European prospective survey of ESPEN

(2012) Loris Pironi et al.   CLINICAL NUTRITION

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Risk factors for small bowel bacterial overgrowth and diagnostic yield of duodenal aspirates in children with intestinal failure: a retrospective review

(2012) Ivan M. Gutierrez et al.   JOURNAL OF PEDIATRIC SURGERY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Perspective: TGR5 (Gpbar-1) in liver physiology and disease

(2012) Verena Keitel et al.   Clinics and Research in Hepatology and Gastroenterology

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine

(2011) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: Bacteriocins and conjugated linoleic acid

(2011) Eileen F. O'Shea et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

Nuclear Receptor Small Heterodimer Partner in Apoptosis Signaling and Liver Cancer

(2011) Yuxia Zhang et al.   Cancers

Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome

(2010) Francisca Joly et al.   BIOCHIMIE

Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition

(2010) Mikko P. Pakarinen et al.   DIGESTIVE AND LIVER DISEASE

Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice

(2010) Galya Vassileva et al.   JOURNAL OF ENDOCRINOLOGY

Plasma metabolomic profile in nonalcoholic fatty liver disease

(2010) Satish C. Kalhan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Potential benefits of pro- and prebiotics on intestinal mucosal immunity and intestinal barrier in short bowel syndrome

(2010) Christos N. Stoidis et al.   NUTRITION RESEARCH REVIEWS

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner

(2009) Dipanjan Chanda et al.   HEPATOLOGY

Intestinal Permeability and Effects of Lactobacillus rhamnosus Therapy in Children With Short Bowel Syndrome

(2009) Timothy A Sentongo et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Inhibition of Nuclear Receptor Small Heterodimer Partner Is Associated With and Regulates Hepatocellular Carcinoma Growth

(2008) Nan He et al.   GASTROENTEROLOGY

Bile acids: Trying to understand their chemistry and biology with the hope of helping patients

(2008) Alan F. Hofmann   HEPATOLOGY

Bile Acid-induced Apoptosis in Hepatocytes Is Caspase-6-dependent

(2008) Christian Rust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome

(2007) Thomas R. Ziegler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY