Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

(2021) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Alzheimer Research, Glucose Metabolism Moves to Center Stage

(2020) Bridget M. Kuehn   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer’s Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study

(2020) Dickson Wong et al.   JOURNAL OF ALZHEIMERS DISEASE

Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer’s Disease

(2020) Hulya Akıncıoğlu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease

(2020) Tatsuhiro Terada et al.   NEUROLOGY

Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders

(2020) Divya Dwivedi et al.   NEUROCHEMICAL RESEARCH

Cerebrospinal Fluid Amyloid Beta, Tau Levels, Apolipoprotein, and 1H-MRS Brain Metabolites in Alzheimer's Disease: A Systematic Review

(2020) Albert Dayor Piersson et al.   ACADEMIC RADIOLOGY

A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy

(2020) Kundlik Gadhave et al.   MEDICINAL RESEARCH REVIEWS

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

Mitochondrial pathways in human health and aging

(2020) Rebecca Bornstein et al.   MITOCHONDRION

Proton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-Analysis

(2020) Thomas Samuel Whitehurst et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Distinctive Neurochemistry in Alzheimer’s Disease via 7 T In Vivo Magnetic Resonance Spectroscopy

(2019) Małgorzata Marjańska et al.   JOURNAL OF ALZHEIMERS DISEASE

Target Enzyme in Alzheimer’s Disease:Acetylcholinesterase Inhibitors

(2019) Mridula Saxena et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis

(2019) Steven Bradburn et al.   AGEING RESEARCH REVIEWS

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

On the central role of mitochondria dysfunction and oxidative stress in Alzheimer’s disease

(2019) Tobore Onojighofia Tobore   NEUROLOGICAL SCIENCES

Creatine as a Neuroprotector: an Actor that Can Play Many Parts

(2019) Eduardo Peil Marques et al.   NEUROTOXICITY RESEARCH

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

(2019) Keisuke Hikosaka et al.   NUTRITIONAL NEUROSCIENCE

Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS

(2019) Deepika Shukla et al.   HUMAN BRAIN MAPPING

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

(2019) Alessandra Webers et al.   IMMUNOLOGY AND CELL BIOLOGY

Brain N-Acetyl Aspartate and associations with cognitive impairment in alcohol dependent patients

(2019) Kirsten C. Morley et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases

(2019) Dhani Raj Chhetri   Frontiers in Pharmacology

Neurochemical profiles in hereditary ataxias: A meta-analysis of Magnetic Resonance Spectroscopy studies

(2019) Janna Krahe et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

(2018) IsaacG Onyango   Neural Regeneration Research

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered brain high-energy phosphate metabolism in mild Alzheimer's disease: A 3-dimensional 31 P MR spectroscopic imaging study

(2018) Anne Rijpma et al.   NeuroImage-Clinical

Magnetic resonance spectroscopy reveals abnormalities of glucose metabolism in the Alzheimer's brain

(2018) Roger Mullins et al.   Annals of Clinical and Translational Neurology

Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study

(2018) Paraskevi Detopoulou et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Multimodal Imaging in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment: Value of Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging of the Posterior Cingulate Region

(2018) Anna Zimny et al.   JOURNAL OF ALZHEIMERS DISEASE

Mapping of Hippocampal pH and Neurochemicals from in vivo Multi-Voxel 31P Study in Healthy Normal Young Male/Female, Mild Cognitive Impairment, and Alzheimer's Disease

(2018) Pravat K. Mandal et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurometabolites and associations with cognitive deficits in mild cognitive impairment: A magnetic resonance spectroscopy study at 7 Tesla

(2018) Georg Oeltzschner et al.   NEUROBIOLOGY OF AGING

In vivo molecular imaging of neuroinflammation in Alzheimer's disease

(2018) Aisling Chaney et al.   JOURNAL OF NEUROCHEMISTRY

Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy

(2018) Sakthivel Sekar et al.   NEUROPHARMACOLOGY

Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer’s Disease: A 7-Year Follow-Up Study

(2017) Masaaki Waragai et al.   JOURNAL OF ALZHEIMERS DISEASE

Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study

(2017) Burcu Zeydan et al.   JOURNAL OF NEUROIMAGING

Oxidative stress and pro-inflammatory cytokines may act as one of the signals for regulating microRNAs expression in Alzheimer’s disease

(2017) Kedar N. Prasad   MECHANISMS OF AGEING AND DEVELOPMENT

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Amyloid in Alzheimer’s Disease: Guilty Beyond Reasonable Doubt?

(2017) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

In vivo functional neurochemistry of human cortical cholinergic function during visuospatial attention

(2017) Michael Lindner et al.   PLoS One

Late-onset Alzheimer’s disease is associated with inherent changes in bioenergetics profiles

(2017) Kai-C. Sonntag et al.   Scientific Reports

Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia

(2016) Shuang-Qing Chen et al.   American Journal of Alzheimers Disease and Other Dementias

1H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease

(2016) Zhongwei Guo et al.   COMPREHENSIVE PSYCHIATRY

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

(2016) Isaac G. Onyango et al.   Aging and Disease

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

(2015) Pravat K. Mandal et al.   BIOLOGICAL PSYCHIATRY

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Brain metabolism assessed via proton magnetic resonance spectroscopy in patients with amnestic or vascular mild cognitive impairment

(2015) Xiaoqun Zhu et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype

(2015) Florian Riese et al.   NEUROBIOLOGY OF AGING

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D1H-MRS in non-demented elders

(2015) Zhenyu Yin et al.   PeerJ

Higher Glutamate + Glutamine and Reduction of N-acetylaspartate in Posterior Cingulate According to Age Range in Patients with Cognitive Impairment and/or Pain

(2014) Nicolás Fayed et al.   ACADEMIC RADIOLOGY

Imaging Neuroinflammation? A Perspective from MR Spectroscopy

(2014) Natalie M. Zahr et al.   BRAIN PATHOLOGY

Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies

(2014) Jonathan Graff-Radford et al.   NEUROBIOLOGY OF AGING

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

(2014) Francesca Calabrese et al.   Frontiers in Cellular Neuroscience

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

(2014) Ya-Ting Chang et al.   Biomed Research International

Glutathione relates to neuropsychological functioning in mild cognitive impairment

(2013) Shantel L. Duffy et al.   Alzheimers & Dementia

α7 Nicotinic Receptor Agonist Enhances Cognition in Aged 3xTg-AD Mice with Robust Plaques and Tangles

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Classification and Epidemiology of MCI

(2013) Rosebud Roberts et al.   CLINICS IN GERIATRIC MEDICINE

Molecular mechanisms of neuropathological changes in Alzheimer’s disease: a review

(2013) Omar Šerý et al.   FOLIA NEUROPATHOLOGICA

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia

(2013) Magdalena G. Targosz-Gajniak et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra

(2013) Caroline D. Rae   NEUROCHEMICAL RESEARCH

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Magnetic resonance spectroscopy in mild cognitive impairment: Systematic review and meta-analysis

(2013) Shankar Tumati et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Contribution of 1H Spectroscopy to a Brief Cognitive-Functional Test Battery for the Diagnosis of Mild Alzheimer’s Disease

(2012) Andrea Silveira de Souza et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Metabolite Investigation in Both Anterior and Posterior Cingulate Gyri in Alzheimer’s Disease Spectrum Using 3-Tesla MR Spectroscopy

(2012) Tae Sung Lim et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The Profile of Hippocampal Metabolites Differs between Alzheimer's Disease and Subcortical Ischemic Vascular Dementia, as Measured by Proton Magnetic Resonance Spectroscopy

(2012) Akihiko Shiino et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotective effects of creatine

(2011) M. Flint Beal   AMINO ACIDS

Neurochemical alterations of the entorhinal cortex in amnestic mild cognitive impairment (aMCI): A three-year follow-up study

(2011) Sang Won Seo et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Elevation of glutathione as a therapeutic strategy in Alzheimer disease

(2011) Chava B. Pocernich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hippocampal Proton MR Spectroscopy in Early Alzheimer’s Disease and Mild Cognitive Impairment

(2011) Catherine M. L. Foy et al.   BRAIN TOPOGRAPHY

Antioxidant Pathways in Alzheimers Disease: Possibilities of Intervention

(2011) J. Vina et al.   CURRENT PHARMACEUTICAL DESIGN

Using proton magnetic resonance spectroscopy to identify mild cognitive impairment

(2011) Tao Wang et al.   INTERNATIONAL PSYCHOGERIATRICS

The neurochemical profile quantified by in vivo 1H NMR spectroscopy

(2011) João M.N. Duarte et al.   NEUROIMAGE

Quantitative multivoxel proton MR spectroscopy study of brain metabolites in patients with amnestic mild cognitive impairment: a pilot study

(2011) Zhong-Xian Yang et al.   NEURORADIOLOGY

Magnetic resonance spectroscopy in the prediction of early conversion from amnestic mild cognitive impairment to dementia: a prospective cohort study

(2011) P. J. Modrego et al.   BMJ Open

Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Useful to Differentiate Amnesic Mild Cognitive Impairment from Alzheimer’s Disease and Healthy Aging

(2010) Toshiyuki Watanabe et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Effects of mitochondrial dysfunction on the immunological properties of microglia

(2010) Annette I Ferger et al.   Journal of Neuroinflammation

Loss of  7 Nicotinic Receptors Enhances  -Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

(2010) C. M. Hernandez et al.   JOURNAL OF NEUROSCIENCE

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

(2010) J. L. O'Brien et al.   NEUROLOGY

Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and alzheimer disease

(2009) Zhiqun Wang et al.   ACTA RADIOLOGICA

Regional Myo-inositol Concentration in Mild Cognitive Impairment Using 1H Magnetic Resonance Spectroscopic Imaging

(2009) Małgorzata Siger et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Baseline MRI Predictors of Conversion from MCI to Probable AD in the ADNI Cohort

(2009) Shannon Risacher et al.   Current Alzheimer Research

Evaluation of functional MRI markers in mild cognitive impairment

(2009) Bing Zhang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

A multicenter 1H-MRS study of the medial temporal lobe in AD and MCI

(2009) F. Jessen et al.   NEUROLOGY

Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy

(2009) Ulrich Pilatus et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Longitudinal Metabolic and Cognitive Changes in Mild Cognitive Impairment Patients

(2008) Brenda L. Bartnik Olson et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Hippocampal Volumes, Proton Magnetic Resonance Spectroscopy Metabolites, and Cerebrovascular Disease in Mild Cognitive Impairment Subtypes

(2008) Kejal Kantarci et al.   ARCHIVES OF NEUROLOGY

Functions and effects of creatine in the central nervous system

(2008) Robert H. Andres et al.   BRAIN RESEARCH BULLETIN

Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Superior to Relative Ratio to Discriminate Alzheimer’s Disease from Binswanger’s Disease

(2008) Toshiyuki Watanabe et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Magnetic Resonance Spectroscopy Performance for Detection of Dementia, Alzheimer’s Disease and Mild Cognitive Impairment in a Community-Based Survey

(2008) J.M. García Santos et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Diffusion Tensor Imaging Correlates with Proton Magnetic Resonance Spectroscopy in Posterior Cingulate Region of Patients with Alzheimer’s Disease

(2008) Bei Ding et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

(2008) Paloma Bermejo et al.   FREE RADICAL RESEARCH

Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria

(2008) L.L. Chao et al.   NEUROBIOLOGY OF AGING

Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases

(2008) Peter J. Adhihetty et al.   NEUROMOLECULAR MEDICINE

Alzheimer Disease: Postmortem Neuropathologic Correlates of Antemortem1H MR Spectroscopy Metabolite Measurements1

(2008) Kejal Kantarci et al.   RADIOLOGY