Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase

(2020) Yechun Xu et al.   Protein & Cell

Differentiation therapy of myeloid leukemia: four decades of development

(2020) Vikas Madan et al.   HAEMATOLOGICA

The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines

(2020) Jeremy Luban et al.   VIRUS RESEARCH

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

(2019) Donatella Boschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dihydroorotate Dehydrogenase as a Target for the Development of Novel Helicobacter pylori-Specific Antimicrobials

(2018) Tomokazu Ohishi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

(2018) Martina Bajzikova et al.   Cell Metabolism

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

(2018) Joseph T. Madak et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

Design, synthesis, and preliminary bioactivity evaluation of N 1 -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors

(2016) Xue Wang et al.   Chemical Biology & Drug Design

Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase

(2016) Makoto Muroi et al.   NATURAL PRODUCT REPORTS

‘Acute myeloid leukemia: a comprehensive review and 2016 update’

(2016) I De Kouchkovsky et al.   Blood Cancer Journal

Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

(2016) Tatsuro Kawamura et al.   Scientific Reports

Proteomic profiling reveals that collismycin A is an iron chelator

(2016) Makoto Kawatani et al.   Scientific Reports

Search for Novel Anti-tumor Agents from Ridaifens Using JFCR39, a Panel of Human Cancer Cell Lines

(2013) Wen-zhi Guo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

(2013) Hélène Munier-Lehmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

Affinity-based target identification for bioactive small molecules

(2013) Makoto Kawatani et al.   MedChemComm

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

(2012) Yushi Futamura et al.   CHEMISTRY & BIOLOGY

Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic Profiling

(2011) Makoto Kawatani et al.   CHEMISTRY & BIOLOGY

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

Systematic isolation of microbial metabolites for natural products depository (NPDepo)

(2011) Hiroyuki Osada et al.   PURE AND APPLIED CHEMISTRY

Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status:In silicoand Biological Evaluations

(2010) Shingo Dan et al.   CANCER RESEARCH

Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action

(2010) Makoto Muroi et al.   CHEMISTRY & BIOLOGY

New P-stereogenic triaminophosphines and their derivatives: synthesis, structure, conformational study, and application as chiral ligands

(2010) Nicolas Toselli et al.   TETRAHEDRON-ASYMMETRY

Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells

(2009) Siro Simizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

(2009) A. Hirayama et al.   CANCER RESEARCH

The Structures of Human Dihydroorotate Dehydrogenase with and without Inhibitor Reveal Conformational Flexibility in the Inhibitor and Substrate Binding Sites†

(2008) Björn Walse et al.   BIOCHEMISTRY

Retinoic acid in development: towards an integrated view

(2008) Karen Niederreither et al.   NATURE REVIEWS GENETICS

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

(2008) M. Kawatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA