Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase

Methyl 3-((6-Methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods

(2015) Hidemitsu Minegishi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells

(2015) M. Breinig et al.   Molecular Systems Biology

A small molecule that induces reactive oxygen species via cellular glutathione depletion

(2014) Tatsuro Kawamura et al.   BIOCHEMICAL JOURNAL

Terpendole E and its Derivative Inhibit STLC- and GSK-1-Resistant Eg5

(2014) Yuka Tarui et al.   CHEMBIOCHEM

NQO2 Is a Reactive Oxygen Species Generating Off-Target for Acetaminophen

(2014) Teemu P. Miettinen et al.   MOLECULAR PHARMACEUTICS

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Label-Free Morphology-Based Prediction of Multiple Differentiation Potentials of Human Mesenchymal Stem Cells for Early Evaluation of Intact Cells

(2014) Hiroto Sasaki et al.   PLoS One

Ribosome Display and Photo-Cross-Linking Techniques for In Vitro Identification of Target Proteins of Bioactive Small Molecules

(2013) Akira Wada et al.   ANALYTICAL CHEMISTRY

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of a Molecular Target of a Novel Fungal Metabolite, Pyrrolizilactone, by Phenotypic Profiling Systems

(2013) Yushi Futamura et al.   CHEMBIOCHEM

“Function-First” Lead Discovery: Mode of Action Profiling of Natural Product Libraries Using Image-Based Screening

(2013) Christopher J. Schulze et al.   CHEMISTRY & BIOLOGY

Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus

(2013) Toshihiko Nogawa et al.   JOURNAL OF ANTIBIOTICS

Target identification of small molecules based on chemical biology approaches

(2013) Yushi Futamura et al.   Molecular BioSystems

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

(2013) Sigrun M. Gustafsdottir et al.   PLoS One

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

(2012) Yushi Futamura et al.   CHEMISTRY & BIOLOGY

Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic Profiling

(2011) Makoto Kawatani et al.   CHEMISTRY & BIOLOGY

Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status:In silicoand Biological Evaluations

(2010) Shingo Dan et al.   CANCER RESEARCH

Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action

(2010) Makoto Muroi et al.   CHEMISTRY & BIOLOGY

Metabolomic Identification of the Target of the Filopodia Protrusion Inhibitor Glucopiericidin A

(2010) Mitsuhiro Kitagawa et al.   CHEMISTRY & BIOLOGY

Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

(2010) Shinichi Nishimura et al.   Nature Chemical Biology

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Cleavable Linker for Photo-Cross-Linked Small-Molecule Affinity Matrix

(2009) Naoki Kanoh et al.   BIOCONJUGATE CHEMISTRY

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA