Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing

Deep diversification of an AAV capsid protein by machine learning

(2021) Drew H. Bryant et al.   NATURE BIOTECHNOLOGY

FDA approves fourth CAR-T cell therapy

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

(2021) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling

(2021) Hongxia Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic Delivery of Nucleic Acids: The case of Ionizable Lipid Nanoparticles

(2021) Michele Schlich et al.   Bioengineering & Translational Medicine

The dawn of mRNA vaccines: The COVID-19 case

(2021) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy

(2021) Tzu-Chieh Ho et al.   Science Advances

In situ cancer vaccination using lipidoid nanoparticles

(2021) Jinjin Chen et al.   Science Advances

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

(2021) Julian D. Gillmore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ex vivo cell-based CRISPR/Cas9 genome editing for therapeutic applications

(2020) Yamin Li et al.   BIOMATERIALS

The challenge and prospect of mRNA therapeutics landscape

(2020) Yuhua Weng et al.   BIOTECHNOLOGY ADVANCES

Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo

(2020) Liu Yang et al.   Molecular Therapy-Nucleic Acids

In Vitro and In Vivo Study of Amphotericin B Formulation with Quaternized Bioreducible Lipidoids

(2020) Fang Liu et al.   ACS Biomaterials-Science & Engineering

Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid Nanoparticles

(2020) Yamin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

(2020) Lei Miao et al.   Nature Communications

Imidazole‐based Synthetic Lipidoids for In Vivo mRNA Delivery into Primary T Lymphocytes

(2020) Xuewei Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA Delivery

(2020) Yamin Li et al.   BIOCONJUGATE CHEMISTRY

Shattering barriers toward clinically meaningful MSC therapies

(2020) Oren Levy et al.   Science Advances

Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection

(2020) Feihe Ma et al.   Science Advances

mRNA Delivery Using Bioreducible Lipidoid Nanoparticles Facilitates Neural Differentiation of Human Mesenchymal Stem Cells

(2020) Xuewei Zhao et al.   Advanced Healthcare Materials

Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

(2020) Xinfu Zhang et al.   Science Advances

Recent advances in the redox-responsive drug delivery nanoplatforms: A chemical structure and physical property perspective

(2020) Shirin Mollazadeh et al.   Materials Science & Engineering C-Materials for Biological Applications

A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases

(2019) Xun Ma et al.   GENE THERAPY

Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery

(2019) Yamin Li et al.   ACS Biomaterials-Science & Engineering

Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles

(2019) Ji Liu et al.   ADVANCED MATERIALS

Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery

(2019) Xin Yang et al.   CHEMICAL REVIEWS

Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins

(2018) Yamin Li et al.   BIOMATERIALS

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Immunogenicity Testing of Lipidoids In Vitro and In Silico : Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

(2018) Anne Marit de Groot et al.   Molecular Therapy-Nucleic Acids

Intracellular Delivery of His-Tagged Genome-Editing Proteins Enabled by Nitrilotriacetic Acid-Containing Lipidoid Nanoparticles

(2018) Yamin Li et al.   Advanced Healthcare Materials

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

(2016) Peng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

(2016) Ming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial library strategies for synthesis of cationic lipid-like nanoparticles and their potential medical applications

(2015) Sarah Altınoglu et al.   Nanomedicine

Biomaterials for mRNA delivery

(2015) Mohammad Ariful Islam et al.   Biomaterials Science

Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Differentiating Neuronal Cells

(2015) Yuji S. Takeda et al.   PLoS One

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced Intracellular siRNA Delivery using Bioreducible Lipid-Like Nanoparticles

(2014) Ming Wang et al.   Advanced Healthcare Materials

Cationic lipids activate intracellular signaling pathways

(2012) Caroline Lonez et al.   ADVANCED DRUG DELIVERY REVIEWS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery

(2012) Ming Wang et al.   ACS Synthetic Biology

NRSF silencing induces neuronal differentiation of human mesenchymal stem cells

(2008) Yinxiang Yang et al.   EXPERIMENTAL CELL RESEARCH

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans

(2008) Stefano Romeo et al.   JOURNAL OF CLINICAL INVESTIGATION