Single‐Component Optogenetic Tools for Inducible RhoA GTPase Signaling

An optogenetic method for interrogating YAP1 and TAZ nuclear–cytoplasmic shuttling

(2021) Anna M. Dowbaj et al.   JOURNAL OF CELL SCIENCE

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

(2020) Iker Lamas et al.   PLOS BIOLOGY

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

(2020) Paul M. Müller et al.   NATURE CELL BIOLOGY

Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

(2020) Alfonso Bolado-Carrancio et al.   eLife

YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility

(2019) Devon E. Mason et al.   JOURNAL OF CELL BIOLOGY

Optically inducible membrane recruitment and signaling systems

(2019) Pimkhuan Hannanta-Anan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

(2019) Halil Bagci et al.   NATURE CELL BIOLOGY

Skeletal cell YAP and TAZ combinatorially promote bone development

(2018) Christopher D. Kegelman et al.   FASEB JOURNAL

Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis

(2018) Emiliano Izquierdo et al.   Nature Communications

Optogenetic Inhibition of Gαq Protein Signaling Reduces Calcium Oscillation Stochasticity

(2018) Pimkhuan Hannanta-anan et al.   ACS Synthetic Biology

Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids

(2018) Spencer T. Glantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

(2018) L. J. Bugaj et al.   SCIENCE

A module for Rac temporal signal integration revealed with optogenetics

(2017) Brian R. Graziano et al.   JOURNAL OF CELL BIOLOGY

Regulation of the Hippo Pathway Transcription Factor TEAD

(2017) Kimberly C. Lin et al.   TRENDS IN BIOCHEMICAL SCIENCES

At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior

(2017) Nicole A. Repina et al.   Annual Review of Chemical and Biomolecular Engineering

Optical control of membrane tethering and interorganellar communication at nanoscales

(2017) Lian He et al.   Chemical Science

Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres

(2017) Patrick W. Oakes et al.   Nature Communications

Optogenetic control of cellular forces and mechanotransduction

(2017) Léo Valon et al.   Nature Communications

Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage

(2016) Elizabeth Wagner et al.   JOURNAL OF CELL BIOLOGY

LOVTRAP: an optogenetic system for photoinduced protein dissociation

(2016) Hui Wang et al.   NATURE METHODS

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis

(2016) Kristýna Kotýnková et al.   Cell Reports

An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis

(2015) Giorgia Guglielmi et al.   DEVELOPMENTAL CELL

Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking

(2015) Felipe O. Bendezú et al.   PLOS BIOLOGY

Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction

(2014) R.J. Marjoram et al.   CURRENT MOLECULAR MEDICINE

Optogenetic protein clustering and signaling activation in mammalian cells

(2013) Lukasz J Bugaj et al.   NATURE METHODS

Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology

(2013) Robert DeRose et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

(2013) X. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insights into the YAP and TEAD complex

(2010) Z. Li et al.   GENES & DEVELOPMENT

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

Constitutively active RhoA inhibits proliferation by retarding G1 to S phase cell cycle progression and impairing cytokinesis

(2009) Pierre Morin et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts

(2008) M. P. Iwanicki et al.   JOURNAL OF CELL SCIENCE