Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

Simple Rho GTPase Dynamics Generate a Complex Regulatory Landscape Associated with Cell Shape

(2020) Cole Zmurchok et al.   BIOPHYSICAL JOURNAL

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Wave patterns organize cellular protrusions and control cortical dynamics

(2019) Yuchuan Miao et al.   Molecular Systems Biology

Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases

(2019) JinSeok Park et al.   Nature Communications

A minimal computational model for three-dimensional cell migration

(2019) Yuansheng Cao et al.   Journal of the Royal Society Interface

Joining forces: crosstalk between biochemical signalling and physical forces orchestrates cellular polarity and dynamics

(2018) Suvrajit Saha et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Actin-Based Cell Protrusion in a 3D Matrix

(2018) Patrick T. Caswell et al.   TRENDS IN CELL BIOLOGY

Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics

(2018) Kaixi Tang et al.   PLoS Computational Biology

Cell Membranes Resist Flow

(2018) Zheng Shi et al.   CELL

Optogenetic dissection of Rac1 and Cdc42 gradient shaping

(2018) S. de Beco et al.   Nature Communications

Control of adhesion and protrusion in cell migration by Rho GTPases

(2018) Harry Warner et al.   CURRENT OPINION IN CELL BIOLOGY

Pulses and waves of contractility

(2017) Min Wu   JOURNAL OF CELL BIOLOGY

An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns

(2017) Melanie Graessl et al.   JOURNAL OF CELL BIOLOGY

The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells

(2017) Michael D. Lovelace et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations

(2017) JinSeok Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns

(2017) William R. Holmes et al.   PLoS Computational Biology

BioNetGen 2.2: advances in rule-based modeling

(2016) Leonard A. Harris et al.   BIOINFORMATICS

Self-organization of actin networks by a monomeric myosin

(2016) Dario Saczko-Brack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flipping the Rac-Rho Switch in Cell Motility

(2016) Leah Edelstein-Keshet   Cell Systems

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

(2016) Kate M. Byrne et al.   Cell Systems

Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics

(2016) Katrin Martin et al.   Scientific Reports

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

(2015) Karen A. Newell-Litwa et al.   JOURNAL OF CELL BIOLOGY

Activator–inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium

(2015) William M. Bement et al.   NATURE CELL BIOLOGY

Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling

(2015) Sulagna Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network-based identification of feedback modules that control RhoA activity and cell migration

(2015) Tae-Hwan Kim et al.   Journal of Molecular Cell Biology

Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration

(2015) Benjamin Lin et al.   Nature Communications

DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks

(2015) Lan K. Nguyen et al.   Scientific Reports

OpenFOAM: Open source CFD in research and industry

(2015) Hrvoje Jasak   International Journal of Naval Architecture and Ocean Engineering

The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1

(2014) Jane Cullis et al.   CANCER CELL

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions

(2014) Jennifer L. Bays et al.   JOURNAL OF CELL BIOLOGY

Mechanical forces and feedbacks in cell motility

(2013) Enas Abu Shah et al.   CURRENT OPINION IN CELL BIOLOGY

Control of the G-protein cascade dynamics by GDP dissociation inhibitors

(2013) Elena Nikonova et al.   Molecular BioSystems

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

(2013) Chuan-Hsiang Huang et al.   NATURE CELL BIOLOGY

From simple to detailed models for cell polarization

(2013) L. Edelstein-Keshet et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Versatile Toolkit to Produce Sensitive FRET Biosensors to Visualize Signaling in Time and Space

(2013) R. D. Fritz et al.   Science Signaling

Identifying Network Motifs that Buffer Front-to-Back Signaling in Polarized Neutrophils

(2013) Yanqin Wang et al.   Cell Reports

From Mechanical Force to RhoA Activation

(2012) Elizabeth C. Lessey et al.   BIOCHEMISTRY

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway

(2012) Caitlin Collins et al.   CURRENT BIOLOGY

FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells

(2012) K. Kunida et al.   JOURNAL OF CELL SCIENCE

The topology design principles that determine the spatiotemporal dynamics of G-protein cascades

(2012) Mikhail A. Tsyganov et al.   Molecular BioSystems

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

(2012) David Meiri et al.   MOLECULAR CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Regimes of wave type patterning driven by refractory actin feedback: transition from static polarization to dynamic wave behaviour

(2012) W R Holmes et al.   PHYSICAL BIOLOGY

Identification of a Novel Actin-Binding Domain within the Rho Guanine Nucleotide Exchange Factor TEM4

(2012) Natalia Mitin et al.   PLoS One

A Comparison of Computational Models for Eukaryotic Cell Shape and Motility

(2012) William R. Holmes et al.   PLoS Computational Biology

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Rho protein crosstalk: another social network?

(2011) Christophe Guilluy et al.   TRENDS IN CELL BIOLOGY

Spatio-temporal Rho GTPase signaling - where are we now?

(2010) O. Pertz   JOURNAL OF CELL SCIENCE

Cells navigate with a local-excitation, global-inhibition-biased excitable network

(2010) Y. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially distributed cell signalling

(2009) Boris N. Kholodenko   FEBS LETTERS

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently

(2009) J. Viaud et al.   MOLECULAR CANCER THERAPEUTICS

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Fast interscale wavelet denoising of Poisson-corrupted images

(2009) Florian Luisier et al.   SIGNAL PROCESSING

Positional Information Generated by Spatially Distributed Signaling Cascades

(2009) Javier Muñoz-García et al.   PLoS Computational Biology

Wave-Pinning and Cell Polarity from a Bistable Reaction-Diffusion System

(2008) Yoichiro Mori et al.   BIOPHYSICAL JOURNAL

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Specificity of Interactions between mDia Isoforms and Rho Proteins

(2008) Michael Lammers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS