An optogenetic method for interrogating YAP1 and TAZ nuclear–cytoplasmic shuttling

Spatio-selective activation of nuclear translocation of YAP with light directs invasion of cancer cell spheroids

(2021) Bernhard Illes et al.   iScience

Parameter estimation in fluorescence recovery after photobleaching: quantitative analysis of protein binding reactions and diffusion

(2021) Daniel E. Williamson et al.   JOURNAL OF MATHEMATICAL BIOLOGY

YAP/TAZ functions and their regulation at a glance

(2020) Arianna Pocaterra et al.   JOURNAL OF CELL SCIENCE

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

(2020) Yi Lu et al.   NATURE CELL BIOLOGY

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

(2019) Rebecca Bertolio et al.   Nature Communications

Parameter estimation in models of biological oscillators: an automated regularised estimation approach

(2019) Jake Alan Pitt et al.   BMC BIOINFORMATICS

New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?

(2019) Michal Shreberk‐Shaked et al.   Molecular Oncology

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

(2019) Danfeng Cai et al.   NATURE CELL BIOLOGY

Nucleocytoplasmic shuttling: the ins and outs of quantitative imaging

(2018) Chris Molenaar et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo

(2018) Samuel A. Manning et al.   CURRENT BIOLOGY

The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

(2018) Xuekun Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Network Motifs Capable of Decoding Transcription Factor Dynamics

(2018) Zongmao Gao et al.   Scientific Reports

Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export

(2018) Nil Ege et al.   Cell Systems

Bringing Light to Transcription: The Optogenetics Repertoire

(2018) Lorena de Mena et al.   Frontiers in Genetics

Optogenetic control of cellular forces and mechanotransduction

(2017) Léo Valon et al.   Nature Communications

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Go in! Go out! Inducible control of nuclear localization

(2016) Barbara Di Ventura et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Importin α1 Mediates Yorkie Nuclear Import via an N-terminal Non-canonical Nuclear Localization Signal

(2016) Shimin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-induced nuclear export reveals rapid dynamics of epigenetic modifications

(2016) Hayretin Yumerefendi et al.   Nature Chemical Biology

LOVTRAP: an optogenetic system for photoinduced protein dissociation

(2016) Hui Wang et al.   NATURE METHODS

Optogenetic control of nuclear protein export

(2016) Dominik Niopek et al.   Nature Communications

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish

(2015) Hannes M. Beyer et al.   ACS Synthetic Biology

Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

(2015) Hayretin Yumerefendi et al.   PLoS One

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

(2014) Veronica A. Codelia et al.   CURRENT BIOLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

(2014) Bi-Chang Chen et al.   SCIENCE

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells

(2014) Dominik Niopek et al.   Nature Communications

Control of Protein Function through Optochemical Translocation

(2014) Hanna Engelke et al.   ACS Synthetic Biology

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Ultraviolet-B-mediated induction of protein–protein interactions in mammalian cells

(2013) Remco P. Crefcoeur et al.   Nature Communications

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

YAP1 oncogene and its eight isoforms

(2012) M Sudol   ONCOGENE

Impulse Control: Temporal Dynamics in Gene Transcription

(2011) Nir Yosef et al.   CELL

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF

(2011) C. Tamm et al.   JOURNAL OF CELL SCIENCE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Signal-dependent dynamics of transcription factor translocation controls gene expression

(2011) Nan Hao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Understanding the temporal codes of intra-cellular signals

(2010) Marcelo Behar et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Rationally improving LOV domain–based photoswitches

(2010) Devin Strickland et al.   NATURE METHODS

Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif

(2009) Tsutomu Oka et al.   GENES TO CELLS

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT