A module for Rac temporal signal integration revealed with optogenetics

Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo

(2016) Clare E. Buckley et al.   DEVELOPMENTAL CELL

PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front

(2016) Trang Thi Thu Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac signal adaptation controls neutrophil mobilization from the bone marrow

(2016) C. C. Campa et al.   Science Signaling

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

(2016) Alba Diz-Muñoz et al.   PLOS BIOLOGY

Rac signal adaptation controls neutrophil mobilization from the bone marrow

(2016) C. C. Campa et al.   Science Signaling

The regulatory subunits of PI3Kγ control distinct neutrophil responses

(2015) Arnaud Deladeriere et al.   Science Signaling

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

(2015) Daniel Schlam et al.   Nature Communications

The regulatory subunits of PI3Kγ control distinct neutrophil responses

(2015) Arnaud Deladeriere et al.   Science Signaling

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

(2014) Yulia Artemenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation

(2014) Mayuki Watanabe et al.   JOURNAL OF IMMUNOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis

(2014) Ming Tang et al.   Nature Communications

The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient

(2014) Ming-Jie Wang et al.   Cell Reports

Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

(2013) Jared E. Toettcher et al.   CELL

ArhGAP15, a Rac-specific GTPase-activating Protein, Plays a Dual Role in Inhibiting Small GTPase Signaling

(2013) Maria Radu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay

(2013) J. A. Brzostowski et al.   JOURNAL OF CELL SCIENCE

Ultrasensitivity of an Adaptive Bacterial Motor

(2013) Junhua Yuan et al.   JOURNAL OF MOLECULAR BIOLOGY

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

(2013) Chuan-Hsiang Huang et al.   NATURE CELL BIOLOGY

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

(2012) Hee Won Yang et al.   MOLECULAR CELL

Adaptation at the output of the chemotaxis signalling pathway

(2012) Junhua Yuan et al.   NATURE

Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway

(2012) K. Takeda et al.   Science Signaling

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

(2011) Jonathan Clark et al.   NATURE METHODS

Light-based feedback for controlling intracellular signaling dynamics

(2011) Jared E Toettcher et al.   NATURE METHODS

Signal processing in complex chemotaxis pathways

(2011) Steven L. Porter et al.   NATURE REVIEWS MICROBIOLOGY

WAVE regulatory complex activation by cooperating GTPases Arf and Rac1

(2011) V. Koronakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2

(2011) M. Mahankali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

(2010) Sa Kan Yoo et al.   DEVELOPMENTAL CELL

Bi-modal Regulation of a Formin by srGAP2

(2010) Frank M. Mason et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotaxis: insights from the extending pseudopod

(2010) P. J. M. Van Haastert   JOURNAL OF CELL SCIENCE

P-Rex1 and Vav1 Cooperate in the Regulation of Formyl-Methionyl-Leucyl-Phenylalanine-Dependent Neutrophil Responses

(2010) C. D. Lawson et al.   JOURNAL OF IMMUNOLOGY

OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca2+ entry

(2009) S. Brechard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Spatiotemporal Regulation of Ras Activity Provides Directional Sensing

(2008) Sheng Zhang et al.   CURRENT BIOLOGY

Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration

(2008) Takanari Inoue et al.   PLoS One

Steering in Quadruplet: The Complex Signaling Pathways Directing Chemotaxis

(2008) E. C. Rericha et al.   Science Signaling