The Contribution of Biomechanical-Biological Interactions of the Spine to Low Back Pain

Spinal pain

(2015) R. Izzo et al.   EUROPEAN JOURNAL OF RADIOLOGY

Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability

(2015) Devina Purmessur et al.   Spine Journal

What Triggers an Episode of Acute Low Back Pain? A Case-Crossover Study

(2015) Daniel Steffens et al.   ARTHRITIS CARE & RESEARCH

TNFα Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs

(2015) Benjamin A. Walter et al.   PLoS One

Structure, function, aging and turnover of aggrecan in the intervertebral disc

(2014) Sarit Sara Sivan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture

(2014) B.A. Walter et al.   JOURNAL OF BIOMECHANICS

ISSLS Prize Winner

(2014) Manos Stefanakis et al.   SPINE

High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain

(2014) Rahul Gawri et al.   ARTHRITIS RESEARCH & THERAPY

Nociceptive neurons detect cytokines in arthritis

(2014) Hans-Georg Schaible   ARTHRITIS RESEARCH & THERAPY

A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift

(2013) D. Purmessur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level

(2013) Cornelia Neidlinger-Wilke et al.   EUROPEAN SPINE JOURNAL

The Effect of Creep on Human Lumbar Intervertebral Disk Impact Mechanics

(2013) David Jamison et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Dynamic and Static Overloading Induce Early Degenerative Processes in Caprine Lumbar Intervertebral Discs

(2013) Cornelis P. L. Paul et al.   PLoS One

Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?

(2013) James C. Iatridis et al.   Spine Journal

Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc

(2013) Aaron J. Fields et al.   Spine Journal

Tolerance of the lumbar spine to shear: A review and recommended exposure limits

(2012) Sean Gallagher et al.   CLINICAL BIOMECHANICS

The Complex Spine

(2012) William S. Marras   HUMAN FACTORS

The role of mechanobiology in tendon healing

(2012) Megan L. Killian et al.   JOURNAL OF SHOULDER AND ELBOW SURGERY

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Annulus Fissures Are Mechanically and Chemically Conducive to the Ingrowth of Nerves and Blood Vessels

(2012) Manos Stefanakis et al.   SPINE

The effects of dynamic loading on the intervertebral disc

(2011) Samantha C. W. Chan et al.   EUROPEAN SPINE JOURNAL

Complex loading affects intervertebral disc mechanics and biology

(2011) B.A. Walter et al.   OSTEOARTHRITIS AND CARTILAGE

Degeneration and regeneration of the intervertebral disc: lessons from development

(2010) L. J. Smith et al.   Disease Models & Mechanisms

Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?

(2010) José García-Cosamalón et al.   JOURNAL OF ANATOMY

Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones

(2009) Toshihiro Sugiyama et al.   BONE

Diurnal variations in intervertebral disc height affect spine flexibility, intradiscal pressure and contact compressive forces in the facet joints

(2009) Thomas Zander et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

A Critical Review of a Pivotal Scientific Contribution: Liles and Associates 24 Years Later

(2008) William S. Marras   HUMAN FACTORS

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

(2008) J. A. Hoyland et al.   RHEUMATOLOGY

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain

(2008) A. J. Freemont   RHEUMATOLOGY

Dynamic Compression Effects on Intervertebral Disc Mechanics and Biology

(2008) Casey L. Korecki et al.   SPINE

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

(2008) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY