Recent advancements in enzyme-mediated crosslinkable hydrogels: In vivo-mimicking strategies

Enzyme-Laden Bioactive Hydrogel for Biocatalytic Monitoring and Regulation

(2021) Xia Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Directed evolution of the transglutaminase from Streptomyces mobaraensis and its enhanced expression in Escherichia coli

(2020) Ting Xue et al.   FOOD BIOTECHNOLOGY

DeeplyTough: Learning Structural Comparison of Protein Binding Sites

(2020) Martin Simonovsky et al.   Journal of Chemical Information and Modeling

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

Bacterial biopolymers: from pathogenesis to advanced materials

(2020) M. Fata Moradali et al.   NATURE REVIEWS MICROBIOLOGY

Genetic Control of Radical Cross-linking in a Semisynthetic Hydrogel

(2020) Austin J. Graham et al.   ACS Biomaterials-Science & Engineering

Dual-Enzyme Crosslinking and Post-polymerization for Printing of Polysaccharide-Polymer Hydrogel

(2020) Saiji Shen et al.   Frontiers in Chemistry

Inflammation-Modulating Hydrogels for Osteoarthritis Cartilage Tissue Engineering

(2020) Rachel H. Koh et al.   Cells

Engineering new catalytic activities in enzymes

(2020) Kai Chen et al.   Nature Catalysis

Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices

(2020) Nicolas Broguiere et al.   ADVANCED MATERIALS

Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals

(2020) Jia Liu et al.   SCIENCE

Bacteria as genetically programmable producers of bioactive natural products

(2020) Joachim J. Hug et al.   Nature Reviews Chemistry

Helical polymers for biological and medical applications

(2020) Thomas Leigh et al.   Nature Reviews Chemistry

Use of a crosslinked casein micelle hydrogel as a carrier for jaboticaba (Myrciaria cauliflora) extract

(2020) Luis Gustavo Lima Nascimento et al.   FOOD HYDROCOLLOIDS

Preparation and characterization of gelatin films by transglutaminase cross-linking combined with ethanol precipitation or Hofmeister effect

(2020) Lin Peng et al.   FOOD HYDROCOLLOIDS

Laccase-mediated construction of flexible double-network hydrogels based on silk fibroin and tyramine-modified hyaluronic acid

(2020) Lin Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair

(2020) Yinji Jin et al.   Materials Science & Engineering C-Materials for Biological Applications

Stable and selective permeable hydrogel microcapsules for high-throughput cell cultivation and enzymatic analysis

(2020) Salvatore Di Girolamo et al.   Microbial Cell Factories

Combining effect of soybean protein isolate and transglutaminase on the gel properties of Zhikong scallop (Chlamys Farreri) adductor muscle

(2020) Hongbo Mi et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Catalytic mechanism of the tyrosinase reaction toward the Tyr98 residue in the caddie protein

(2019) Yasuyuki Matoba et al.   PLOS BIOLOGY

Lipase-catalyzed synthesis of epigallocatechin gallate-based polymer for long-term release of epigallocatechin gallate with antioxidant property

(2019) Sachiko Nitta et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Improving the Performance of Horseradish Peroxidase by Site-Directed Mutagenesis

(2019) Diana Humer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Mussel-Inspired Carboxymethyl Cellulose Hydrogel with Enhanced Adhesiveness through Enzymatic Crosslinking

(2019) Yujie Zhong et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Polymerization of horseradish peroxidase by the laccase-catalyzed tyrosine coupling reaction

(2019) Dani Permana et al.   Biotechnology Journal

Enzyme‐mediated hydrogel encapsulation of single cells for high‐throughput screening and directed evolution of oxidoreductases

(2019) Rosario Vanella et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials

(2019) Jared A. Shadish et al.   NATURE MATERIALS

A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds

(2019) Yi Hong et al.   Nature Communications

End-to-End Differentiable Learning of Protein Structure

(2019) Mohammed AlQuraishi   Cell Systems

DEEPCON: Protein Contact Prediction using Dilated Convolutional Neural Networks with Dropout

(2019) Badri Adhikari   BIOINFORMATICS

ProteinNet: a standardized data set for machine learning of protein structure

(2019) Mohammed AlQuraishi   BMC BIOINFORMATICS

Smart Collagen Hydrogels Based on 1-Ethyl-3-methylimidazolium Acetate and Microbial Transglutaminase for Potential Applications in Tissue Engineering and Cancer Therapy

(2019) Xian Li et al.   ACS Biomaterials-Science & Engineering

Feasibility Study of Tissue Transglutaminase for Self-Catalytic Cross-Linking of Self-Assembled Collagen Fibril Hydrogel and Its Promising Application in Wound Healing Promotion

(2019) Huie Jiang et al.   ACS Omega

Dramatic promotion of wound healing using a recombinant human-like collagen and bFGF cross-linked hydrogel by transglutaminase

(2019) Yayuan Guo et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Off-on switching of enzyme activity by near-infrared light-induced photothermal phase transition of nanohybrids

(2019) Song Zhang et al.   Science Advances

Double-Network Hydrogels Including Enzymatically Crosslinked Poly-(2-alkyl-2-oxazoline)s for 3D Bioprinting of Cartilage-Engineering Constructs

(2019) Lucca Trachsel et al.   BIOMACROMOLECULES

Tailoring swelling of alginate-gelatin hydrogel microspheres by crosslinking with calcium chloride combined with transglutaminase

(2019) Nadezhda Pilipenko et al.   CARBOHYDRATE POLYMERS

Mussel-Inspired Injectable Hydrogel Adhesive Formed under Mild Conditions Features Near-Native Tissue Properties

(2019) Kongchang Wei et al.   ACS Applied Materials & Interfaces

Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation

(2019) Onur Hasturk et al.   BIOMATERIALS

Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels

(2019) Samantha G. Zambuto et al.   MRS Communications

Structure, rheology and functionality of whey protein emulsion gels: Effects of double cross-linking with transglutaminase and calcium ions

(2019) Xiuping Liang et al.   FOOD HYDROCOLLOIDS

Casein-based hydrogels: A mini-review

(2019) Luis Gustavo Lima Nascimento et al.   FOOD CHEMISTRY

Sortase A as a cross-linking enzyme in tissue engineering

(2018) Nicolas Broguiere et al.   Acta Biomaterialia

The Chemistry behind Catechol-Based Adhesion

(2018) Daniel Ruiz-Molina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient preparation of a permanent chitosan/gelatin hydrogel using an acid-tolerant tyrosinase

(2018) Yoo Rae Choi et al.   BIOCHEMICAL ENGINEERING JOURNAL

Versatility of hydrogelation by dual-enzymatic reactions with oxidases and peroxidase

(2018) Masaki Nakahata et al.   BIOCHEMICAL ENGINEERING JOURNAL

mGPfusion: predicting protein stability changes with Gaussian process kernel learning and data fusion

(2018) Emmi Jokinen et al.   BIOINFORMATICS

Tissue adhesive, rapid forming, and sprayable ECM hydrogel via recombinant tyrosinase crosslinking

(2018) Su-Hwan Kim et al.   BIOMATERIALS

Bioprinted gelatin hydrogel platform promotes smooth muscle cell contractile phenotype maintenance

(2018) Ajay Tijore et al.   BIOMEDICAL MICRODEVICES

Circular permutation of a bacterial tyrosinase enables efficient polyphenol-specific oxidation and quantitative preparation of orobol

(2018) Pyung-Gang Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Combined experimental and computational characterization of crosslinked collagen-based hydrogels

(2018) Clara Valero et al.   PLoS One

Directed Evolution of a Bond-Forming Enzyme: Ultrahigh-Throughput Screening of Microbial Transglutaminase Using Yeast Surface Display

(2018) Lukas Deweid et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural basis for highly efficient production of catechol derivatives at acidic pH by tyrosinase from Burkholderia thailandensis

(2018) Hyeoncheol Francis Son et al.   ACS Catalysis

Engineering an Automaturing Transglutaminase with Enhanced Thermostability by Genetic Code Expansion with Two Codon Reassignments

(2018) Kazumasa Ohtake et al.   ACS Synthetic Biology

Dynamic control of hydrogel crosslinking via sortase-mediated reversible transpeptidation

(2018) Matthew R. Arkenberg et al.   Acta Biomaterialia

RiSLnet: Rapid identification of smart mutant libraries using protein structure network. Application to thermal stability enhancement

(2018) Roopali Upadhyay et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biocatalysis by Transglutaminases: A Review of Biotechnological Applications

(2018) Maria Savoca et al.   Micromachines

Optimization and modelling of enzymatic polymerization of ε-caprolactone to polycaprolactone using Candida Antartica Lipase B with response surface methodology and artificial neural network

(2018) Harshini Pakalapati et al.   ENZYME AND MICROBIAL TECHNOLOGY

Learning epistatic interactions from sequence-activity data to predict enantioselectivity

(2017) Julian Zaugg et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A Substrate-Selective Enzyme-Catalysis Assembly Strategy for Oligopeptide Hydrogel-Assisted Combinatorial Protein Delivery

(2017) Tianyue Jiang et al.   NANO LETTERS

Models for biomedical interfaces: a computational study of quinone-functionalized amorphous silica surface features

(2017) Marta Corno et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Non-additive stabilization by halogenated amino acids reveals protein plasticity on a sub-angstrom scale

(2017) Azade S. Hosseini et al.   PROTEIN SCIENCE

Engineered, highly reactive substrates of microbial transglutaminase enable protein labeling within various secondary structure elements

(2017) Natalie M. Rachel et al.   PROTEIN SCIENCE

Control of enzyme reactions by a reconfigurable DNA nanovault

(2017) Guido Grossi et al.   Nature Communications

Orthogonal enzymatic reactions for rapid crosslinking and dynamic tuning of PEG–peptide hydrogels

(2017) Matthew R. Arkenberg et al.   Biomaterials Science

Dynamic hydrogels produced via monoamine oxidase B-catalyzed deamination and aldimine crosslinking for 3D printing

(2017) Qingcong Wei et al.   Journal of Materials Chemistry B

In situ forming gelatin hydrogels by dual-enzymatic cross-linking for enhanced tissue adhesiveness

(2017) Phuong Le Thi et al.   Journal of Materials Chemistry B

A mussel-inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure

(2017) Wei Chen et al.   Journal of Materials Chemistry B

Simple Design of an Enzyme-Inspired Supported Catalyst Based on a Catalytic Triad

(2017) Mitchell D. Nothling et al.   Chem

A tyrosinase, mTyr-CNK, that is functionally available as a monophenol monooxygenase

(2017) Hyunsu Do et al.   Scientific Reports

Hydrogelation of the Short Self-Assembling Peptide I3QGK Regulated by Transglutaminase and Use for Rapid Hemostasis

(2016) Cuixia Chen et al.   ACS Applied Materials & Interfaces

Cell recruiting chemokine-loaded sprayable gelatin hydrogel dressings for diabetic wound healing

(2016) Dong Suk Yoon et al.   Acta Biomaterialia

Role of tissue transglutaminase-2 (TG2)-mediated aminylation in biological processes

(2016) Thung-S. Lai et al.   AMINO ACIDS

Hyaluronic Acid Hydrogels Formed in Situ by Transglutaminase-Catalyzed Reaction

(2016) Adrian Ranga et al.   BIOMACROMOLECULES

Novel enzymatically cross-linked hyaluronan hydrogels support the formation of 3D neuronal networks

(2016) Nicolas Broguiere et al.   BIOMATERIALS

Bio-functionalized silk hydrogel microfluidic systems

(2016) Siwei Zhao et al.   BIOMATERIALS

Enzyme Mimics: Advances and Applications

(2016) Evelyn Kuah et al.   CHEMISTRY-A EUROPEAN JOURNAL

Progress of Mimetic Enzymes and Their Applications in Chemical Sensors

(2016) Bin Yang et al.   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY

Niosome-loaded cold-set whey protein hydrogels

(2016) Arash Abaee et al.   FOOD CHEMISTRY

Inkjetting Plus Peroxidase-Mediated Hydrogelation Produces Cell-Laden, Cell-Sized Particles with Suitable Characters for Individual Applications

(2016) Shinji Sakai et al.   MACROMOLECULAR BIOSCIENCE

A novel smart injectable hydrogel prepared by microbial transglutaminase and human-like collagen: Its characterization and biocompatibility

(2016) Leilei Zhao et al.   Materials Science & Engineering C-Materials for Biological Applications

Light-Triggered Release of Bioactive Molecules from DNA Nanostructures

(2016) Richie E. Kohman et al.   NANO LETTERS

Reaction Pathways in Catechol/Primary Amine Mixtures: A Window on Crosslinking Chemistry

(2016) Juan Yang et al.   PLoS One

Bioprintable, cell-laden silk fibroin–gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs

(2015) Sanskrita Das et al.   Acta Biomaterialia

Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation

(2015) Elena Cambria et al.   BIOMACROMOLECULES

Enzymes: principles and biotechnological applications

(2015) P. K. Robinson   Essays in Biochemistry

Radical-scavenging Activity and Antioxidative Effects of Olive Leaf Components Oleuropein and Hydroxytyrosol in Comparison with Homovanillic Alcohol

(2015) Aya Umeno et al.   Journal of Oleo Science

Tyramine modified alginates via periodate oxidation for peroxidase induced hydrogel formation and immobilization

(2015) Olivera Prodanovic et al.   REACTIVE & FUNCTIONAL POLYMERS

Effect of ultrasound pre-treatment on formation of transglutaminase-catalysed soy protein hydrogel as a riboflavin vehicle for functional foods

(2015) Hao Hu et al.   Journal of Functional Foods

Protein stabilization utilizing a redefined codon

(2015) Kazumasa Ohtake et al.   Scientific Reports

Injectable Degradation-Resistant Hyaluronic Acid Hydrogels Cross-Linked via the Oxidative Coupling of Green Tea Catechin

(2015) Fan Lee et al.   ACS Macro Letters

Engineering Living Functional Materials

(2015) Allen Y. Chen et al.   ACS Synthetic Biology

Structure Based Thermostability Prediction Models for Protein Single Point Mutations with Machine Learning Tools

(2015) Lei Jia et al.   PLoS One

A Fast and Activatable Cross-Linking Strategy for Hydrogel Formation

(2014) Anika M. Jonker et al.   ADVANCED MATERIALS

Acyl transfer mechanisms of tissue transglutaminase

(2014) Jeffrey W. Keillor et al.   BIOORGANIC CHEMISTRY

NeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation

(2014) Manuel Giollo et al.   BMC GENOMICS

Horseradish peroxidase-catalyzed formation of hydrogels from chitosan and poly(vinyl alcohol) derivatives both possessing phenolic hydroxyl groups

(2014) Shinji Sakai et al.   CARBOHYDRATE POLYMERS

Caged Peptides to Control Enzymatic Activity within Hydrogel Scaffolds

(2014) Yuan Lin et al.   CHEMBIOCHEM

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

Tumor Bioengineering Using a Transglutaminase Crosslinked Hydrogel

(2014) Josephine Y. Fang et al.   PLoS One

Crystal Structure of Transglutaminase 2 with GTP Complex and Amino Acid Sequence Evidence of Evolution of GTP Binding Site

(2014) Tae-Ho Jang et al.   PLoS One

Reprogramming the specificity of sortase enzymes

(2014) Brent M. Dorr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immobilization of horseradish peroxidase on electrospun microfibrous membranes for biodegradation and adsorption of bisphenol A

(2013) Ran Xu et al.   BIORESOURCE TECHNOLOGY

Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches

(2013) Susan Molloy et al.   BIOTECHNOLOGY AND BIOENGINEERING

Formation of Core–Shell Particles by Interfacial Radical Polymerization Initiated by a Glucose Oxidase-Mediated Redox System

(2013) Raveesh Shenoy et al.   CHEMISTRY OF MATERIALS

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Enzyme-mediated fast injectable hydrogels based on chitosan–glycolic acid/tyrosine: preparation, characterization, and chondrocyte culture

(2013) Rong Jin et al.   Polymer Chemistry

Polyvinyl alcohol-based hydrogel dressing gellable on-wound via a co-enzymatic reaction triggered by glucose in the wound exudate

(2013) Shinji Sakai et al.   Journal of Materials Chemistry B

Human gelatin tissue-adhesive hydrogels prepared by enzyme-mediated biosynthesis of DOPA and Fe3+ion crosslinking

(2013) Young Chan Choi et al.   Journal of Materials Chemistry B

Rapidly curable chitosan–PEG hydrogels as tissue adhesives for hemostasis and wound healing

(2012) Eugene Lih et al.   Acta Biomaterialia

A biomimetic porous hydrogel of gelatin and glycosaminoglycans cross-linked with transglutaminase and its application in the culture of hepatocytes

(2012) M De Colli et al.   Biomedical Materials

Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing

(2012) Thomas A. Hopf et al.   CELL

An imidazole-based organocatalyst designed for bulk polymerization of lactide isomers: inspiration from Nature

(2012) Olivier Coulembier et al.   CHEMICAL COMMUNICATIONS

A rhodium complex-linked β-barrel protein as a hybrid biocatalyst for phenylacetylene polymerization

(2012) Akira Onoda et al.   CHEMICAL COMMUNICATIONS

Computed microtomography and mechanical property analysis of soy protein porous hydrogel prepared by homogenizing and microbial transglutaminase cross-linking

(2012) Jian Guo et al.   FOOD HYDROCOLLOIDS

Transglutaminase cross-linking to enhance elastic properties of soy protein hydrogels with intercalated montmorillonite nanoclay

(2012) Minfeng Jin et al.   JOURNAL OF FOOD ENGINEERING

Catalytic Mechanism in Artificial Metalloenzyme: QM/MM Study of Phenylacetylene Polymerization by Rhodium Complex Encapsulated in apo-Ferritin

(2012) Zhuofeng Ke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analytical and environmental applications of nanoparticles as enzyme mimetics

(2012) Jianxin Xie et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Crystal Structure ofAgaricus bisporusMushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone

(2011) Wangsa T. Ismaya et al.   BIOCHEMISTRY

Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering

(2011) Liliana S. Moreira Teixeira et al.   BIOMATERIALS

1,2-Benzoquinones in Diels–Alder reactions, dipolar cycloadditions, nucleophilic additions, multicomponent reactions and more

(2011) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

A casein-polysaccharide hybrid hydrogel cross-linked by transglutaminase for drug delivery

(2011) Wenwen Yin et al.   JOURNAL OF MATERIALS SCIENCE

Directed Evolution of Sortase A Mutants with Altered Substrate Selectivity Profiles

(2011) Kirill Piotukh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sortase enzymes in Gram-positive bacteria

(2011) Thomas Spirig et al.   MOLECULAR MICROBIOLOGY

A general strategy for the evolution of bond-forming enzymes using yeast display

(2011) I. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of hepatocyte-embedded hydrogel-filled macroporous scaffold cultures using transglutaminase

(2010) Hiroyuki Ijima et al.   BIOCHEMICAL ENGINEERING JOURNAL

Enzymatic Cross-Linking of a Nanofibrous Peptide Hydrogel

(2010) Erica L. Bakota et al.   BIOMACROMOLECULES

Modular enzymatically crosslinked protein polymer hydrogels for in situ gelation

(2010) Nicolynn E. Davis et al.   BIOMATERIALS

Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran–hyaluronic acid conjugates for cartilage tissue engineering

(2010) R. Jin et al.   BIOMATERIALS

Directed evolution of tyrosinase for enhanced monophenolase/diphenolase activity ratio

(2010) Vered Shuster Ben-Yosef et al.   ENZYME AND MICROBIAL TECHNOLOGY

Injectable enzymatically crosslinked hydrogel system with independent tuning of mechanical strength and gelation rate for drug delivery and tissue engineering

(2010) Motoichi Kurisawa et al.   JOURNAL OF MATERIALS CHEMISTRY

Construction of an Artificial Glutathione Peroxidase Active Site on Copolymer Vesicles

(2010) Yanzhen Yin et al.   MACROMOLECULAR BIOSCIENCE

Allosteric Supramolecular Triple-Layer Catalysts

(2010) H. J. Yoon et al.   SCIENCE

Control of cellular adhesiveness in an alginate-based hydrogel by varying peroxidase and H2O2 concentrations during gelation

(2009) S. Sakai et al.   Acta Biomaterialia

pH-Sensitive Water-Soluble Nanospheric Imprinted Hydrogels Prepared as Horseradish Peroxidase Mimetic Enzymes

(2009) Zhiyong Chen et al.   ADVANCED MATERIALS

Nanospheres with Polymerization Ability Coated by Polyrotaxane

(2009) Motofumi Osaki et al.   JOURNAL OF ORGANIC CHEMISTRY

Polymerization of Phenylacetylene by Rhodium Complexes within a Discrete Space of apo-Ferritin

(2009) Satoshi Abe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single- and Double-Stranded Helical Polymers: Synthesis, Structures, and Functions

(2008) Eiji Yashima et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanoparticulate Glutathione Peroxidase Mimics Based on Selenocystine−Pullulan Conjugates

(2008) Mamoru Haratake et al.   BIOCONJUGATE CHEMISTRY