Enzyme Mimics: Advances and Applications

Nanozymes in bionanotechnology: from sensing to therapeutics and beyond

(2016) Xiaoyu Wang et al.   Inorganic Chemistry Frontiers

Multifunctional Janus Hematite–Silica Nanoparticles: Mimicking Peroxidase-Like Activity and Sensitive Colorimetric Detection of Glucose

(2015) Chang Lu et al.   ACS Applied Materials & Interfaces

Effective Synergistic Effect of Dipeptide-Polyoxometalate-Graphene Oxide Ternary Hybrid Materials on Peroxidase-like Mimics with Enhanced Performance

(2015) Zhuo Ma et al.   ACS Applied Materials & Interfaces

Nickel–Cobalt Oxide Decorated Three-Dimensional Graphene as an Enzyme Mimic for Glucose and Calcium Detection

(2015) Meiyan Wu et al.   ACS Applied Materials & Interfaces

Pd–Ir Core–Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic

(2015) Xiaohu Xia et al.   ACS Nano

Peroxidase-like activity of mesoporous silica encapsulated Pt nanoparticle and its application in colorimetric immunoassay

(2015) Zhifei Wang et al.   ANALYTICA CHIMICA ACTA

Label-free colorimetric sensor for mercury(II) and DNA on the basis of mercury(II) switched-on the oxidase-mimicking activity of silver nanoclusters

(2015) Guang-Li Wang et al.   ANALYTICA CHIMICA ACTA

Intrinsic enzyme mimicking activity of gold nanoclusters upon visible light triggering and its application for colorimetric trypsin detection

(2015) Guang-Li Wang et al.   BIOSENSORS & BIOELECTRONICS

Quest for a turnover mechanism in peptide-based enzyme mimics

(2015) Tsukasa Takahashi et al.   CATALYSIS COMMUNICATIONS

The first 2IB,3IA-heterodifunctionalized β-cyclodextrin derivatives as artificial enzymes

(2015) S. Letort et al.   CHEMICAL COMMUNICATIONS

Biomimetic cavity-based metal complexes

(2015) Jean-Noël Rebilly et al.   CHEMICAL SOCIETY REVIEWS

An enzyme mimic ammonium polymer as a single catalyst for glucose dehydration to 5-hydroxymethylfurfural

(2015) Xueqin Cao et al.   GREEN CHEMISTRY

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

PB@Co3O4 nanoparticles as both oxidase and peroxidase mimics and their application for colorimetric detection of glutathione

(2015) Wenshu Yang et al.   NEW JOURNAL OF CHEMISTRY

An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization

(2015) Rosa Vitale et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Toward a tunable synthetic [FeFe] hydrogenase mimic: single-chain nanoparticles functionalized with a single diiron cluster

(2015) C. A. Tooley et al.   Polymer Chemistry

Carbon coated magnetite nanoparticles with improved water-dispersion and peroxidase-like activity for colorimetric sensing of glucose

(2015) Qian Li et al.   SENSORS AND ACTUATORS B-CHEMICAL

PSS-GN nanocomposites as highly-efficient peroxidase mimics and their applications in colorimetric detection of glucose in serum

(2015) Jing Chen et al.   RSC Advances

Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes

(2014) Youhui Lin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fe-TAML Encapsulated Inside Mesoporous Silica Nanoparticles as Peroxidase Mimic: Femtomolar Protein Detection

(2014) Sushma Kumari et al.   ACS Applied Materials & Interfaces

Catalase Mimic Property of Co3O4 Nanomaterials with Different Morphology and Its Application as a Calcium Sensor

(2014) Jianshuai Mu et al.   ACS Applied Materials & Interfaces

Dual Responsive Enzyme Mimicking Activity of AgX (X = Cl, Br, I) Nanoparticles and Its Application for Cancer Cell Detection

(2014) Guang-Li Wang et al.   ACS Applied Materials & Interfaces

An amplified electrochemical aptasensor for thrombin detection based on pseudobienzymic Fe3O4–Au nanocomposites and electroactive hemin/G-quadruplex as signal enhancers

(2014) Pei Jing et al.   ANALYST

Graphene–palladium nanowires based electrochemical sensor using ZnFe2O4–graphene quantum dots as an effective peroxidase mimic

(2014) Weiyan Liu et al.   ANALYTICA CHIMICA ACTA

A novel enzyme-mimic nanosensor based on quantum dot-Au nanoparticle@silica mesoporous microsphere for the detection of glucose

(2014) Yang Li et al.   ANALYTICA CHIMICA ACTA

Colorimetric determination of sarcosine in urine samples of prostatic carcinoma by mimic enzyme palladium nanoparticles

(2014) Jianming Lan et al.   ANALYTICA CHIMICA ACTA

Artificial enzymes with protein scaffolds: Structural design and modification

(2014) Takashi Matsuo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Catalytic antibodies and their applications in biotechnology: state of the art

(2014) Séverine Padiolleau-Lefèvre et al.   BIOTECHNOLOGY LETTERS

Polypyrrole nanoparticles as promising enzyme mimics for sensitive hydrogen peroxide detection

(2014) Yu Tao et al.   CHEMICAL COMMUNICATIONS

One-pot synthesized DNA-templated Ag/Pt bimetallic nanoclusters as peroxidase mimics for colorimetric detection of thrombin

(2014) Cheng Zheng et al.   CHEMICAL COMMUNICATIONS

Nanocomposite Incorporating V2O5Nanowires and Gold Nanoparticles for Mimicking an Enzyme Cascade Reaction and Its Application in the Detection of Biomolecules

(2014) Konggang Qu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Poly-benzylic Ammonium Chloride Resins as Solid Catalysts for Fructose Dehydration

(2014) Siew Ping Teong et al.   ChemSusChem

Mimicking hydrogenases: From biomimetics to artificial enzymes

(2014) Trevor R. Simmons et al.   COORDINATION CHEMISTRY REVIEWS

In vitro enzyme-mimic activity and in vivo therapeutic potential of HSJ-0017, a novel Mn porphyrin-based antioxidant enzyme mimic

(2014) Bao-qiu Li et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Temperature-Driven Switching of the Catalytic Activity of Artificial Glutathione Peroxidase by the Shape Transition between the Nanotubes and Vesicle-like Structures

(2014) Liang Wang et al.   LANGMUIR

pH dependent catalytic activities of platinum nanoparticles with respect to the decomposition of hydrogen peroxide and scavenging of superoxide and singlet oxygen

(2014) Yi Liu et al.   Nanoscale

Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

(2014) Lizeng Gao et al.   Nanoscale

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

Tuning Polymeric Amphiphilicity via Se-N Interactions: Towards One-Step Double Emulsion for Highly Selective Enzyme Mimics

(2014) Xiaopeng Huang et al.   Small

An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires

(2014) Amit A. Vernekar et al.   Nature Communications

CoxFe3−xO4 hierarchical nanocubes as peroxidase mimetics and their applications in H2O2 and glucose detection

(2014) Wenshu Yang et al.   RSC Advances

Characterization of the antioxidant activity of gold@platinum nanoparticles

(2014) Jo-Won Lee et al.   RSC Advances

Enzyme mimics of spinel-type CoxNi1−xFe2O4 magnetic nanomaterial for eletroctrocatalytic oxidation of hydrogen peroxide

(2013) Liqiang Luo et al.   ANALYTICA CHIMICA ACTA

Irregular-shaped platinum nanoparticles as peroxidase mimics for highly efficient colorimetric immunoassay

(2013) Zhuangqiang Gao et al.   ANALYTICA CHIMICA ACTA

Manganese Porphyrin-dsDNA Complex: A Mimicking Enzyme for Highly Efficient Bioanalysis

(2013) Jie Xu et al.   ANALYTICAL CHEMISTRY

A ferrofluid-based homogeneous assay for highly sensitive and selective detection of single-nucleotide polymorphisms

(2013) Wei Shen et al.   CHEMICAL COMMUNICATIONS

Tuning, inhibiting and restoring the enzyme mimetic activities of Pt–apoferritin

(2013) Unai Carmona et al.   CHEMICAL COMMUNICATIONS

Electrochemical Biosensor Applications of Polysaccharides Chitin and Chitosan

(2013) Wipa Suginta et al.   CHEMICAL REVIEWS

Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources

(2013) Robert-Jan van Putten et al.   CHEMICAL REVIEWS

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes

(2013) Hui Wei et al.   CHEMICAL SOCIETY REVIEWS

Supramolecular catalysis. Part 2: artificial enzyme mimics

(2013) Matthieu Raynal et al.   CHEMICAL SOCIETY REVIEWS

Intracellular Targeting and Pharmacological Activity of the Superoxide Dismutase Mimics MnTE-2-PyP5+ and MnTnHex-2-PyP5+ Regulated by Their Porphyrin Ring Substituents

(2013) Jade B. Aitken et al.   INORGANIC CHEMISTRY

Cut-and-Paste of DNA Using an Artificial Restriction DNA Cutter

(2013) Makoto Komiyama   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Co3O4 nanoparticles as an efficient catalase mimic: Properties, mechanism and its electrocatalytic sensing application for hydrogen peroxide

(2013) Jianshuai Mu et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Generation 9 Polyamidoamine Dendrimer Encapsulated Platinum Nanoparticle Mimics Catalase Size, Shape, and Catalytic Activity

(2013) Xinyu Wang et al.   LANGMUIR

Construction of a highly stable artificial glutathione peroxidase on a protein nanoring

(2013) Lu Miao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hydrazone molecules as mimics for acetylcholinesterase. A new route towards disposable biosensors for pesticides?

(2013) Livia F. Sgobbi et al.   SENSORS AND ACTUATORS B-CHEMICAL

CuS nanoparticles as a mimic peroxidase for colorimetric estimation of human blood glucose level

(2013) Amit Kumar Dutta et al.   TALANTA

Development of biocompatible PAMAM ‘dendrizyme’ to maintain catalytic activity in biological complex medium

(2013) Longgang Wang et al.   Journal of Materials Chemistry B

Catalytic gold nanoparticles for fluorescent detection of mercury(II) and lead(II) ions

(2012) Chen-I Wang et al.   ANALYTICA CHIMICA ACTA

Enzyme Mimics of Au/Ag Nanoparticles for Fluorescent Detection of Acetylcholine

(2012) Chen-I Wang et al.   ANALYTICAL CHEMISTRY

Enantioselective Artificial Metalloenzymes by Creation of a Novel Active Site at the Protein Dimer Interface

(2012) Jeffrey Bos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemiluminescent cholesterol sensor based on peroxidase-like activity of cupric oxide nanoparticles

(2012) Lei Hong et al.   BIOSENSORS & BIOELECTRONICS

Nanoparticulate Peroxidase/Catalase Mimetic and Its Application

(2012) Huimin Deng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular Imprint of Enzyme Active Site by Camel Nanobodies

(2012) Jiang-Wei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclodextrin-derived chalcogenides as glutathione peroxidase mimics and their protection of mitochondria against oxidative damage

(2012) Aiquan Jiao et al.   JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY

Organotellurium-bridged cyclodextrin dimers as artificial glutathione peroxidase models

(2012) Aiquan Jiao et al.   JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY

Dendrimer-Encapsulated Pt Nanoparticles: An Artificial Enzyme for Hydrogen Production

(2012) Tianjun Yu et al.   Journal of Physical Chemistry C

Self-Assembly of a Catalytic Multivalent Peptide–Nanoparticle Complex

(2012) Davide Zaramella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fully-Branched Hyperbranched Polymers with a Diselenide Core as Glutathione Peroxidase Mimics

(2012) Yu Fu et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

(2012) V. Köhler et al.   Nature Chemistry

Vanadium pentoxide nanoparticles mimic vanadium haloperoxidases and thwart biofilm formation

(2012) Filipe Natalio et al.   Nature Nanotechnology

Magnetoferritin nanoparticles for targeting and visualizing tumour tissues

(2012) Kelong Fan et al.   Nature Nanotechnology

BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA

(2012) Ida Schomburg et al.   NUCLEIC ACIDS RESEARCH

Ephedrine-based diselenide: a promiscuous catalyst suitable to mimic the enzyme glutathione peroxidase (GPx) and to promote enantioselective C–C coupling reactions

(2012) Letiére C. Soares et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biomimetic catalysts designed on macromolecular scaffolds

(2012) Yanzhen Yin et al.   PROGRESS IN POLYMER SCIENCE

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Enhanced chemiluminescence of the luminol-hydrogen peroxide system by colloidal cupric oxide nanoparticles as peroxidase mimic

(2012) Wei Chen et al.   TALANTA

Design of Biomimetic Catalysts by Molecular Imprinting in Synthetic Polymers: The Role of Transition State Stabilization

(2011) GÜnter Wulff et al.   ACCOUNTS OF CHEMICAL RESEARCH

A sensitive choline biosensor using Fe3O4 magnetic nanoparticles as peroxidase mimics

(2011) Zhanxia Zhang et al.   ANALYST

Enzyme-Mimic Activity of Ferric Nano-Core Residing in Ferritin and Its Biosensing Applications

(2011) Zhiwen Tang et al.   ANALYTICAL CHEMISTRY

Amplified Detection of MicroRNA Based on Ruthenium Oxide Nanoparticle-Initiated Deposition of an Insulating Film

(2011) Yanfen Peng et al.   ANALYTICAL CHEMISTRY

Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase

(2011) Harald Maid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manganese superoxide dismutase, MnSOD and its mimics

(2011) Sumitra Miriyala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

BSA-stabilized Au clusters as peroxidase mimetics for use in xanthine detection

(2011) Xian-Xiang Wang et al.   BIOSENSORS & BIOELECTRONICS

Peroxidase-Like Activity of Cupric Oxide Nanoparticle

(2011) Wei Chen et al.   ChemCatChem

A carbon nanotube structured biomimetic catalyst for polysaccharide degradation

(2011) Yasuhito Sugano et al.   CHEMICAL COMMUNICATIONS

Mechanism of the oxidation of organic dyes in the presence of nanoceria

(2011) Yanfen Peng et al.   CHEMICAL COMMUNICATIONS

CoFe2O4 magnetic nanoparticles as a peroxidase mimic mediated chemiluminescence for hydrogen peroxide and glucose

(2011) Wenbing Shi et al.   CHEMICAL COMMUNICATIONS

Bio-hydrogen production by different operational modes of dark and photo-fermentation: An overview

(2011) Hidayet Argun et al.   INTERNATIONAL JOURNAL OF HYDROGEN ENERGY

Novel calix[4]arene-based polymeric catalysts as acyltransferase enzyme mimics

(2011) Begum Tabakci et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Autoantibodies with enzymatic properties in human autoimmune diseases

(2011) Bharath Wootla et al.   JOURNAL OF AUTOIMMUNITY

Mimicking Heme Enzymes in the Solid State: Metal–Organic Materials with Selectively Encapsulated Heme

(2011) Randy W. Larsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

(2011) I. Smirnov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic Catalysis

(2011) Louis Marchetti et al.   ACS Catalysis

V2O5 Nanowires with an Intrinsic Peroxidase-Like Activity

(2010) Rute André et al.   ADVANCED FUNCTIONAL MATERIALS

Graphene Oxide: Intrinsic Peroxidase Catalytic Activity and Its Application to Glucose Detection

(2010) Yujun Song et al.   ADVANCED MATERIALS

An Artificial Metalloenzyme: Creation of a Designed Copper Binding Site in a Thermostable Protein

(2010) John Podtetenieff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoregulating Catalytic Activity of Cyclodextrin-Based Artificial Glutathione Peroxidase by Charged Azobenzene

(2010) Ping Wu et al.   CATALYSIS LETTERS

A highly sensitive microRNA biosensor based on ruthenium oxide nanoparticle-initiated polymerization of aniline

(2010) Yanfen Peng et al.   CHEMICAL COMMUNICATIONS

Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

(2010) Francesco G. Mutti et al.   CHEMICAL COMMUNICATIONS

Positively-charged gold nanoparticles as peroxidiase mimic and their application in hydrogen peroxide and glucose detection

(2010) Yun Jv et al.   CHEMICAL COMMUNICATIONS

Nanoceria exhibit redox state-dependent catalase mimetic activity

(2010) Talib Pirmohamed et al.   CHEMICAL COMMUNICATIONS

Label-Free Colorimetric Detection of Single Nucleotide Polymorphism by Using Single-Walled Carbon Nanotube Intrinsic Peroxidase-Like Activity

(2010) Yujun Song et al.   CHEMISTRY-A EUROPEAN JOURNAL

Expression, purification and characterization of cloning-grade zinc finger nuclease

(2010) Andriy Tovkach et al.   JOURNAL OF BIOTECHNOLOGY

Immunological Origin and Functional Properties of Catalytic Autoantibodies to Amyloid β Peptide

(2010) Sudhir Paul et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

(2010) Ting Li et al.   NUCLEIC ACIDS RESEARCH

Magnetic nanoparticle-linked colorimetric aptasensor for the detection of thrombin

(2010) Zhanxia Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles

(2009) Atul Asati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiple catalytic aldolase antibodies suitable for chemical programming

(2009) Rajib Kumar Goswami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nanostructured FeS as a Mimic Peroxidase for Biocatalysis and Biosensing

(2009) Zhihui Dai et al.   CHEMISTRY-A EUROPEAN JOURNAL

High-frequency modification of plant genes using engineered zinc-finger nucleases

(2009) Jeffrey A. Townsend et al.   NATURE

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

(2009) Vipula K. Shukla et al.   NATURE

Designing artificial enzymes by intuition and computation

(2009) Vikas Nanda et al.   Nature Chemistry

A cascade of activity

(2009) Chenxiang Lin et al.   Nature Nanotechnology

Mimicking a Superoxide Dismutase (SOD) Enzyme by copper(II) and zinc(II)-complexes

(2009) Imre Labádi et al.  

Fe3O4Magnetic Nanoparticles as Peroxidase Mimetics and Their Applications in H2O2and Glucose Detection

(2008) Hui Wei et al.   ANALYTICAL CHEMISTRY

Electrochemical Acetylcholine Chloride Biosensor Using an Acetylcholine Esterase Biomimic

(2008) Dipankar Bhattachayay et al.   ANALYTICAL LETTERS

Photoactivated Biotemplated Nanoparticles as an Enzyme Mimic

(2008) Joseph M. Slocik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SOD-like activity of Mn(II) β-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself

(2008) Gilson DeFreitas-Silva et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Catalytic antibodies to HIV: Physiological role and potential clinical utility

(2008) Stephanie Planque et al.   AUTOIMMUNITY REVIEWS

Nanoparticulate Glutathione Peroxidase Mimics Based on Selenocystine−Pullulan Conjugates

(2008) Mamoru Haratake et al.   BIOCONJUGATE CHEMISTRY

Second Generation Biofuels: High-Efficiency Microalgae for Biodiesel Production

(2008) Peer M. Schenk et al.   BioEnergy Research

The role of cerium redox state in the SOD mimetic activity of nanoceria

(2008) Eric G. Heckert et al.   BIOMATERIALS

Chemiluminescence flow biosensor for glucose based on gold nanoparticle-enhanced activities of glucose oxidase and horseradish peroxidase

(2008) Dan Lan et al.   BIOSENSORS & BIOELECTRONICS

An Artificial Supramolecular Nanozyme Based on β-Cyclodextrin-Modified Gold Nanoparticles

(2008) Xiangqiu Li et al.   CATALYSIS LETTERS

Design of Gold Nanoparticle-Based Colorimetric Biosensing Assays

(2008) Weian Zhao et al.   CHEMBIOCHEM

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

How Do Enzymes Really Work?

(2008) Gordon G. Hammes   JOURNAL OF BIOLOGICAL CHEMISTRY

Tethered Dinuclear Europium(III) Macrocyclic Catalysts for the Cleavage of RNA

(2008) Kido Nwe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Critical Evaluation of Acetylcholine Determination in Rat Brain Microdialysates using Ion-Pair Liquid Chromatography with Amperometric Detection

(2008) Dimitri De Bundel et al.   SENSORS

Biomolecule-nanoparticle hybrids for electrochemical biosensors

(2008) S GUO et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

The Chemical Versatility of Natural-Product Assembly Lines

(2007) Christopher T. Walsh   ACCOUNTS OF CHEMICAL RESEARCH

Toward an Artificial Aldolase

(2007) Daniel Font et al.   ORGANIC LETTERS