The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
Authors
Keywords
-
Journal
Frontiers in Cardiovascular Medicine
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-07-26
DOI
10.3389/fcvm.2021.715903
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Reappraising the role of inflammation in heart failure
- (2020) Luigi Adamo et al. Nature Reviews Cardiology
- DNA Sensing in the Innate Immune Response
- (2020) Benoit Briard et al. PHYSIOLOGY
- Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure
- (2020) Dan Hu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress
- (2020) Yan Zhang et al. BIOMEDICINE & PHARMACOTHERAPY
- Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke
- (2020) Qian Li et al. EMBO Molecular Medicine
- Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
- (2020) Yue Quan et al. Oxidative Medicine and Cellular Longevity
- PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease
- (2020) Subhadip Choudhuri et al. PLoS Pathogens
- First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects – a cohort study
- (2020) Lutz Hamann et al. Immunity & Ageing
- Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
- (2020) Dongshan Wan et al. Frontiers in Immunology
- Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
- (2020) Li Zhong et al. Cell Discovery
- Selenium Supplementation Protects Against Lipopolysaccharide-Induced Heart Injury via Sting Pathway in Mice
- (2020) Xuan Wang et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism
- (2020) Yan Gong et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Pathological features of COVID-19-associated myocardial injury: a multicentre cardiovascular pathology study
- (2020) Cristina Basso et al. EUROPEAN HEART JOURNAL
- Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease
- (2020) Coen H. Wiegman et al. Frontiers in Immunology
- Circulating cell-free mitochondrial DNA levels correlate with body mass index and age
- (2020) Santiago D. Padilla-Sánchez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?
- (2020) Jean-Marie Berthelot et al. Frontiers in Immunology
- Immunity and Inflammation in Atherosclerosis
- (2019) Dennis Wolf et al. CIRCULATION RESEARCH
- cGAS in action: Expanding roles in immunity and inflammation
- (2019) Andrea Ablasser et al. SCIENCE
- Drug developers switch gears to inhibit STING
- (2019) Cormac Sheridan NATURE BIOTECHNOLOGY
- LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture
- (2019) Weiwei Ge et al. Journal of Inflammation-London
- cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
- (2019) Haipeng Liu et al. EMBO REPORTS
- The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms
- (2019) Jan Korbecki et al. INFLAMMATION RESEARCH
- Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
- (2019) Lodoe Lama et al. Nature Communications
- STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3
- (2019) Ning Li et al. Redox Biology
- Genomic instability and innate immune responses to self-DNA in progeria
- (2019) Susana Gonzalo et al. GeroScience
- Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles
- (2019) Claire Vanpouille-Box et al. NATURE REVIEWS DRUG DISCOVERY
- European Society of Cardiology: Cardiovascular Disease Statistics 2019
- (2019) Adam Timmis et al. EUROPEAN HEART JOURNAL
- Macrophages in cardiac repair: Environmental cues and therapeutic strategies
- (2019) Geoffrey de Couto EXPERIMENTAL AND MOLECULAR MEDICINE
- Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury
- (2018) Dian J. Cao et al. CIRCULATION
- The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
- (2018) Tuo Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- On taking the STING out of immune activation
- (2018) Andra Banete et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities
- (2018) Sang-Bing Ong et al. PHARMACOLOGY & THERAPEUTICS
- A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin
- (2018) Ray Kreienkamp et al. Cell Reports
- Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response
- (2018) Simona Graziano et al. Nucleus
- A novel anti-malarial drug derivative inhibits cyclic GMP-AMP synthase in Trex1 deficient mice
- (2018) Jie An et al. Arthritis & Rheumatology
- Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response
- (2018) Simona Graziano et al. Nucleus
- Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway
- (2018) Marco Durante et al. Frontiers in Oncology
- Targeting STING with covalent small-molecule inhibitors
- (2018) Simone M. Haag et al. NATURE
- Inflammaging: a new immune–metabolic viewpoint for age-related diseases
- (2018) Claudio Franceschi et al. Nature Reviews Endocrinology
- STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases
- (2018) Lutz Hamann et al. GERONTOLOGY
- The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
- (2018) Senlin Li et al. Cell Reports
- Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death
- (2017) Bridget Larkin et al. JOURNAL OF IMMUNOLOGY
- IRF3 and type I interferons fuel a fatal response to myocardial infarction
- (2017) Kevin R King et al. NATURE MEDICINE
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signalling strength determines proapoptotic functions of STING
- (2017) Muhammet F. Gulen et al. Nature Communications
- The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression
- (2017) Julia M. Weiss et al. OncoImmunology
- Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection
- (2017) Sebastian Aguirre et al. Nature Microbiology
- Inflammation in atherosclerosis
- (2016) Soraya Taleb Archives of Cardiovascular Diseases
- Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells
- (2016) Chih-Hang Anthony Tang et al. CANCER RESEARCH
- 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
- (2016) Piotr Ponikowski et al. EUROPEAN HEART JOURNAL
- Innate immunity in vertebrates: an overview
- (2016) Mario Riera Romo et al. IMMUNOLOGY
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent
- (2016) Kirsten E. Wiens et al. PLoS Pathogens
- Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration
- (2015) Amitava Das et al. AMERICAN JOURNAL OF PATHOLOGY
- Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis
- (2015) Angela C. Collins et al. Cell Host & Microbe
- Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer
- (2015) L. Corrales et al. CLINICAL CANCER RESEARCH
- DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
- (2015) Anetta Härtlova et al. IMMUNITY
- Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
- (2015) Daxing Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interferon-Stimulated Genes: A Complex Web of Host Defenses
- (2014) William M. Schneider et al. Annual Review of Immunology
- STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus
- (2014) Fang Guo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
- (2014) Qiming Liang et al. Cell Host & Microbe
- Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target
- (2014) Enrica Golia et al. Current Atherosclerosis Reports
- Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”
- (2014) Marcello Pinti et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
- (2014) Xin Cai et al. MOLECULAR CELL
- The inflammatory response in myocardial injury, repair and remodelling
- (2014) Nikolaos G. Frangogiannis Nature Reviews Cardiology
- Activated STING in a Vascular and Pulmonary Syndrome
- (2014) Yin Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immune Sensing of DNA
- (2013) Søren R. Paludan et al. IMMUNITY
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
- (2013) John W. Schoggins et al. NATURE
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
- (2013) X.-D. Li et al. SCIENCE
- Endoplasmic Reticulum Stress Regulates the Innate Immunity Critical Transcription Factor IRF3
- (2012) Yi-Ping Liu et al. JOURNAL OF IMMUNOLOGY
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- Evaluation of dose to cardiac structures during breast irradiation
- (2011) M C Aznar et al. BRITISH JOURNAL OF RADIOLOGY
- Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence
- (2010) A. Villaret et al. DIABETES
- Inflammation in Atherosclerosis
- (2009) Peter Libby et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction
- (2008) Stefan Frantz et al. BASIC RESEARCH IN CARDIOLOGY
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
- Origin and physiological roles of inflammation
- (2008) Ruslan Medzhitov NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started