KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition
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Title
KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition
Authors
Keywords
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Journal
iScience
Volume 24, Issue 6, Pages 102649
Publisher
Elsevier BV
Online
2021-05-26
DOI
10.1016/j.isci.2021.102649
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Note: Only part of the references are listed.- mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
- (2021) Yilei Zhang et al. Nature Communications
- Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
- (2021) Guang Lei et al. ONCOGENE
- The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
- (2020) Guang Lei et al. CELL RESEARCH
- Energy-stress-mediated AMPK activation inhibits ferroptosis
- (2020) Hyemin Lee et al. NATURE CELL BIOLOGY
- H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death
- (2020) Yilei Zhang et al. CANCER RESEARCH
- High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)
- (2020) Itsuki Yamaguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery and Optimization of Glucose Uptake Inhibitors
- (2020) Kevin G. Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
- (2020) Liam Baird et al. MOLECULAR AND CELLULAR BIOLOGY
- Visualizing and interpreting cancer genomics data via the Xena platform
- (2020) Mary J. Goldman et al. NATURE BIOTECHNOLOGY
- Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
- (2020) Xiaoguang Liu et al. NATURE CELL BIOLOGY
- Oxidative Stress in Cancer
- (2020) John D. Hayes et al. CANCER CELL
- LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma
- (2019) Ana Galan-Cobo et al. CANCER RESEARCH
- The landscape of cancer cell line metabolism
- (2019) Haoxin Li et al. NATURE MEDICINE
- The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
- (2019) Joseph A. Combs et al. Cancers
- Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors
- (2018) Wenyun Lu et al. ANTIOXIDANTS & REDOX SIGNALING
- NRF2 and the Hallmarks of Cancer
- (2018) Montserrat Rojo de la Vega et al. CANCER CELL
- Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy
- (2018) Adam J. Wolpaw et al. TRENDS IN CELL BIOLOGY
- BAP1 links metabolic regulation of ferroptosis to tumour suppression
- (2018) Yilei Zhang et al. NATURE CELL BIOLOGY
- STIM2 interacts with AMPK and regulates calcium-induced AMPK activation
- (2018) Anoop Singh Chauhan et al. FASEB JOURNAL
- The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate
- (2017) Pranavi Koppula et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation
- (2017) Takeo Goji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
- (2017) Rodrigo Romero et al. NATURE MEDICINE
- CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells
- (2017) Q Wang et al. ONCOGENE
- BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response
- (2017) Fangyan Dai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ROS in Cancer: The Burning Question
- (2017) Iok In Christine Chio et al. TRENDS IN MOLECULAR MEDICINE
- The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
- (2017) Chun-Shik Shin et al. Nature Communications
- Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
- (2017) Zhen-Dong Xiao et al. Nature Communications
- Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
- (2017) Alexander Muir et al. eLife
- Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
- (2017) Volkan I Sayin et al. eLife
- lncRNANBR2modulates cancer cell sensitivity to phenformin through GLUT1
- (2016) Xiaowen Liu et al. CELL CYCLE
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress
- (2016) Xiaowen Liu et al. NATURE CELL BIOLOGY
- Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance
- (2016) Youngtae Jeong et al. Cancer Discovery
- BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21
- (2016) Hyemin Lee et al. Oncotarget
- The complexity of the Nrf2 pathway: beyond the antioxidant response
- (2015) Ying Huang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
- (2015) F. Skoulidis et al. Cancer Discovery
- FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway
- (2014) Aifu Lin et al. CANCER RESEARCH
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress
- (2013) A Lin et al. ONCOGENE
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
- (2012) T Yamadori et al. ONCOGENE
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
- (2010) Boyi Gan et al. CANCER CELL
- Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
- (2010) G. P. Sykiotis et al. Science Signaling
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