The Mechanism of Oral Melatonin Ameliorates Intestinal and Adipose Lipid Dysmetabolism Through Reducing Escherichia Coli-Derived Lipopolysaccharide

Pharmacological aspects of ANGPTL3 and ANGPTL4 inhibitors: New therapeutic approaches for the treatment of atherogenic dyslipidemia

(2020) Massimiliano Ruscica et al.   PHARMACOLOGICAL RESEARCH

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

(2020) Kristian K. Kristensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy

(2020) Marta Garaulet et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

(2020) Zhigang Liu et al.   Nature Communications

Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet

(2020) Jie Yin et al.   mSystems

Reduced delivery of epididymal adipocyte-derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice

(2019) Bohan Rong et al.   JOURNAL OF PINEAL RESEARCH

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection

(2019) Eric M. Velazquez et al.   Nature Microbiology

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

(2019) Amandine Everard et al.   Nature Communications

Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice

(2019) Daniel Jahn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass

(2019) D. Nyasha Chagwedera et al.   Cell Metabolism

Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin‐1β

(2019) Giuseppe Mannino et al.   JOURNAL OF PINEAL RESEARCH

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

(2019) Louise B. Thingholm et al.   Cell Host & Microbe

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

(2019) Junki Miyamoto et al.   Nature Communications

Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

(2019) Eirini Giannoudaki et al.   Nature Communications

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

(2018) Francesca Cignarella et al.   Cell Metabolism

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

(2018) Eleni Beli et al.   DIABETES

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

(2018) Aafke W. F. Janssen et al.   DIABETOLOGIA

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis in Mice via a Toll-Like Receptor 4/p21-Activated Kinase 1 Cascade

(2018) Yaxin Wu et al.   DIGESTIVE DISEASES AND SCIENCES

Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195

(2018) Lan Xiao et al.   GASTROENTEROLOGY

DoesAkkermansia muciniphilaplay a role in type 1 diabetes?

(2018) Gilles Mithieux   GUT

Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction

(2018) Tuo Shao et al.   JOURNAL OF HEPATOLOGY

Flavonoids inhibit both rice and sheep serotonin N -acetyltransferases and reduce melatonin levels in plants

(2018) Kyungjin Lee et al.   JOURNAL OF PINEAL RESEARCH

Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses’ Health Study II

(2018) Céline Vetter et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Interorgan Metabolic Crosstalk in Human Insulin Resistance

(2018) Sofiya Gancheva et al.   PHYSIOLOGICAL REVIEWS

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

(2018) Viktoria Gusarova et al.   Nature Communications

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis

(2018) Abhishek K. Singh et al.   Molecular Metabolism

The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis

(2018) Agnieszka D. Truax et al.   Cell Host & Microbe

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet-fed mice

(2018) Jie Yin et al.   JOURNAL OF PINEAL RESEARCH

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

(2018) Kairui Mao et al.   NATURE

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

(2018) Alessandro Scopelliti et al.   Cell Metabolism

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism

(2018) Rong Bohan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Melatonin promotes circadian rhythm-induced proliferation through Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway

(2017) Longsen Han et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

(2017) Yuhao Wang et al.   SCIENCE

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

(2017) Elaine Xu et al.   Nature Communications

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP

(2017) Bodil Ingerslev et al.   Molecular Metabolism

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of Akkermansia muciniphila in Genetic-Induced HyperlipidemiaHighlights

(2016) Jing Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

(2016) Dorien Reijnders et al.   Cell Metabolism

Regulation of lipid metabolism by angiopoietin-like proteins

(2016) Wieneke Dijk et al.   CURRENT OPINION IN LIPIDOLOGY

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease

(2016) Duane R. Wesemann et al.   IMMUNITY

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis inEscherichia coli

(2016) Akintunde Emiola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary Polyphenols Promote Growth of the Gut BacteriumAkkermansia muciniphilaand Attenuate High-Fat Diet–Induced Metabolic Syndrome

(2015) Diana E. Roopchand et al.   DIABETES

Integrative systems analysis of diet-induced obesity identified a critical transition in the transcriptomes of the murine liver and epididymal white adipose tissue

(2015) J Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Pinealectomy interferes with the circadian clock genes expression in white adipose tissue

(2015) Talita da Silva Mendes de Farias et al.   JOURNAL OF PINEAL RESEARCH

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

(2015) Wieneke Dijk et al.   eLife

Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome

(2014) Amir Zarrinpar et al.   Cell Metabolism

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

A new model of the role of psychological and emotional distress in promoting obesity: conceptual review with implications for treatment and prevention

(2014) E. Hemmingsson   Obesity Reviews

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

(2014) M. Catoire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy

(2013) Miao Lin et al.   KIDNEY INTERNATIONAL

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion

(2013) Frits Mattijssen et al.   Molecular Metabolism

Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium

(2012) D.-H. Kim et al.   DIABETES

Microbes inside—from diversity to function: the case of Akkermansia

(2012) Clara Belzer et al.   ISME Journal

MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction

(2012) N. Warner et al.   JOURNAL OF IMMUNOLOGY

Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption

(2012) O. M. Buxton et al.   Science Translational Medicine

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

(2010) Laeticia Lichtenstein et al.   Cell Metabolism

P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance

(2010) C. Sato et al.   DIABETES

Postprandial remodeling of the gut microbiota in Burmese pythons

(2010) Elizabeth K Costello et al.   ISME Journal

Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor

(2009) M. Hashizume et al.   ANNALS OF THE RHEUMATIC DISEASES

Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism

(2009) Suneil K. Koliwad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Frog transparency led to discovery of melatonin

(2008) Thomas C. Erren et al.   NATURE