Journal
CANCER LETTERS
Volume 278, Issue 1, Pages 34-40Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.12.020
Keywords
Angiogenesis; Human cancer cell; Aortic ring; Endothelial cell; 1,4-Naphthoquinone
Categories
Funding
- Academic Frontier Project for Private Universities (Kobe-Gakuin University)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [2006-2010, 18700608]
- Industrial Technology Research Program from NEDO, Japan [08A01017a]
- Grants-in-Aid for Scientific Research [18700608] Funding Source: KAKEN
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Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis-dependent diseases including cancer. Vitamin K2 and K3, which are naphthoquinone derivatives, inhibit angiogenesis. We examined the anti-cancer and anti-angiogenic effects of naphthoquinones and its structurally related compounds. Among these 13 compounds, 1,4-naphthoquinone strongly inhibited both human colon cancer cell (HCT116) growth and angiogenesis. To clarify the anti-angiogenic mechanism, the effects of 1,4-naphthoquinone on human umbilical vein endothelial cell (HUVEC) tube formation, proliferation and chemotaxis were examined. Consequently, 1,4-naphthoquinone inhibited HUVEC functions. These results suggest that 1,4-naphthoquinone may be useful to cancer therapy. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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