Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling

Playing polo during mitosis: PLK1 takes the lead

(2017) G Combes et al.   ONCOGENE

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics

(2016) Rosie Elizabeth Ann Gutteridge et al.   MOLECULAR CANCER THERAPEUTICS

Plumbagin Inhibits Prostate Carcinogenesis in Intact and Castrated PTEN Knockout Mice via Targeting PKC , Stat3, and Epithelial-to-Mesenchymal Transition Markers

(2015) B. B. Hafeez et al.   Cancer Prevention Research

Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma

(2015) Shinya Ohashi et al.   GASTROENTEROLOGY

Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression

(2015) Mingshan Niu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

(2015) Shu-Feng Zhou et al.   Drug Design Development and Therapy

Plk1 Inhibition Enhances the Efficacy of Androgen Signaling Blockade in Castration-Resistant Prostate Cancer

(2014) Z. Zhang et al.   CANCER RESEARCH

Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State

(2014) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Anticancer Compound Plumbagin and Its Molecular Targets: A Structural Insight into the Inhibitory Mechanisms Using Computational Approaches

(2014) Mohammad S. Jamal et al.   PLoS One

Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions

(2014) Wei Yan et al.   Bone Research

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

(2013) Yan-Cong Li et al.   CANCER LETTERS

Epidemiology of Esophageal Cancer in Japan and China

(2013) Yingsong Lin et al.   JOURNAL OF EPIDEMIOLOGY

Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways

(2012) Bilal Bin Hafeez et al.   INTERNATIONAL JOURNAL OF CANCER

Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cellsin vivo

(2012) Sutapa Sinha et al.   INTERNATIONAL JOURNAL OF CANCER

Plumbagin, a medicinal plant (lumbago zeylanica )-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model

(2012) Bilal Bin Hafeez et al.   Molecular Oncology

Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2

(2011) Li Lai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reciprocal Activation Between PLK1 and Stat3 Contributes to Survival and Proliferation of Esophageal Cancer Cells

(2011) Yu Zhang et al.   GASTROENTEROLOGY

Plumbagin Inhibits Osteoclastogenesis and Reduces Human Breast Cancer-Induced Osteolytic Bone Metastasis in Mice through Suppression of RANKL Signaling

(2011) B. Sung et al.   MOLECULAR CANCER THERAPEUTICS

Apoptosis Inducing Effect of Plumbagin on Colonic Cancer Cells Depends on Expression of COX-2

(2011) Bharathi Raja Subramaniya et al.   PLoS One

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics

(2009) Puneet Chopra et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plumbagin, a Medicinal Plant–Derived Naphthoquinone, Is a Novel Inhibitor of the Growth and Invasion of Hormone-Refractory Prostate Cancer

(2008) Moammir H. Aziz et al.   CANCER RESEARCH

Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma

(2008) Yan-Bin Feng et al.   INTERNATIONAL JOURNAL OF CANCER

Plumbagin-induced Apoptosis in Human Prostate Cancer Cells is Associated with Modulation of Cellular Redox Status and Generation of Reactive Oxygen Species

(2008) Anna A. Powolny et al.   PHARMACEUTICAL RESEARCH