Glycans in Virus-Host Interactions: A Structural Perspective

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

(2021) Paul-Albert Koenig et al.   SCIENCE

A cross-neutralizing antibody between HIV-1 and influenza virus

(2021) Chang-Chun D. Lee et al.   PLoS Pathogens

A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo

(2020) Evelyn M. Covés-Datson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microarray Strategies for Exploring Bacterial Surface Glycans and Their Interactions With Glycan-Binding Proteins

(2020) María Asunción Campanero-Rhodes et al.   Frontiers in Microbiology

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

(2020) Gemma E. Seabright et al.   STRUCTURE

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

(2020) Yasunori Watanabe et al.   Nature Communications

Emergence and significance of carbohydrate-specific antibodies

(2020) Katharina Kappler et al.   GENES AND IMMUNITY

Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity

(2020) Daniel W. Heindel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of the HIV-1 Env glycan shield across scales

(2020) Zachary T. Berndsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope

(2019) Feng Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

(2019) Goran Bajic et al.   Cell Host & Microbe

Protein and Glycan Mimicry in HIV Vaccine Design

(2019) Gemma E. Seabright et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

(2019) Meghan O. Altman et al.   mBio

Engineering of a Lectibody Targeting High-Mannose-Type Glycans of the HIV Envelope

(2019) Krystal Teasley Hamorsky et al.   MOLECULAR THERAPY

Glycosylator: a Python framework for the rapid modeling of glycans

(2019) Thomas Lemmin et al.   BMC BIOINFORMATICS

New insights in Type I and II CD20 antibody mechanisms-of-action with a panel of novel CD20 antibodies

(2018) Saskia Meyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope

(2018) Kannan Tharakaraman et al.   Cell Host & Microbe

Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen

(2018) Tim Rollenske et al.   NATURE IMMUNOLOGY

A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

(2018) Nicholas C. Wu et al.   Nature Communications

Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan

(2018) Roux-Cil Ferreira et al.   Scientific Reports

N-Glycosylation of Seasonal Influenza Vaccine Hemagglutinins: Implication for Potency Testing and Immune Processing

(2018) Yanming An et al.   JOURNAL OF VIROLOGY

Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield

(2017) Thomas Lemmin et al.   STRUCTURE

Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going?

(2017) Michael J. E. Marshall et al.   Frontiers in Immunology

Conformational Heterogeneity of the HIV Envelope Glycan Shield

(2017) Mingjun Yang et al.   Scientific Reports

Lessons learned from comparing molecular dynamics engines on the SAMPL5 dataset

(2016) Michael R. Shirts et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual

(2016) Karen P. Coss et al.   JOURNAL OF VIROLOGY

Delineating the conformational flexibility of trisaccharides from NMR spectroscopy experiments and computer simulations

(2016) Mingjun Yang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

(2016) Anna M. Gram et al.   PLoS Pathogens

Avian influenza viruses in humans

(2016) J.S. MALIK PEIRIS   REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES

GS-align for glycan structure alignment and similarity measurement

(2015) Hui Sun Lee et al.   BIOINFORMATICS

The HIV glycan shield as a target for broadly neutralizing antibodies

(2015) Katie J. Doores   FEBS Journal

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans

(2015) Fernando Garces et al.   IMMUNITY

Role of stem glycans attached to haemagglutinin in the biological characteristics of H5N1 avian influenza virus

(2015) Xiaojian Zhang et al.   JOURNAL OF GENERAL VIROLOGY

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

(2015) Julian K-C. Ma et al.   PLANT BIOTECHNOLOGY JOURNAL

Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies

(2014) Fernando Garces et al.   CELL

Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose

(2014) Robyn L Stanfield et al.   GLYCOBIOLOGY

Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers

(2014) Emilia Falkowska et al.   IMMUNITY

Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single-Particle Electron Microscopy

(2014) C. D. Murin et al.   JOURNAL OF VIROLOGY

The sweet spot: defining virus–sialic acid interactions

(2014) Jennifer E. Stencel-Baerenwald et al.   NATURE REVIEWS MICROBIOLOGY

Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus

(2014) Rahul Raman et al.   TRENDS IN MICROBIOLOGY

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

(2014) Michelle Tate et al.   Viruses-Basel

Entry of hepatitis B and C viruses — recent progress and future impact

(2014) Thomas F Baumert et al.   Current Opinion in Virology

Investigating virus–glycan interactions using glycan microarrays

(2014) David F Smith et al.   Current Opinion in Virology

Glycan Engagement by Viruses: Receptor Switches and Specificity

(2014) Luisa J. Ströh et al.   Annual Review of Virology

N-Linked Glycosylation of the Hemagglutinin Protein Influences Virulence and Antigenicity of the 1918 Pandemic and Seasonal H1N1 Influenza A Viruses

(2013) X. Sun et al.   JOURNAL OF VIROLOGY

Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles

(2013) Charlermchai Artpradit et al.   VIRUS RESEARCH

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

(2013) Yunji Wu et al.   Cell Reports

Restricted N-glycan Conformational Space in the PDB and Its Implication in Glycan Structure Modeling

(2013) Sunhwan Jo et al.   PLoS Computational Biology

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

(2013) Jean-Philippe Julien et al.   PLoS Pathogens

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies?

(2012) Nicolai Bovin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

2G12-Expressing B Cell Lines May Aid in HIV Carbohydrate Vaccine Design Strategies

(2012) K. J. Doores et al.   JOURNAL OF VIROLOGY

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

(2012) H. Mouquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An overview of Influenza A virus receptors

(2011) Shengqiang Ge et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Mouse LSECtin as a model for a human Ebola virus receptor

(2011) Z. Pipirou et al.   GLYCOBIOLOGY

CHARMM Additive All-Atom Force Field for Carbohydrate Derivatives and Its Utility in Polysaccharide and Carbohydrate–Protein Modeling

(2011) Olgun Guvench et al.   Journal of Chemical Theory and Computation

Extensive Determination of Glycan Heterogeneity Reveals an Unusual Abundance of High Mannose Glycans in Enriched Plasma Membranes of Human Embryonic Stem Cells

(2011) Hyun Joo An et al.   MOLECULAR & CELLULAR PROTEOMICS

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

(2011) Camille Bonomelli et al.   PLoS One

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

A dimeric form of the HIV-1 antibody 2G12 elicits potent antibody-dependent cellular cytotoxicity

(2010) Joshua S Klein et al.   AIDS

Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan–protein complexes

(2010) Robert J Woods et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans

(2010) D Cameron Dunlop et al.   GLYCOBIOLOGY

Very Few Substitutions in a Germ Line Antibody Are Required To Initiate Significant Domain Exchange

(2010) Michael Huber et al.   JOURNAL OF VIROLOGY

Quaternary Epitope Specificities of Anti-HIV-1 Neutralizing Antibodies Generated in Rhesus Macaques Infected by the Simian/Human Immunodeficiency Virus SHIVSF162P4

(2010) J. E. Robinson et al.   JOURNAL OF VIROLOGY

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

(2010) R. Pejchal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design

(2010) C.-J. Wei et al.   Science Translational Medicine

The influenza A virus hemagglutinin glycosylation state affects receptor-binding specificity

(2010) Robert P. de Vries et al.   VIROLOGY

Anti-carbohydrate antibodies of normal sera: Findings, surprises and challenges

(2009) Margaret E. Huflejt et al.   MOLECULAR IMMUNOLOGY

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Macromolecular Modeling with Rosetta

(2008) Rhiju Das et al.   Annual Review of Biochemistry

Design and Expression of a Dimeric Form of Human Immunodeficiency Virus Type 1 Antibody 2G12 with Increased Neutralization Potency

(2008) A. P. West et al.   JOURNAL OF VIROLOGY

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE