A cross-neutralizing antibody between HIV-1 and influenza virus

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

(2020) Nicholas C. Wu et al.   Nature Communications

Human Influenza Virus Hemagglutinins Contain Conserved Oligomannose N-Linked Glycans Allowing Potent Neutralization by Lectins

(2020) Andrew J. Thompson et al.   Cell Host & Microbe

Site-specific glycan analysis of the SARS-CoV-2 spike

(2020) Yasunori Watanabe et al.   SCIENCE

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

(2020) Gemma E. Seabright et al.   STRUCTURE

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

(2020) Yasunori Watanabe et al.   Nature Communications

Exploitation of glycosylation in enveloped virus pathobiology

(2019) Yasunori Watanabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein and Glycan Mimicry in HIV Vaccine Design

(2019) Gemma E. Seabright et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

(2019) Meghan O. Altman et al.   mBio

An MPER antibody neutralizes HIV-1 using germline features shared among donors

(2019) Lei Zhang et al.   Nature Communications

Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans

(2019) Seth J. Zost et al.   Cell Reports

Structure and Immune Recognition of the HIV Glycan Shield

(2018) Max Crispin et al.   Annual Review of Biophysics

Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice

(2018) Xilin Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of the Lassa virus glycan shield provides a model for immunological resistance

(2018) Yasunori Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope

(2018) Christopher O. Barnes et al.   Nature Communications

A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

(2018) Nicholas C. Wu et al.   Nature Communications

Structural analysis of glycoproteins: building N-linked glycans with Coot

(2018) Paul Emsley et al.   Acta Crystallographica Section D-Structural Biology

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

(2018) Liwei Cao et al.   Nature Communications

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

(2018) Weston B. Struwe et al.   Cell Reports

Recent progress in broadly neutralizing antibodies to HIV

(2018) Devin Sok et al.   NATURE IMMUNOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts

(2018) David Oyen et al.   Science Advances

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

(2017) Jeong Hyun Lee et al.   IMMUNITY

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus

(2017) Nicholas C. Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for antibody-mediated neutralization of Lassa virus

(2017) Kathryn M. Hastie et al.   SCIENCE

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

(2017) Natalia T. Freund et al.   Science Translational Medicine

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

(2017) Nicholas C. Wu et al.   Nature Communications

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

(2017) Yuan Yuan et al.   Nature Communications

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

(2017) Nicholas C. Wu et al.   PLoS Pathogens

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

(2016) Dennis R. Burton et al.   Annual Review of Immunology

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

(2016) M. Gordon Joyce et al.   CELL

Hepatitis C Virus Is Released via a Noncanonical Secretory Route

(2016) Karen Bayer et al.   JOURNAL OF VIROLOGY

Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions

(2016) Kshitij Khatri et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular insights into the inhibition of HIV-1 infection using a CD4 domain-1-specific monoclonal antibody

(2015) Wangheng Hou et al.   ANTIVIRAL RESEARCH

Glycosylation Analysis of Engineered H3N2 Influenza A Virus Hemagglutinins with Sequentially Added Historically Relevant Glycosylation Sites

(2015) Yanming An et al.   JOURNAL OF PROTEOME RESEARCH

Human Lectins and Their Roles in Viral Infections

(2015) Christopher Mason et al.   MOLECULES

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

(2015) Alexander Rouvinski et al.   NATURE

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy

(2015) Jeong Hyun Lee et al.   STRUCTURE

Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies

(2015) Nicholas E. Webb et al.   Nature Communications

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

(2015) Laura K. Pritchard et al.   Nature Communications

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies

(2014) Fernando Garces et al.   CELL

Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single-Particle Electron Microscopy

(2014) C. D. Murin et al.   JOURNAL OF VIROLOGY

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

(2014) Devin Sok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

(2014) Peter S. Lee et al.   Nature Communications

Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1–neutralizing activity

(2013) Ruijiang Song et al.   NATURE BIOTECHNOLOGY

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

(2013) Leopold Kong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization

(2013) I. S. Georgiev et al.   SCIENCE

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

A Blueprint for HIV Vaccine Discovery

(2012) Dennis R. Burton et al.   Cell Host & Microbe

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

(2012) H. Mouquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection

(2011) Wei-Chuan Chang et al.   BMC IMMUNOLOGY

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Steric Shielding of Surface Epitopes and Impaired Immune Recognition Induced by the Ebola Virus Glycoprotein

(2010) Joseph R. Francica et al.   PLoS Pathogens

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin

(2008) Manabu Igarashi et al.   VIROLOGY