SARS-CoV-2: is there neuroinvasion?

Genetic Variants of SARS-CoV-2—What Do They Mean?

(2021) Adam S. Lauring et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neuroinvasion of SARS-CoV-2 in human and mouse brain

(2021) Eric Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-like receptor 4 mediates blood-brain barrier permeability and disease in C3H mice during Venezuelan equine encephalitis virus infection

(2021) Bradley S. Hollidge et al.   Virulence

New variant of SARS-CoV-2 in UK causes surge of COVID-19

(2021) Tony Kirby   Lancet Respiratory Medicine

Neurological Manifestation of SARS-CoV-2 Induced Inflammation and Possible Therapeutic Strategies Against COVID-19

(2021) Dipak Kumar et al.   MOLECULAR NEUROBIOLOGY

COVID-19 survivor experiencing long-term symptoms

(2021) Tony Kirby   Lancet Respiratory Medicine

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants

(2021) Rui Wang et al.   Communications Biology

SARS-CoV-2 journey to the brain with a focus on potential role of docosahexaenoic acid bioactive lipid mediators

(2021) Mayssa Hachem   BIOCHIMIE

Post-acute COVID-19 syndrome

(2021) Ani Nalbandian et al.   NATURE MEDICINE

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

(2020) Charles E. Evans et al.   ACTA NEUROPATHOLOGICA

Emergence and Developmental Roles of the Cerebrospinal Fluid System

(2020) Ryann M. Fame et al.   DEVELOPMENTAL CELL

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage

(2020) Pengyu Pan et al.   Journal of Neuroinflammation

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice

(2020) Angustias Page et al.   International Journal of Oral Science

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

(2020) Bethany A. O’Hara et al.   PLoS Pathogens

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

CNS fluid and solute movement: physiology, modelling and imaging

(2020) Hazel C. Jones et al.   Fluids and Barriers of the CNS

SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection

(2020) Rafal Butowt et al.   ACS Chemical Neuroscience

Neurological Insights of COVID-19 Pandemic

(2020) Gaurav Das et al.   ACS Chemical Neuroscience

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

(2020) Abdul Mannan Baig et al.   ACS Chemical Neuroscience

SARS-CoV-2 Detected in Cerebrospinal Fluid by PCR in a Case of COVID-19 Encephalitis

(2020) Y. Hanna Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

The ACE-2 in COVID-19: Foe or Friend?

(2020) Rinkoo Dalan et al.   HORMONE AND METABOLIC RESEARCH

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China

(2020) Mingkai Tan et al.   IMMUNOLOGY

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

(2020) Chi Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A first case of meningitis/encephalitis associated with SARS-Coronavirus-2

(2020) Takeshi Moriguchi et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection

(2020) Giacomo Spinato et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

COVID‐19 diagnosis and management: a comprehensive review

(2020) Giuseppe Pascarella et al.   JOURNAL OF INTERNAL MEDICINE

Update on the neurology of COVID‐19

(2020) Josef Finsterer et al.   JOURNAL OF MEDICAL VIROLOGY

CD‐sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID‐19)

(2020) Pengfei Sun et al.   JOURNAL OF MEDICAL VIROLOGY

Stroke and mechanical thrombectomy in patients with COVID-19: technical observations and patient characteristics

(2020) Arthur Wang et al.   Journal of NeuroInterventional Surgery

Thromboinflammation and the hypercoagulability of COVID‐19

(2020) Jean M. Connors et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Kawasaki-like disease: emerging complication during the COVID-19 pandemic

(2020) Russell M Viner et al.   LANCET

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk

(2020) Nadine Kabbani et al.   MOLECULAR PHARMACOLOGY

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

(2020) Kangpeng Xiao et al.   NATURE

COVID-19: A primer for Neuroradiologists

(2020) Kshitij Mankad et al.   NEURORADIOLOGY

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

(2020) Thomas J. Oxley et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS2-CoV-2 and Stroke in a New York Healthcare System

(2020) Shadi Yaghi et al.   STROKE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier

(2020) Jihye Kim et al.   PLoS Pathogens

Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia

(2020) Letterio S. Politi et al.   JAMA Neurology

COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke

(2020) P. Belani et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19

(2020) Fang Liu et al.   JOURNAL OF CLINICAL VIROLOGY

Early evidence of pronounced brain involvement in fatal COVID-19 outcomes

(2020) Claus Hann von Weyhern et al.   LANCET

Estimates of the severity of coronavirus disease 2019: a model-based analysis

(2020) Robert Verity et al.   LANCET INFECTIOUS DISEASES

Neurological associations of COVID-19

(2020) Mark A Ellul et al.   LANCET NEUROLOGY

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

(2020) Yanwei Li et al.   PHARMACOLOGICAL RESEARCH

Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?

(2020) Fabio Perrotta et al.   RESPIRATORY MEDICINE

Emergent Large Vessel Occlusion Stroke During New York City’s COVID-19 Outbreak

(2020) Shahram Majidi et al.   STROKE

Cellular Senescence: Mechanisms, Morphology, and Mouse Models

(2020) Jessica Beck et al.   VETERINARY PATHOLOGY

Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza

(2020) Alexander E. Merkler et al.   JAMA Neurology

Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study

(2020) Yanan Li et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020

(2020) Mark W. Tenforde et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

(2020) Laura Pellegrini et al.   Cell Stem Cell

SARS ‐CoV‐2 targets neurons of 3D human brain organoids

(2020) Anand Ramani et al.   EMBO JOURNAL

Spike mutation D614G alters SARS-CoV-2 fitness

(2020) Jessica A. Plante et al.   NATURE

Health Behavior Changes During COVID-19 Pandemic and Subsequent “Stay-at-Home” Orders

(2020) Gregory Knell et al.   International Journal of Environmental Research and Public Health

Monocyte activation in systemic Covid-19 infection: Assay and rationale

(2020) Fernando O. Martinez et al.   EBioMedicine

Prolonged and late-onset symptoms of coronavirus disease 2019

(2020) Yusuke Miyazato et al.   Open Forum Infectious Diseases

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

(2020) Erik Volz et al.   CELL

Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer

(2020) Victoria A. Avanzato et al.   CELL

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

(2020) Jenny Meinhardt et al.   NATURE NEUROSCIENCE

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

(2020) Elizabeth M. Rhea et al.   NATURE NEUROSCIENCE

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

(2020) Tetyana P. Buzhdygan et al.   NEUROBIOLOGY OF DISEASE

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

(2020) Carlos Salama et al.   NEW ENGLAND JOURNAL OF MEDICINE

Psychological Symptoms and Behavioral Changes in Children and Adolescents During the Early Phase of COVID-19 Quarantine in Three European Countries

(2020) Rita Francisco et al.   Frontiers in Psychiatry

Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging

(2020) Molly Brady et al.   Fluids and Barriers of the CNS

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

(2019) Michelle Erickson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A high-fat diet induces rapid changes in the mouse hypothalamic proteome

(2019) Fiona H. McLean et al.   Nutrition & Metabolism

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis for human coronavirus attachment to sialic acid receptors

(2019) M. Alejandra Tortorici et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

(2019) Marc Desforges et al.   Viruses-Basel

The functional network signature of heterogeneity in freezing of gait

(2018) Kaylena A Ehgoetz Martens et al.   BRAIN

A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension

(2018) Anna R. Hemnes et al.   EUROPEAN RESPIRATORY JOURNAL

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

(2018) Michelle A. Erickson et al.   PHARMACOLOGICAL REVIEWS

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

(2018) Marta B. Wysocka et al.   Frontiers in Physiology

Monocytes and Macrophages as Viral Targets and Reservoirs

(2018) Ekaterina Nikitina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender

(2018) Qi Zhang et al.   MEDICINE

ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models

(2018) Natalia Alenina et al.   NEUROCHEMICAL RESEARCH

The role of the blood-brain barrier in hypertension

(2017) Anthony Setiadi et al.   EXPERIMENTAL PHYSIOLOGY

The Role of Neurogenic Inflammation in Blood-Brain Barrier Disruption and Development of Cerebral Oedema Following Acute Central Nervous System (CNS) Injury

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurological Complications during Treatment of Middle East Respiratory Syndrome

(2017) Jee-Eun Kim et al.   Journal of Clinical Neurology

Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition

(2017) Marina Bogush et al.   Journal of Neuroimmune Pharmacology

Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2

(2017) Jaqueline S. da Silva et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

The patient's perspective: The effect of levodopa on Parkinson symptoms

(2017) Heidemarie Zach et al.   PARKINSONISM & RELATED DISORDERS

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

A Role for Neutrophils in Viral Respiratory Disease

(2017) Jeremy V. Camp et al.   Frontiers in Immunology

CD14+CD16+ monocytes are the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua

(2017) Daniela Michlmayr et al.   Nature Microbiology

The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat

(2017) Scott E. Kanoski et al.   JOURNAL OF ALZHEIMERS DISEASE

High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia

(2016) Caroline Baufeld et al.   ACTA NEUROPATHOLOGICA

Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells

(2016) Janne Tynell et al.   JOURNAL OF GENERAL VIROLOGY

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

Human Coronavirus OC43 Associated with Fatal Encephalitis

(2016) Sofia Morfopoulou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple neural circuits mediating airway sensations: Recent advances in the neurobiology of the urge-to-cough

(2016) Alexandria K. Driessen et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The Intrarenal Renin-Angiotensin System in Hypertension

(2015) Robert M. Carey   ADVANCES IN CHRONIC KIDNEY DISEASE

The blood-brain barrier in neuroimmunology: Tales of separation and assimilation

(2015) W.A. Banks   BRAIN BEHAVIOR AND IMMUNITY

Peptides and the blood–brain barrier

(2015) William A. Banks   PEPTIDES

Development of the choroid plexus and blood-CSF barrier

(2015) Shane A. Liddelow   Frontiers in Neuroscience

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Increased CD147 (EMMPRIN) expression in the rat brain following traumatic brain injury

(2014) Ming Wei et al.   BRAIN RESEARCH

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

(2014) Hisham Qosa et al.   NEUROPHARMACOLOGY

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension

(2014) Quynh N. Dinh et al.   Biomed Research International

Multiple Functions of Angiotensin-Converting Enzyme 2 and Its Relevance in Cardiovascular Diseases

(2013) Keiji Kuba et al.   CIRCULATION JOURNAL

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

(2013) Joshua P. Thaler et al.   DIABETES

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

(2013) S. K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ACE2 alterations in kidney disease

(2013) M. J. Soler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

(2013) Itender Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview and introduction: The blood-brain barrier in health and disease

(2012) N. Joan Abbott et al.   EPILEPSIA

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Influenza Virus A Infection of Human Monocyte and Macrophage Subpopulations Reveals Increased Susceptibility Associated with Cell Differentiation

(2012) Marieke A. Hoeve et al.   PLoS One

Neutrophil in viral infections, friend or foe?

(2012) Brandon Drescher et al.   VIRUS RESEARCH

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia in the aging brain: relevance to neurodegeneration

(2010) Xiao-Guang Luo et al.   Molecular Neurodegeneration

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Endothelial Protein C Receptor-Assisted Transport of Activated Protein C across the Mouse Blood—Brain Barrier

(2008) Rashid Deane et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Innate immune response to viral infection of the lungs

(2008) Hayley See et al.   Paediatric Respiratory Reviews

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA