Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition

Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype

(2017) Shorena Janelidze et al.   NEUROBIOLOGY OF AGING

The quantification of blood-brain barrier disruption using dynamic contrast-enhanced magnetic resonance imaging in aging rhesus monkeys with spontaneous type 2 diabetes mellitus

(2017) Ziqian Xu et al.   NEUROIMAGE

Vascular complications in diabetes: Microparticles and microparticle associated microRNAs as active players

(2016) Nicoleta Alexandru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus

(2016) Dae Young YOO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

(2016) Andreea Iren Serban et al.   PLoS One

High Dietary Fructose Intake on Cardiovascular Disease Related Parameters in Growing Rats

(2016) SooYeon Yoo et al.   Nutrients

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration

(2015) Cheng-Hung Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Type 1 diabetes exacerbates blood-brain barrier alterations during experimental epileptic seizures in an animal model

(2015) Hatice Yorulmaz et al.   CELL BIOCHEMISTRY AND FUNCTION

From Pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy

(2015) Joseph F. Arboleda-Velasquez et al.   Current Diabetes Reports

Dysfunction of brain pericytes in chronic neuroinflammation

(2015) Yuri Persidsky et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diabetic Microangiopathy: Impact of Impaired Cerebral Vasoreactivity and Delayed Angiogenesis After Permanent Middle Cerebral Artery Occlusion on Stroke Damage and Cerebral Repair in Mice

(2014) Marine Poittevin et al.   DIABETES

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

(2013) Gul N. Shah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Connexin43 mediates NF-κB signalling activation induced by high glucose in GMCs: involvement of c-Src

(2013) Xi Xie et al.   Cell Communication and Signaling

Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β

(2013) B. Shao et al.   DIABETES OBESITY & METABOLISM

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Advanced glycation end-products disrupt the blood–brain barrier by stimulating the release of transforming growth factor–β by pericytes and vascular endothelial growth factor and matrix metalloproteinase–2 by endothelial cells in vitro

(2013) Fumitaka Shimizu et al.   NEUROBIOLOGY OF AGING

Cerebral Neovascularization and Remodeling Patterns in Two Different Models of Type 2 Diabetes

(2013) Roshini Prakash et al.   PLoS One

Reduced Expression of Prostacyclin Synthase and Nitric Oxide Synthase in Subcutaneous Arteries of Type 2 Diabetic Patients

(2013) Siti Safiah Mokhtar et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Oxidative stress in diabetes – circulating advanced glycation end products, lipid oxidation and vascular disease

(2013) Irundika HK Dias et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Human pericyte–endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment

(2012) Sonia Tarallo et al.   ACTA DIABETOLOGICA

Peroxisome Proliferator-Activated Receptor-γ Activation With Angiotensin II Type 1 Receptor Blockade Is Pivotal for the Prevention of Blood-Brain Barrier Impairment and Cognitive Decline in Type 2 Diabetic Mice

(2012) Li-Juan Min et al.   HYPERTENSION

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

(2012) Terry L. Davidson et al.   PHYSIOLOGY & BEHAVIOR

The emerging challenge in diabetes: The “metabolic memory”

(2012) Antonio Ceriello   VASCULAR PHARMACOLOGY

Neurovascular Coupling in Cognitive Impairment Associated With Diabetes Mellitus

(2011) Masaki Mogi et al.   CIRCULATION JOURNAL

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes

(2011) J. Wang et al.   NEUROSCIENCE

Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Streptozotocin-Induced Diabetic Rats

(2011) Kunjan R. Dave et al.   STROKE

Hyperglycaemia and Diabetes Impair Gap Junctional Communication among Astrocytes

(2010) Gautam K Gandhi et al.   ASN Neuro

P-glycoprotein and breast cancer resistance protein expression and function at the blood–brain barrier and blood–cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats

(2010) Valeska Reichel et al.   BRAIN RESEARCH

Vascular endothelial growth factors and vascular permeability

(2010) D. O. Bates   CARDIOVASCULAR RESEARCH

High Glucose Increases Lysyl Oxidase Expression and Activity in Retinal Endothelial Cells: Mechanism for Compromised Extracellular Matrix Barrier Function

(2010) A. Chronopoulos et al.   DIABETES

Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat

(2010) V.A. DiNapoli et al.   NEUROSCIENCE

Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier hyperpermeability

(2009) C. L. Allen et al.   DIABETES OBESITY & METABOLISM

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease

(2008) F. Peng et al.   DIABETES

Divergent effects of hyper- and hypoglycemia on circulating vascular endothelial growth factor in humans

(2007) Kerstin M. Oltmanns et al.   METABOLISM-CLINICAL AND EXPERIMENTAL