The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS

Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway

(2020) Chen Luo et al.   APOPTOSIS

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

(2020) Jinyun Dong et al.   DRUG RESISTANCE UPDATES

Analysis of global commonly-used phthalates and non-dietary exposure assessment in indoor environment

(2020) Subei Bu et al.   BUILDING AND ENVIRONMENT

Maternal exposure to Di-(2-ethylhexyl) phthalate (DEHP) activates the PI3K/Akt/mTOR signaling pathway in F1 and F2 generation adult mouse testis

(2020) Jie Zhang et al.   EXPERIMENTAL CELL RESEARCH

Taurine protects INS-1 cells from apoptosis induced by Di(2-ethylhexyl) phthalate via reducing oxidative stress and autophagy

(2019) Jianing Li et al.   TOXICOLOGY MECHANISMS AND METHODS

Reduced camptothecin sensitivity of estrogen receptor‐positive human breast cancer cells following exposure to di(2‐ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes

(2019) Chon‐Kit Chou et al.   ENVIRONMENTAL TOXICOLOGY

Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells

(2019) Yongjun Li et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Reactive oxygen species and cancer: A complex interaction

(2019) Sankaralingam Saikolappan et al.   CANCER LETTERS

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

(2019) Anastasiya V. Snezhkina et al.   Oxidative Medicine and Cellular Longevity

CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC

(2019) Wangta Liu et al.   Molecular Therapy-Nucleic Acids

Oxidative Stress and Reprogramming of Mitochondrial Function and Dynamics as Targets to Modulate Cancer Cell Behavior and Chemoresistance

(2019) Stefano Falone et al.   Oxidative Medicine and Cellular Longevity

Simultaneous determination of di(2-ethylhexyl) phthalate and diisononylcyclohexane-1,2-dicarboxylate and their monoester metabolites in four labile blood products by liquid chromatography tandem mass spectrometry

(2019) Amandine Descat et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis

(2018) Karthik M. Kodigepalli et al.   CELL CYCLE

Phthalates contamination in China: Status, trends and human exposure-with an emphasis on oral intake

(2018) Wei Wang et al.   ENVIRONMENTAL POLLUTION

Rifampicin Prevents SH-SY5Y Cells from Rotenone-Induced Apoptosis via the PI3K/Akt/GSK-3β/CREB Signaling Pathway

(2018) Xia Wu et al.   NEUROCHEMICAL RESEARCH

Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore

(2018) Saranya NavaneethaKrishnan et al.   ONCOGENE

The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment

(2018) Hanjiao Qin et al.   PeerJ

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells

(2018) Wei Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ferulic acid reverses P-glycoprotein-mediated multidrug resistance via inhibition of PI3K/Akt/NF-κB signaling pathway

(2018) Ganesan Muthusamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells

(2017) Hsin-Pao Chen et al.   Oncotarget

Effects of the P-glycoprotein (Pgp) antagonist tariquidar (XR-9576; TQD) on Pgp function as well as the toxicity and efficacy of combined chemotherapy in patients with metastatic adrenocortical cancer (mACC)

(2017) M. E. Menefee et al.   JOURNAL OF CLINICAL ONCOLOGY

Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal

(2017) Jung-Wei Chang et al.   Scientific Reports

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

(2016) Aparajitha Vaidyanathan et al.   BRITISH JOURNAL OF CANCER

Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma

(2016) Marilù Fanelli et al.   CURRENT CANCER DRUG TARGETS

Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies

(2016) Wen Li et al.   DRUG RESISTANCE UPDATES

Promotion of breast cancer cells MDA-MB-231 invasion by di(2-ethylhexyl)phthalate through matrix metalloproteinase-2/-9 overexpression

(2016) Shuya Zhang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway

(2016) Hong Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines

(2016) Nesstor Pilco-Ferreto et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Carcinogenetic mechanisms of endocrine disruptors in female cancers (Review)

(2016) Lino Del Pup et al.   ONCOLOGY REPORTS

Impact of low concentrations of phthalates on the effects of 17β-estradiol in MCF-7 breast cancer cells

(2016) Fang-Ping Chen et al.   Taiwanese Journal of Obstetrics & Gynecology

Pharmacokinetic and pharmacodynamic study of tariquidar (XR9576), a P-glycoprotein inhibitor, in combination with doxorubicin, vinorelbine, or docetaxel in children and adolescents with refractory solid tumors

(2015) Elizabeth Fox et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The role of ATP-binding cassette transporter genes in the progression of prostate cancer

(2015) Omer F. Karatas et al.   PROSTATE

In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach

(2015) Han Lin et al.   International Journal of Environmental Research and Public Health

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts

(2014) Ana C. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity

(2013) Pasquale Ventrice et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Activation of the PI3K–AKT–mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation

(2013) Xi Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Taiwan food scandal: The illegal use of phthalates as a clouding agent and their contribution to maternal exposure

(2013) Justin Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Intrinsic and Acquired Drug Resistance in Malignant Tumors

(2012) Theodor Lippert et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Phthalates in cosmetic and personal care products: Concentrations and possible dermal exposure

(2011) Diane Koniecki et al.   ENVIRONMENTAL RESEARCH

Phthalates induce proliferation and invasiveness of estrogen receptor-negative breast cancer through the AhR/HDAC6/c-Myc signaling pathway

(2011) Tsung-Hua Hsieh et al.   FASEB JOURNAL

Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds

(2011) P. Erkekoğlu et al.   FOOD AND CHEMICAL TOXICOLOGY

Experimental study on infusion devices containing polyvinyl chloride: To what extent are they di(2-ethylhexyl)phthalate-free?

(2011) Stéphanie Genay et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Goniothalamin Inhibits Growth of Human Lung Cancer Cells through DNA Damage, Apoptosis, and Reduced Migration Ability

(2011) Chien-Chih Chiu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells

(2011) Xing-Xiang Peng et al.   Chinese Journal of Cancer

The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Pavitra Kannan et al.   ACS Chemical Neuroscience

p38 MAPK and NF-κB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells

(2010) Chien-Chih Chiu et al.   CANCER LETTERS

A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

(2010) R. J. Kelly et al.   CLINICAL CANCER RESEARCH

Phthalates: Toxicogenomics and inferred human diseases

(2010) Sher Singh et al.   GENOMICS

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

A Phase I Study of the P-Glycoprotein Antagonist Tariquidar in Combination with Vinorelbine

(2009) J. Abraham et al.   CLINICAL CANCER RESEARCH

Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice

(2009) Erin R Gardner et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

Phosphoinositide 3-kinases in cell migration

(2008) Robert J. Cain et al.   BIOLOGY OF THE CELL

Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt

(2008) X Yang et al.   BRITISH JOURNAL OF CANCER

Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients

(2008) Suman Lal et al.   CANCER SCIENCE

Phthalates: metabolism and exposure

(2008) Matthias Wittassek et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE

Phthalates and Children’s Health

(2008) Sheela Sathyanarayana   Current Problems in Pediatric and Adolescent Health Care