SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis

A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature

(2018) Changhoon Oh et al.   Scientific Reports

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1

(2017) Nikolas Herold et al.   EXPERIMENTAL HEMATOLOGY

MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients

(2017) Rebecca Kohnken et al.   LEUKEMIA RESEARCH

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

(2017) Nikolas Herold et al.   NATURE MEDICINE

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

(2017) Waaqo Daddacha et al.   Cell Reports

Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells

(2016) Karthik M. Kodigepalli et al.   CELL CYCLE

The non-canonical functions of p27Kip1in normal and tumor biology

(2016) Savitha S. Sharma et al.   CELL CYCLE

A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability

(2016) Corine St. Gelais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

(2016) Constanze Schneider et al.   NATURE MEDICINE

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML

(2016) O Lindblad et al.   ONCOGENE

Heterozygous colon cancer-associated mutations ofSAMHD1have functional significance

(2016) Matilda Rentoft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells

(2016) Serena Bonifati et al.   VIROLOGY

Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection

(2016) Feifei Wang et al.   VIROLOGY

An update of current treatments for adult acute myeloid leukemia

(2015) H. Dombret et al.   BLOOD

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

(2015) Rebecca Kohnken et al.   Molecular Cancer

Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation

(2015) D Zhao et al.   ONCOGENE

PI3K/AKT pathway-mediated regulation of p27Kip1 is associated with cell cycle arrest and apoptosis in cervical cancer

(2015) Shyam Babu Prasad et al.   CELLULAR ONCOLOGY

SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation

(2014) Jia-lei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How I treat the older patient with acute myeloid leukemia

(2014) G. Ossenkoppele et al.   BLOOD

p27 and Leukemia: Cell Cycle and Beyond

(2014) Anita Roy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage

(2013) R. Clifford et al.   BLOOD

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

(2013) Dan A. Landau et al.   CELL

Promoter Methylation RegulatesSAMHD1Gene Expression in Human CD4+T Cells

(2013) Suresh de Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of SAMHD1 Expression Correlates with Promoter DNA Methylation in Sézary Syndrome Patients

(2013) Suresh de Silva et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

(2012) A. Schuh et al.   BLOOD

SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway

(2012) Xuqi Li et al.   CANCER LETTERS

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

(2012) J. Liu et al.   GENOME RESEARCH

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prognostic Significance of Cytoplasmic p27 Expression in Human Melanoma

(2011) G. Chen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling

(2011) Ming Ma et al.   CANCER LETTERS

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia

(2009) S. Park et al.   HAEMATOLOGICA

In Vivo Bioluminescence Imaging of Murine Xenograft Cancer Models with a Red-shifted Thermostable Luciferase

(2009) Laura Mezzanotte et al.   MOLECULAR IMAGING AND BIOLOGY

Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry

(2008) G. Juliusson et al.   BLOOD

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE