Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Multidisciplinary Sciences
Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis
Summary: Serine/one-carbon metabolism plays a critical role in cancer cell growth, but the regulatory mechanisms are not well understood. This study reveals that glycogen synthase kinase 3 (GSK3) plays a key role in regulating the expression of serine/one-carbon metabolic enzymes. Inhibition of nuclear GSK3 signaling enhances the efficacy of serine/one-carbon metabolism inhibitors in suppressing cancer cell proliferation.
Article
Plant Sciences
Satoshi Okuyama, Yoshiko Furukawa, Morio Yoshimura, Yoshiaki Amakura, Mitsunari Nakajima, Takashi Yoshida
Summary: The study results showed that Oenothein B can reduce brain inflammation and enhance neuronal signaling pathways, thus exerting neuroprotective effects on the central nervous system.
Article
Biochemistry & Molecular Biology
Xin Su, Wenbin Wang, Siyang Ma, Huahan Ning, Jiaxi Chen
Summary: This experiment aimed to analyze the effects of modulating miR-7 on rats with colorectal cancer complicated with HP infection and its influence on the Akt/GSK-3β/β-catenin pathway. The results showed that modulation of miR-7 improved the inflammatory condition and alleviated HP infection in rats, playing a positive role in intervention.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Neurosciences
Anil Kumar Rana, Supriya Sharma, Vikram Patial, Damanpreet Singh
Summary: Estrogen deprivation during menopause leads to changes in brain neuronal circuit and neurobehavioral symptoms later in life. Hormone replacement therapy can partially alleviate these abnormalities but is associated with various adverse effects. This study investigated the effect of lithium therapy on neurobehavioral impairments in a rat model of ovariectomy, which mimics postmenopausal conditions. The results showed that lithium treatment protected against spatial and recognition memory impairments, as well as depression-like behavior in ovariectomized rats. Additionally, lithium treatment increased dendritic length and spine density in certain brain regions, reduced proinflammatory markers, normalized reactive astrogliosis, and modulated key signaling pathways. These findings suggest that lithium may be a potential therapeutic agent for managing postmenopausal neurological symptoms.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Divya M. Teli, Anuradha K. Gajjar
Summary: Elevated glucose level due to β-cell dysfunction is a key marker of Type-II diabetes. GSK-3, an enzyme involved in glycogen metabolism control, has been explored for its potential as a target for diabetes treatment. This review article examines the structural analysis and molecular modeling of GSK-3, as well as advancements in the development of GSK-3 inhibitors as potential therapeutics for Type II diabetes.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Shu-Sheng Yang, He-Yuan Shi, Peng Zeng, Jing Xia, Ping Wang, Li Lin
Summary: The study investigated the neuroprotective effects and improvement of learning/memory capacity by BSHTYZ in rat AD models induced by Aβ(1-42) through the GSK-3 beta / CREB signaling pathway. Results showed that BSHTYZ reversed the spatial learning and memory impairments induced by Aβ(1-42) and modulated relevant molecular interplays, suggesting its potential therapeutic role in delaying the progression of AD.
Article
Biochemistry & Molecular Biology
Katharina Jans, Kai Luersen, Jakob von Frieling, Thomas Roeder, Gerald Rimbach
Summary: A study found that dietary lithium can significantly improve fruit fly egg production by regulating the mRNA levels of genes related to follicular maturation. This is the first report of dietary lithium acting as a stimulant for fecundity in fruit flies.
Article
Biochemistry & Molecular Biology
Melissa Guardigni, Letizia Pruccoli, Alan Santini, Angela De Simone, Matteo Bersani, Francesca Spyrakis, Flavia Frabetti, Elisa Uliassi, Vincenza Andrisano, Barbara Pagliarani, Paula Fernandez-Gomez, Valle Palomo, Maria Laura Bolognesi, Andrea Tarozzi, Andrea Milelli
Summary: A small set of novel GSK-3β degraders were designed and synthesized using PROTAC technology. Compound 1 emerged as the most effective PROTAC, being nontoxic to neuronal cells and able to degrade GSK-3β in a dose-dependent manner. PROTAC 1 significantly reduced neurotoxicity induced by Aβ25-35 peptide and CuSO4.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Izabela Gutowska, Agnieszka Maruszewska, Marta Skorka-Majewicz, Agnieszka Kempinska-Podhorodecka, Agnieszka Kolasa, Agata Wszolek, Irena Baranowska-Bosiacka, Wojciech Zwierello
Summary: Human exposure to fluorine from multiple sources can lead to metabolic disorders, particularly in muscle cells. This study investigated the impact of fluoride exposure on enzymes involved in muscle glycogen metabolism. It was found that fluoride exposure altered energy state, enzyme expression, and glycogen deposition in cells.
Review
Biochemistry & Molecular Biology
Margaux Sambon, Pierre Wins, Lucien Bettendorff
Summary: Thiamine thioesters, such as benfotiamine (BFT) and dibenzoylthiamine (DBT), have shown potential benefits in treating neurodegenerative diseases with antioxidant and anti-inflammatory properties. Recent studies suggest that DBT may be even more efficient than BFT in terms of anti-inflammatory potency. These thiamine thioesters have pleiotropic properties and may lead to promising advancements in neurodegenerative, neurodevelopmental, and psychiatric conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xinjiang Cai, Yan Zhao, Yang Yang, Xiuju Wu, Li Zhang, Jocelyn A. Ma, Jaden Ji, Kristina I. Bostrom, Yucheng Yao
Summary: Glycogen synthase kinase-3 beta (GSK3 beta) inhibition or endothelial-specific deletion of GSK3 beta reduces atherosclerotic calcification. The changes in beta-catenin and SMAD1 induced by GSK3 beta inhibition in the aortas of Apoe(-/-) mice are similar to Mgp(-/-) mice. This suggests that GSK3 beta inhibition reduces vascular calcification in atherosclerotic lesions through a similar mechanism to that in Mgp(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Samuel M. Law, Jie J. Zheng
Summary: Wnt signaling pathways play a significant role in various diseases. β-catenin is central to the canonical Wnt signaling pathway. CHIR-99021, a GSK-3β inhibitor, is widely used for studying this pathway. However, caution is needed when using CHIR-99021 at certain concentrations.
Article
Cell Biology
Lei Sun, He Yang, Dong He, Jian Chen, Zhiqiang Dong, Shaoxiang Luo, Huiting Liang, Yu Cao, Bingcheng Cai, Min Zhang
Summary: This study identifies a mammalian eIF4E2-GSK3 beta pathway that prevents senescence by maintaining basal phosphorylation of p53, providing a theoretical basis for hypoxia adaptation of tissues.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Chenggang Zhao, Huihan Yu, Xiaoqing Fan, Wanxiang Niu, Junqi Fan, Suling Sun, Meiting Gong, Bing Zhao, Zhiyou Fang, Xueran Chen
Summary: This study revealed the role of GSK3β in temozolomide resistance in GBM, showing that palmitoylation mediated by ZDHHC4 enhances stemness and activates the EZH2-STAT3 pathway.
