The Gasotransmitter Hydrogen Sulfide (H2S) Prevents Pathologic Calcification (PC) in Cartilage

Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort

(2020) Amy B. Karger et al.   Journal of the American Heart Association

Pathological calcification in osteoarthritis: an outcome or a disease initiator?

(2020) Jian-fei Yan et al.   BIOLOGICAL REVIEWS

Cartilage calcification and osteoarthritis: a pathological association?

(2020) J. Stack et al.   OSTEOARTHRITIS AND CARTILAGE

Hydrogen sulfide abrogates heart valve calcification: Implications for calcific aortic valve disease

(2019) Katalin Éva Sikura et al.   BRITISH JOURNAL OF PHARMACOLOGY

Short-Term Preoperative Protein Restriction Attenuates Vein Graft Disease via Induction of Cystathionine ϒ-Lyase

(2019) Kaspar M Trocha et al.   CARDIOVASCULAR RESEARCH

The role of the gasotransmitter hydrogen sulfide in pathological calcification

(2019) Mariela Castelblanco et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chondrocalcinosis is associated with increased knee joint degeneration over 4 years: data from the Osteoarthritis Initiative

(2019) S.C. Foreman et al.   OSTEOARTHRITIS AND CARTILAGE

Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

(2018) Ching-Hou Ma et al.   Redox Biology

Calcium crystal deposition diseases — beyond gout

(2018) Geraldine M. McCarthy et al.   Nature Reviews Rheumatology

The biologic effect of hydrogen sulfide and its function in various diseases

(2018) Qing Xiao et al.   MEDICINE

Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways

(2018) Laure Campillo-Gimenez et al.   Frontiers in Immunology

International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H 2 S Levels: H 2 S Donors and H 2 S Biosynthesis Inhibitors

(2017) Csaba Szabo et al.   PHARMACOLOGICAL REVIEWS

Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin

(2017) Jyaysi Desai et al.   Scientific Reports

H2S-Induced Sulfhydration: Biological Function and Detection Methodology

(2017) Da Zhang et al.   Frontiers in Pharmacology

Evaluation of Salivary Cytokines for Diagnosis of both Trauma-Induced and Genetic Heterotopic Ossification

(2017) Hsiao Hsin Sung Hsieh et al.   Frontiers in Endocrinology

OP0287 Calcium Pyrophosphate Dihydrate Crystals Induce IL-1β Production by Monocytes through A Potassium Efflux-Dependent Pathway

(2016) L. Campillo-Gimenez et al.   ANNALS OF THE RHEUMATIC DISEASES

Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-α

(2016) Parisa Aghagolzadeh et al.   ATHEROSCLEROSIS

H2S biosynthesis and catabolism: new insights from molecular studies

(2016) Peter Rose et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

(2016) Liping Xie et al.   DIABETES

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

(2016) Shrikant R. Mulay et al.   Nature Communications

Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis

(2016) Sonia Nasi et al.   PLoS One

Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis

(2015) Sonia Nasi et al.   ANNALS OF THE RHEUMATIC DISEASES

Heterotopic Ossification

(2015) Kavitha Ranganathan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency

(2015) Francesco Grassi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

GYY4137 Promotes Bone Formation in a Rabbit Distraction Osteogenesis Model: A Preliminary Report

(2015) Xiaowen Jiang et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Physiologic Levels of Endogenous Hydrogen Sulfide Maintain the Proliferation and Differentiation Capacity of Periodontal Ligament Stem Cells

(2015) Yingying Su et al.   JOURNAL OF PERIODONTOLOGY

Toward a Selective, Sensitive, Fast-Responsive, and Biocompatible Two-Photon Probe for Hydrogen Sulfide in Live Cells

(2014) Subhankar Singha et al.   ANALYTICAL CHEMISTRY

Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration

(2014) Yi Liu et al.   Cell Stem Cell

Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway

(2014) Cheng Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis

(2014) Sonia Nasi et al.   JOINT BONE SPINE

Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes

(2014) E.F. Burguera et al.   OSTEOARTHRITIS AND CARTILAGE

Pathogenic Role of Basic Calcium Phosphate Crystals in Destructive Arthropathies

(2013) Hang-Korng Ea et al.   PLoS One

Disulfide bonds are critical for tissue-nonspecific alkaline phosphatase function revealed by analysis of mutant proteins bearing a C201-Y or C489-S substitution associated with severe hypophosphatasia

(2012) Yasuhito Satou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells

(2011) Erzsébet Zavaczki et al.   KIDNEY INTERNATIONAL

Cystathionine γ-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury

(2010) Isao Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1β-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2

(2010) B. Kloesch et al.   RHEUMATOLOGY INTERNATIONAL

Calcification of articular cartilage in human osteoarthritis

(2009) M. Fuerst et al.   ARTHRITIS AND RHEUMATISM

Bone tissue and hyperhomocysteinemia

(2009) Régis Levasseur   JOINT BONE SPINE

Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts

(2009) Tzu-Hung Lin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis

(2009) Y.Z. Liu et al.   OSTEOARTHRITIS AND CARTILAGE

Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals

(2008) H K Ea et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of homocysteine in aortic calcification and osteogenic cell differentiation

(2008) Ann Van Campenhout et al.   ATHEROSCLEROSIS

Mouse models of cystathionine β-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia

(2008) Sapna Gupta et al.   FASEB JOURNAL

Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia

(2008) Noriyuki Akahoshi et al.   HUMAN MOLECULAR GENETICS

Sodium thiosulfate prevents vascular calcifications in uremic rats

(2008) Andreas Pasch et al.   KIDNEY INTERNATIONAL

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE