To Be, or Notch to Be: Mediating Cell Fate from Embryogenesis to Lymphopoiesis

CADASIL from Bench to Bedside: Disease Models and Novel Therapeutic Approaches

(2021) Arianna Manini et al.   MOLECULAR NEUROBIOLOGY

Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors

(2021) Vignesh Shanmugam et al.   Blood Advances

Notch2-mediated plasticity between marginal zone and follicular B cells

(2021) Markus Lechner et al.   Nature Communications

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium

(2020) Alicja Kamińska et al.   Reproductive Biology and Endocrinology

Clinical and Genetic Aspects of CADASIL

(2020) Toshiki Mizuno et al.   Frontiers in Aging Neuroscience

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells

(2020) Ankita Mitra et al.   Frontiers in Immunology

Endothelial Jagged1 Antagonizes Dll4/Notch Signaling in Decidual Angiogenesis during Early Mouse Pregnancy

(2020) Nicole M. Marchetto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response

(2020) Maria Valeria Giuli et al.   Oncogenesis

Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model

(2020) Han Leng Ng et al.   MOLECULAR IMMUNOLOGY

Targeting Notch in oncology: the path forward

(2020) Samarpan Majumder et al.   NATURE REVIEWS DRUG DISCOVERY

Cis-activation in the Notch signaling pathway

(2019) Nagarajan Nandagopal et al.   eLife

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques

(2019) Jelena Petrovic et al.   MOLECULAR CELL

Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL

(2019) Luca Tottone et al.   Frontiers in Oncology

Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture

(2019) Victor A. Negri et al.   Scientific Reports

Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype

(2019) M. V. Giuli et al.   Journal of Oncology

Notch after cleavage

(2018) Sarah J Bray et al.   CURRENT OPINION IN CELL BIOLOGY

Systematic Review

(2018) B.M. Kamath et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells

(2018) Marica Pinazza et al.   ONCOGENE

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

(2018) Aled J. Parry et al.   Nature Communications

Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?

(2018) Venus Sosa Iglesias et al.   Frontiers in Oncology

IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation

(2018) Filomena De Falco et al.   Cell Death & Disease

Clinical and diagnostic relevance of NOTCH2 -and KLF2 -mutations in splenic marginal zone lymphoma

(2017) Yolanda Campos-Martín et al.   HAEMATOLOGICA

Both Notch1 and its ligands in B cells promote antibody production

(2017) Gaizhi Zhu et al.   MOLECULAR IMMUNOLOGY

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas

(2017) Russell J.H. Ryan et al.   Cell Reports

Clinical and diagnostic relevance of NOTCH2 -and KLF2 -mutations in splenic marginal zone lymphoma

(2017) Yolanda Campos-Martín et al.   HAEMATOLOGICA

Do as I say, Not(ch) as I do: Lateral control of cell fate

(2017) Marika Sjöqvist et al.   DEVELOPMENTAL BIOLOGY

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche

(2016) Michela Colombo et al.   Oncotarget

Transmission of survival signals through Delta-like 1 on activated CD4+ T cells

(2016) Takahiro Furukawa et al.   Scientific Reports

Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome

(2015) Josephina A.N. Meester et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart

(2015) Mélanie Metrich et al.   CARDIOVASCULAR RESEARCH

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

The Notch pathway in colorectal cancer

(2015) Kaitlyn E. Vinson et al.   INTERNATIONAL JOURNAL OF CANCER

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL

(2015) Filomena De Falco et al.   Oncotarget

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

Notching on Cancer’s Door: Notch Signaling in Brain Tumors

(2015) Marcin Teodorczyk et al.   Frontiers in Oncology

Mutations in NOTCH1 Cause Adams-Oliver Syndrome

(2014) Anna-Barbara Stittrich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Notch4 reveals a novel mechanism regulating Notch signal transduction

(2014) A.C. James et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection

(2014) L. Arcaini et al.   HAEMATOLOGICA

Hajdu-Cheney syndrome: a review

(2014) Ernesto Canalis et al.   Orphanet Journal of Rare Diseases

Long-range enhancer activity determinesMycsensitivity to Notch inhibitors in T cell leukemia

(2014) Yumi Yashiro-Ohtani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL

(2014) Maria Pelullo et al.   NEOPLASIA

RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome

(2012) Susan J. Hassed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The coding genome of splenic marginal zone lymphoma: activation ofNOTCH2and other pathways regulating marginal zone development

(2012) Davide Rossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent somaticNOTCH2mutations in splenic marginal zone lymphoma

(2012) Mark J. Kiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy

(2012) A H Nwabo Kamdje et al.   Blood Cancer Journal

Mechanism and Significance of cis-Inhibition in Notch Signalling

(2011) David del Álamo et al.   CURRENT BIOLOGY

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Serpentine fibula-polycystic kidney syndrome caused by truncating mutations in NOTCH2

(2011) Bertrand Isidor et al.   HUMAN MUTATION

NOTCH2mutations in Alagille syndrome

(2011) Binita Maya Kamath et al.   JOURNAL OF MEDICAL GENETICS

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

Notch1 signaling is mediated by importins alpha 3, 4, and 7

(2010) Kerstin Huenniger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

(2010) David Sprinzak et al.   NATURE

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch Ligands Expressed by Follicular Dendritic Cells Protect Germinal Center B Cells from Apoptosis

(2009) S.-O. Yoon et al.   JOURNAL OF IMMUNOLOGY

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis

(2008) D. B. Sparrow et al.   HUMAN MOLECULAR GENETICS

Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-Intrinsic Mechanisms

(2008) Thorsten B. Feyerabend et al.   IMMUNITY

Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development

(2008) Yin Sheng et al.   IMMUNOLOGY LETTERS

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

(2008) Jemima Cordle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY