The Notch pathway in colorectal cancer

The Role of Epigenetic Mechanisms in Notch Signaling During Development

(2015) Ralf Schwanbeck   JOURNAL OF CELLULAR PHYSIOLOGY

Molecular identification and targeting of colorectal cancer stem cells

(2015)   Oncotarget

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer

(2014) R. A. Previs et al.   CLINICAL CANCER RESEARCH

Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells

(2013) Ingrid Espinoza et al.   CANCER LETTERS

Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis

(2013) William K.K. Wu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Role of Notch signalling pathway in cancer and its association with DNA methylation

(2013) MADHURI G. S. AITHAL et al.   JOURNAL OF GENETICS

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Notch inhibitors for cancer treatment

(2013) Ingrid Espinoza et al.   PHARMACOLOGY & THERAPEUTICS

Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway

(2012) Klaus Geissler et al.   ANNALS OF HEMATOLOGY

Developmental signaling pathways in cancer stem cells of solid tumors

(2012) Christina Karamboulas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Developmental pathways in colon cancer

(2012) Fred E. Bertrand et al.   CELL CYCLE

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Colorectal Cancer Stem Cells

(2012) Aristides G. Vaiopoulos et al.   STEM CELLS

Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer

(2011) D. Chu et al.   ANNALS OF ONCOLOGY

Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

(2011) K Pandya et al.   BRITISH JOURNAL OF CANCER

The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways

(2011) Michael Bordonaro et al.   EXPERIMENTAL CELL RESEARCH

Wnt signaling and colon tumorigenesis — A view from the periphery

(2011) Antony W. Burgess et al.   EXPERIMENTAL CELL RESEARCH

Complex interplay between  -catenin signalling and Notch effectors in intestinal tumorigenesis

(2011) G. Peignon et al.   GUT

Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways

(2011) Shengkai Liao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phase I Trial of MK-0752 in Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study

(2011) Maryam Fouladi et al.   JOURNAL OF CLINICAL ONCOLOGY

Delta-Like Ligand 4 Regulates Central Nervous System T Cell Accumulation during Experimental Autoimmune Encephalomyelitis

(2011) N. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Colorectal cancer screening

(2011) M. Bretthauer   JOURNAL OF INTERNAL MEDICINE

Notch3 signalling promotes tumour growth in colorectal cancer

(2011) Valentina Serafin et al.   JOURNAL OF PATHOLOGY

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

(2011) Jan Paul Medema et al.   NATURE

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch1 regulates the growth of human colon cancers

(2010) Yan Zhang et al.   CANCER

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

(2010) S. S. Sikandar et al.   CANCER RESEARCH

The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

(2010) Zhiwei Wang et al.   CURRENT DRUG TARGETS

Notch Signaling Pathway as a Therapeutic Target in Breast Cancer

(2010) H. Al-Hussaini et al.   MOLECULAR CANCER THERAPEUTICS

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate

(2010) Georgios Kallifatidis et al.   MOLECULAR THERAPY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

(2009) J Tammam et al.   BRITISH JOURNAL OF PHARMACOLOGY

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promoter Methylation in the Genesis of Gastrointestinal Cancer

(2009) Clement Richard Boland et al.   YONSEI MEDICAL JOURNAL

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease

A Notch1 Ectodomain Construct Inhibits Endothelial Notch Signaling, Tumor Growth, and Angiogenesis

(2008) Y. Funahashi et al.   CANCER RESEARCH

Intracellular trafficking of Notch receptors and ligands

(2008) Christel Brou   EXPERIMENTAL CELL RESEARCH

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY