Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Applications of carbon nanotubes and polymeric micro‐/nanoparticles in fish vaccine delivery: progress and future perspectives

(2021) Sib Sankar Giri et al.   Reviews in Aquaculture

Covalent immobilization of trypsin on polyvinyl alcohol-coated magnetic nanoparticles activated with glutaraldehyde

(2020) Selmihan Sahin et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines

(2020) Mariusz Skwarczynski et al.   Science Advances

Polyacrylate–Peptide Antigen Conjugate as a Single-Dose Oral Vaccine against Group A Streptococcus

(2020) Mohammad Omer Faruck et al.   Vaccines

Synthetic high-density lipoprotein nanodiscs for personalized immunotherapy against gliomas

(2020) Lindsay Scheetz et al.   CLINICAL CANCER RESEARCH

Carbon nanotubes-loaded subunit vaccine can increase protective immunity against rhabdovirus infections of largemouth bass (Micropterus Salmoides)

(2020) Zi-Rao Guo et al.   FISH & SHELLFISH IMMUNOLOGY

Immune efficacy of carbon nanotubes recombinant subunit vaccine against largemouth bass ulcerative syndrome virus

(2020) Yi-Jun Jia et al.   FISH & SHELLFISH IMMUNOLOGY

Development of Polyelectrolyte Complexes for the Delivery of Peptide-Based Subunit Vaccines against Group A Streptococcus

(2020) Lili Zhao et al.   Nanomaterials

Better Adjuvants for Better Vaccines: Progress in Adjuvant Delivery Systems, Modifications, and Adjuvant–Antigen Codelivery

(2020) Zhi-Biao Wang et al.   Vaccines

Hollow Mesoporous Silica Nanoparticles with Extra-Large Mesopores for Enhanced Cancer Vaccine

(2020) Jun Yup Lee et al.   ACS Applied Materials & Interfaces

Controlling timing and location in vaccines

(2020) Darrell J. Irvine et al.   ADVANCED DRUG DELIVERY REVIEWS

Optimized Methods for the Production and Bioconjugation of Site-Specific, Alkyne-Modified Glucagon-like Peptide-1 (GLP-1) Analogs to Azide-Modified Delivery Platforms Using Copper-Catalyzed Alkyne–Azide Cycloaddition

(2020) Seyed Ebrahim Alavi et al.   BIOCONJUGATE CHEMISTRY

COVID-19 vaccine development and a potential nanomaterial path forward

(2020) Matthew D. Shin et al.   Nature Nanotechnology

Use of Veterinary Vaccines for Livestock as a Strategy to Control Foodborne Parasitic Diseases

(2020) Valeria A. Sander et al.   Frontiers in Cellular and Infection Microbiology

M-protein based vaccine induces immunogenicity and protection from Streptococcus pyogenes when delivered on a high-density microarray patch (HD-MAP)

(2020) Jamie-Lee S. Mills et al.   npj Vaccines

Mannose-Modified Chitosan-Nanoparticle-Based Salmonella Subunit OralVaccine-Induced Immune Response and Efficacy in a Challenge Trial in Broilers

(2020) Yi Han et al.   Vaccines

Biomedical and Pharmacological Uses of Fluorescein Isothiocyanate Chitosan‐Based Nanocarriers

(2020) Anna E. Caprifico et al.   MACROMOLECULAR BIOSCIENCE

Emerging Concepts and Technologies in Vaccine Development

(2020) Morgan Brisse et al.   Frontiers in Immunology

Carbohydrate Immune Adjuvants in Subunit Vaccines

(2020) Sahra Bashiri et al.   Pharmaceutics

Optimizing the immunization procedure of single-walled carbon nanotubes based vaccine against grass carp reovirus for grass carp

(2020) De-Kui Qiu et al.   AQUACULTURE

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Cell-penetrating Peptides: Efficient Vectors for Vaccine Delivery

(2019) Jieru Yang et al.   Current Drug Delivery

Targeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy

(2019) Linhua Zhang et al.   NANO LETTERS

Percutaneous immunization with 40-nm antigen-encapsulated elastic liposomes

(2019) Yuki Kakami et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Polymers for subunit vaccine delivery

(2019) Reshma J. Nevagi et al.   EUROPEAN POLYMER JOURNAL

Polymeric “Clickase” Accelerates the Copper Click Reaction of Small Molecules, Proteins, and Cells

(2019) Junfeng Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

(2019) Shuting Shi et al.   VACCINE

HBs antigen and mannose loading on the surface of iron oxide nanoparticles in order to immuno-targeting: fabrication, characterization, cellular and humoral immunoassay

(2019) Mahsa Rezaei et al.   Artificial Cells Nanomedicine and Biotechnology

Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone

(2019) Sang-Hyun Kim et al.   International Journal of Nanomedicine

Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity

(2019) Yi-Nan Zhang et al.   NANO LETTERS

Development of a Gold Nanoparticle Vaccine against Enterohemorrhagic Escherichia coli O157:H7

(2019) Javier I. Sanchez-Villamil et al.   mBio

Polyelectrolyte-Based Platforms for the Delivery of Peptides and Proteins

(2019) Lili Zhao et al.   ACS Biomaterials-Science & Engineering

Carbon nanotube-based DNA vaccine against koi herpesvirus given by intramuscular injection

(2019) Feng Hu et al.   FISH & SHELLFISH IMMUNOLOGY

Presentation of HIV-1 Envelope Trimers on the Surface of Silica Nanoparticles

(2019) Stefanie Thalhauser et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Gold nanoparticle‐adjuvanted S protein induces a strong antigen‐specific IgG response against severe acute respiratory syndrome‐related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs

(2019) Hanako Sekimukai et al.   MICROBIOLOGY AND IMMUNOLOGY

Direct quantification of surface coverage of antibody in IgG-Gold nanoparticles conjugates

(2019) Lu Zhang et al.   TALANTA

Galectin-1 protein modified gold (III)-PEGylated complex-nanoparticles: Proof of concept of alternative probe in colorimetric glucose detection

(2019) Qiqian Liu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of an immersion DNA vaccine against infectious spleen and kidney necrosis virus in mandarin fish

(2019) Zhao Zhao et al.   FISH & SHELLFISH IMMUNOLOGY

Early vaccine advocacy: Medals honoring Edward Jenner issued during the 19th century

(2019) José Esparza   VACCINE

Facile Fabrication of a Modular “Catch and Release” Hydrogel Interface: Harnessing Thiol–Disulfide Exchange for Reversible Protein Capture and Cell Attachment

(2018) Tugce Nihal Gevrek et al.   ACS Applied Materials & Interfaces

Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination

(2018) Rong Yang et al.   ACS Nano

Subcutaneous Nanodisc Vaccination with Neoantigens for Combination Cancer Immunotherapy

(2018) Rui Kuai et al.   BIOCONJUGATE CHEMISTRY

Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses

(2018) Medea Neek et al.   BIOMATERIALS

Phase I trial of Lipovaxin-MM, a novel dendritic cell-targeted liposomal vaccine for malignant melanoma

(2018) Tessa Gargett et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Nanovaccines formulation and applications-a review

(2018) Hemant K.S. Yadav et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Gold nanoparticles conjugating recombinant influenza hemagglutinin trimers and flagellin enhanced mucosal cellular immunity

(2018) Chao Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Evaluation of safety and immunogenicity of a group A streptococcus vaccine candidate (MJ8VAX) in a randomized clinical trial

(2018) Silvana Sekuloski et al.   PLoS One

Recent Advances in Vaccine Technologies

(2018) Michael James Francis   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments

(2018) Michelle K. Greene et al.   Chemical Science

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Elimination of established tumors with nanodisc-based combination chemoimmunotherapy

(2018) Rui Kuai et al.   Science Advances

Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems

(2018) M. Danaei et al.   Pharmaceutics

Achieving Controlled Biomolecule–Biomaterial Conjugation

(2018) Christopher D. Spicer et al.   CHEMICAL REVIEWS

Bioconjugation with Maleimides: A useful Tool for Chemical Biology

(2018) Pedro Miguel pimenta Gois et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nano based drug delivery systems: recent developments and future prospects

(2018) Jayanta Kumar Patra et al.   JOURNAL OF NANOBIOTECHNOLOGY

The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery

(2018) Matthias Bros et al.   Frontiers in Immunology

Comparative Analysis of Nanoparticle-Antibody Conjugations: Carbodiimide Versus Click Chemistry

(2018) Daniel L.J. Thorek et al.   Molecular Imaging

Lipids as activators of innate immunity in peptide vaccine delivery.

(2018) Stacey Bartlett et al.   CURRENT MEDICINAL CHEMISTRY

Protein-based nanoparticles in cancer vaccine development

(2018) Medea Neek et al.   Nanomedicine-Nanotechnology Biology and Medicine

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

(2018) Talar Tokatlian et al.   Scientific Reports

Nanoparticle Vaccines Against Infectious Diseases

(2018) Rashmirekha Pati et al.   Frontiers in Immunology

The application of self-assembled nanostructures in peptide-based subunit vaccine development

(2017) Guangzu Zhao et al.   EUROPEAN POLYMER JOURNAL

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Dual-linker gold nanoparticles as adjuvanting carriers for multivalent display of recombinant influenza hemagglutinin trimers and flagellin improve the immunological responses in vivo and in vitro

(2017) Chao Wang et al.   International Journal of Nanomedicine

Effects of gold nanoparticle-based vaccine size on lymph node delivery and cytotoxic T-lymphocyte responses

(2017) Sukmo Kang et al.   JOURNAL OF CONTROLLED RELEASE

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

(2017) Shridhar Bale et al.   JOURNAL OF VIROLOGY

Protein-protein conjugate nanoparticles for malaria antigen delivery and enhanced immunogenicity

(2017) Puthupparampil V. Scaria et al.   PLoS One

Copper-catalyzed click reaction on/in live cells

(2017) Siheng Li et al.   Chemical Science

Physicochemical characterisation, immunogenicity and protective efficacy of a lead streptococcal vaccine: progress towards Phase I trial

(2017) Manisha Pandey et al.   Scientific Reports

Noninvasive Transdermal Vaccination Using Hyaluronan Nanocarriers and Laser Adjuvant

(2016) Ki Su Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses

(2016) Nicholas M. Molino et al.   BIOMATERIALS

Multiantigenic peptide–polymer conjugates as therapeutic vaccines against cervical cancer

(2016) Waleed M. Hussein et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development and Applications of the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) as a Bioorthogonal Reaction

(2016) Li Li et al.   MOLECULES

Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles

(2016) Daniela S. Bernardi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying

(2016) Phillip M. Lovalenti et al.   PHARMACEUTICAL RESEARCH

A Method for Producing Protein Nanoparticles with Applications in Vaccines

(2016) David S. Jones et al.   PLoS One

Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines

(2016) Waleed M. Hussein et al.   Chemical Science

Peptide-based synthetic vaccines

(2016) Mariusz Skwarczynski et al.   Chemical Science

Current prospects and future challenges for nasal vaccine delivery

(2016) Helmy Yusuf et al.   Human Vaccines & Immunotherapeutics

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

(2016) Kyoji Tsuchikama et al.   Protein & Cell

Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides

(2016) Jan Dommerholt et al.   Topics in Current Chemistry

Engineered Human Ferritin Nanoparticles for Direct Delivery of Tumor Antigens to Lymph Node and Cancer Immunotherapy

(2016) Bo-Ram Lee et al.   Scientific Reports

Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications

(2015) Haipeng Liu et al.   BIOCONJUGATE CHEMISTRY

Conjugating influenza a (H1N1) antigen to n-trimethylaminoethylmethacrylate chitosan nanoparticles improves the immunogenicity of the antigen after nasal administration

(2015) Qingfeng Liu et al.   JOURNAL OF MEDICAL VIROLOGY

Monoclonal Antibody-Targeted Fluorescein-5-isothiocyanate-Labeled Biomimetic Nanoapatites: A Promising Fluorescent Probe for Imaging Applications

(2015) Francesca Oltolina et al.   LANGMUIR

Significance of surface charge and shell material of superparamagnetic iron oxide nanoparticle (SPION) based core/shell nanoparticles on the composition of the protein corona

(2015) Usawadee Sakulkhu et al.   Biomaterials Science

Recent Advances of Vaccine Adjuvants for Infectious Diseases

(2015) Sujin Lee et al.   Immune Network

Dextran derivative-based pH-sensitive liposomes for cancer immunotherapy

(2014) Eiji Yuba et al.   BIOMATERIALS

Caged protein nanoparticles for drug delivery

(2014) Nicholas M Molino et al.   CURRENT OPINION IN BIOTECHNOLOGY

Liposomes as Nanovaccine Delivery Systems

(2014) Khairunnisa Ghaffar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent advances in peptide-based subunit nanovaccines

(2014) Mariusz Skwarczynski et al.   Nanomedicine

Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo

(2014) HIROKO TOYOTA et al.   ONCOLOGY REPORTS

OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis

(2014) Noriko Yanase et al.   VACCINE

Preparation and evaluation of antigen/N-trimethylaminoethylmethacrylate chitosan conjugates for nasal immunization

(2014) Qingfeng Liu et al.   VACCINE

Biomimetic Protein Nanoparticles Facilitate Enhanced Dendritic Cell Activation and Cross-Presentation

(2013) Nicholas M. Molino et al.   ACS Nano

Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

(2013) Kenichi Niikura et al.   ACS Nano

pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

(2013) John T. Wilson et al.   ACS Nano

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles

(2013) Armando Stano et al.   BIOMATERIALS

Modern Subunit Vaccines: Development, Components, and Research Opportunities

(2013) Peter Michael Moyle et al.   ChemMedChem

The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals

(2013) D. Zeng et al.   JOURNAL OF NUCLEAR MEDICINE

Emerging Research and Clinical Development Trends of Liposome and Lipid Nanoparticle Drug Delivery Systems

(2013) John C. Kraft et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Peptide Conjugation via CuAAC ‘Click’ Chemistry

(2013) Abdullah Ahmad Fuaad et al.   MOLECULES

Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (DC)-based vaccine development

(2013) Jae-A Han et al.   Nanomedicine-Nanotechnology Biology and Medicine

Gold nanorod vaccine for respiratory syncytial virus

(2013) John W Stone et al.   NANOTECHNOLOGY

Vaccine delivery using nanoparticles

(2013) Anthony E. Gregory et al.   Frontiers in Cellular and Infection Microbiology

Liposome-based delivery system for vaccine candidates: constructing an effective formulation

(2012) Ashwini Kumar Giddam et al.   Nanomedicine

Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity

(2012) Martin Kreutz et al.   PLoS One

Vault Nanocapsules as Adjuvants Favor Cell-Mediated over Antibody-Mediated Immune Responses following Immunization of Mice

(2012) Upendra K. Kar et al.   PLoS One

Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity

(2012) A.E. Gregory et al.   VACCINE

Fabrication and optimization of alginate hydrogel constructs for use in 3D neural cell culture

(2011) J P Frampton et al.   Biomedical Materials

Cellular Consequences of Copper Complexes Used To Catalyze Bioorthogonal Click Reactions

(2011) David C. Kennedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of surface charge density in cationic liposome-promoted dendritic cell maturation and vaccine-induced immune responses

(2011) Yifan Ma et al.   Nanoscale

Principles of conjugating quantum dots to proteins via carbodiimide chemistry

(2011) Fayi Song et al.   NANOTECHNOLOGY

Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth

(2011) Upendra K. Kar et al.   PLoS One

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

(2011) C. Nembrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System

(2010) Mariusz Skwarczynski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

(2010) André J. van der Vlies et al.   BIOCONJUGATE CHEMISTRY

Tresyl-based conjugation of protein antigen to lipid nanoparticles increases antigen immunogenicity

(2010) Anekant Jain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Antigen−Adjuvant Nanoconjugates for Nasal Vaccination: An Improvement over the Use of Nanoparticles?

(2010) Bram Slütter et al.   MOLECULAR PHARMACEUTICS

Antigen Delivery with Poly(Propylacrylic Acid) Conjugation Enhances MHC-1 Presentation and T-Cell Activation

(2009) Suzanne Flanary et al.   BIOCONJUGATE CHEMISTRY

Chemical cross-linking with NHS esters: a systematic study on amino acid reactivities

(2009) Stefanie Mädler et al.   JOURNAL OF MASS SPECTROMETRY

Covalent Immobilization of Proteins on Carbon Nanotubes Using the Cross-Linker 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide—a Critical Assessment

(2008) Yuan Gao et al.   BIOCONJUGATE CHEMISTRY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles

(2008) Ayush Verma et al.   NATURE MATERIALS

Carbon Nanotubes Conjugated to Tumor Lysate Protein Enhance the Efficacy of an Antitumor Immunotherapy

(2008) Jie Meng et al.   Small