Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of Trypanosoma brucei

Exploring TERRA during Leishmania major developmental cycle and continuous in vitro passages

(2021) Edna Gicela Ortiz Morea et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Chromoanagenesis, the mechanisms of a genomic chaos

(2021) F. Pellestor et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

(2021) Yusuke Shiromoto et al.   Nature Communications

TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity

(2021) Yang Mei et al.   Scientific Reports

TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain

(2021) Arpita Saha et al.   NUCLEIC ACIDS RESEARCH

Human RAP 1 specifically protects telomeres of senescent cells from DNA damage

(2020) Liudmyla Lototska et al.   EMBO REPORTS

The dark side of RNA:DNA hybrids

(2020) Alessandra Brambati et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

(2020) Marjia Afrin et al.   mSphere

Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability

(2020) Kez Cleal et al.   TRENDS IN GENETICS

Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks

(2020) Jia-Min Zhang et al.   Cell and Bioscience

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

TbRAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing

(2020) Marjia Afrin et al.   Science Advances

Bring It to an End: Does Telomeres Size Matter?

(2019) Camille Laberthonnière et al.   Cells

Telomeres and telomerase: three decades of progress

(2019) Jerry W. Shay et al.   NATURE REVIEWS GENETICS

Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum

(2019) Xu Zhang et al.   PLOS BIOLOGY

9q34.3 microduplications lead to neurodevelopmental disorders through EHMT1 overexpression

(2019) Maria Teresa Bonati et al.   NEUROGENETICS

Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation

(2019) Emma Briggs et al.   NUCLEIC ACIDS RESEARCH

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

(2019) Lucy Glover et al.   mBio

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

(2019) Joana Faria et al.   Nature Communications

Subtelomeric Rearrangements: Presentation of 21 Probands with Emphasis on Familial Cases

(2019) Ana Rita Soares et al.   Acta Medica Portuguesa

RNA–DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast

(2019) Yan Hu et al.   GENETICS

Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast

(2019) Hiroyuki Irie et al.   PLoS Genetics

TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

(2019) Rosa María Marión et al.   eLife

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes

(2019) Arpita Saha et al.   JOURNAL OF MOLECULAR BIOLOGY

Escaping the immune system by DNA repair and recombination in African trypanosomes

(2019) Núria Sima et al.   Open Biology

The balancing act of R-loop biology: The good, the bad, and the ugly

(2019) Youssef A. Hegazy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Repair: The Search for Homology

(2018) James E. Haber   BIOESSAYS

DNA:RNA hybrids at telomeres - when it is better to be out of the (R) loop

(2018) Shir Toubiana et al.   FEBS Journal

Emerging roles of CST in maintaining genome stability and human disease

(2018) Jason A Stewart   Frontiers in Bioscience-Landmark

Telomere Loop Dynamics in Chromosome End Protection

(2018) David Van Ly et al.   MOLECULAR CELL

Microhomology-mediated end joining: Good, bad and ugly

(2018) Ja-Hwan Seol et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Genome organization and DNA accessibility control antigenic variation in trypanosomes

(2018) Laura S. M. Müller et al.   NATURE

Genome-wide function of MCM-BP in Trypanosoma brucei DNA replication and transcription

(2018) Hee-Sook Kim   NUCLEIC ACIDS RESEARCH

Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion

(2018) Emma Briggs et al.   PLoS Genetics

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

(2018) Marcelo Santos da Silva et al.   PLoS Pathogens

Mild Telomere Dysfunction as a Force for Altering the Adaptive Potential of Subtelomeric Genes

(2017) Jennifer M. O. Mason et al.   GENETICS

Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids

(2017) Jeziel D Damasceno et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

(2017) Marianna Feretzaki et al.   METHODS

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei

(2017) Sophie Ridewood et al.   MOLECULAR MICROBIOLOGY

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

(2017) Nausica Arnoult et al.   NATURE

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

(2017) Mats Wahlgren et al.   NATURE REVIEWS MICROBIOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybrids

(2017) Vishal Nanavaty et al.   NUCLEIC ACIDS RESEARCH

High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres

(2017) Eleanor Young et al.   NUCLEIC ACIDS RESEARCH

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance

(2017) Xuyang Feng et al.   NUCLEIC ACIDS RESEARCH

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge

(2017) Alexander P. Sobinoff et al.   TRENDS IN GENETICS

Chromosome End Repair and Genome Stability in Plasmodium falciparum

(2017) Susannah F. Calhoun et al.   mBio

Mechanisms of Surface Antigenic Variation in the Human Pathogenic Fungus Pneumocystis jirovecii

(2017) Emanuel Schmid-Siegert et al.   mBio

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

(2017) Shira Sagie et al.   Nature Communications

Genetic basis of mycotoxin susceptibility differences between budding yeast isolates

(2017) Xtopher Quispe et al.   Scientific Reports

Mild Telomere Dysfunction as a Force for Altering the Adaptive Potential of Subtelomeric Genes

(2017) Jennifer M. O. Mason et al.   GENETICS

Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei

(2017) Ranjodh Sandhu et al.   Scientific Reports

TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres

(2016) Tatsuya Kibe et al.   MOLECULAR CELL

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms

(2016) Sanaa E. Jehi et al.   PLoS One

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

(2016) Lucy Glover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

(2016) Rekha Rai et al.   Nature Communications

Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei

(2016) Danae Schulz et al.   PLoS Genetics

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

(2016) David Reynolds et al.   PLoS Genetics

Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription

(2016) A. Diman et al.   Science Advances

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Genetic and epigenetic contributors to FSHD

(2015) Lucia Daxinger et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomes

(2015) Igor Cestari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites

(2015) Olga Steinberg-Neifach et al.   Frontiers in Genetics

Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrity

(2014) Sanaa E Jehi et al.   CELL RESEARCH

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances

(2014) Jérôme D. Robin et al.   GENES & DEVELOPMENT

Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection

(2014) David Frescas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427

(2014) George A.M. Cross et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome

(2014) Lucy Glover et al.   NUCLEIC ACIDS RESEARCH

Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity

(2014) Sanaa E. Jehi et al.   NUCLEIC ACIDS RESEARCH

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

(2014) Antonio Porro et al.   Cell Reports

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

(2014) Shaheen Kabir et al.   Cell Reports

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Global Quantitative SILAC Phosphoproteomics Reveals Differential Phosphorylation Is Widespread between the Procyclic and Bloodstream Form Lifecycle Stages of Trypanosoma brucei

(2013) Michael D. Urbaniak et al.   JOURNAL OF PROTEOME RESEARCH

Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes

(2013) Unnati M. Pandya et al.   NUCLEIC ACIDS RESEARCH

MCM-BP Is Required for Repression of Life-Cycle Specific Genes Transcribed by RNA Polymerase I in the Mammalian Infectious Form of Trypanosoma brucei

(2013) Hee-Sook Kim et al.   PLoS One

Role of 53BP1 oligomerization in regulating double-strand break repair

(2013) F. Lottersberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

(2013) Lucy Glover et al.   PLoS Pathogens

A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection

(2012) Zhong Deng et al.   EMBO JOURNAL

Trypanosomal histone γH2A and the DNA damage response

(2012) Lucy Glover et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Trypanosoma bruceiOrc1 is essential for nuclear DNA replication and affects bothVSGsilencing andVSGswitching

(2012) Imaan Benmerzouga et al.   MOLECULAR MICROBIOLOGY

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei

(2012) Sam Alsford et al.   NUCLEIC ACIDS RESEARCH

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Genome-wide Analysis Reveals Extensive Functional Interaction between DNA Replication Initiation and Transcription in the Genome of Trypanosoma brucei

(2012) Calvin Tiengwe et al.   Cell Reports

Telomere Length Affects the Frequency and Mechanism of Antigenic Variation in Trypanosoma brucei

(2012) Galadriel A. Hovel-Miner et al.   PLoS Pathogens

Telomere components as potential therapeutic targets for treating microbial pathogen infections

(2012) Bibo Li   Frontiers in Oncology

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast

(2011) Nahid Iglesias et al.   EMBO REPORTS

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms

(2011) Yong Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The telomeric transcriptome of Schizosaccharomyces pombe

(2011) Amadou Bah et al.   NUCLEIC ACIDS RESEARCH

Identification of Trypanosoma brucei RMI1/BLAP75 Homologue and Its Roles in Antigenic Variation

(2011) Hee-Sook Kim et al.   PLoS One

SIRT6 is required for maintenance of telomere position effect in human cells

(2011) Ruth I. Tennen et al.   Nature Communications

Examination of the Telomere G-overhang Structure in Trypanosoma brucei

(2011) Ranjodh Sandhu et al.   Jove-Journal of Visualized Experiments

The Leishmania amazonensis TRF (TTAGGG repeat binding factor) homologue binds and co-localizes with telomeres

(2010) Marcelo S da Silva et al.   BMC MICROBIOLOGY

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

(2010) Rekha Rai et al.   EMBO JOURNAL

A Shld1-Controlled POT1a Provides Support for Repression of ATR Signaling at Telomeres through RPA Exclusion

(2010) Yi Gong et al.   MOLECULAR CELL

Microhomology-mediated deletion and gene conversion in African trypanosomes

(2010) Lucy Glover et al.   NUCLEIC ACIDS RESEARCH

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

TOPO3α Influences Antigenic Variation by Monitoring Expression-Site-Associated VSG Switching in Trypanosoma brucei

(2010) Hee-Sook Kim et al.   PLoS Pathogens

RAP1 Is Essential for Silencing Telomeric Variant Surface Glycoprotein Genes in Trypanosoma brucei

(2009) Xiaofeng Yang et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity

(2009) Liam J. Morrison et al.   CELLULAR MICROBIOLOGY

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

ActiveVSGExpression Sites inTrypanosoma bruceiAre Depleted of Nucleosomes

(2009) Tara M. Stanne et al.   EUKARYOTIC CELL

Nucleosomes Are Depleted at theVSGExpression Site Transcribed by RNA Polymerase I in African Trypanosomes

(2009) Luisa M. Figueiredo et al.   EUKARYOTIC CELL

The Phosphoproteome of Bloodstream FormTrypanosoma brucei, Causative Agent of African Sleeping Sickness

(2009) Isabelle R. E. Nett et al.   MOLECULAR & CELLULAR PROTEOMICS

Arginine Methylation Regulates Telomere Length and Stability

(2009) T. R. H. Mitchell et al.   MOLECULAR AND CELLULAR BIOLOGY

Rap1 in Candida albicans: an Unusual Structural Organization and a Critical Function in Suppressing Telomere Recombination

(2009) E. Y. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Multiple roles for MRE11 at uncapped telomeres

(2009) Yibin Deng et al.   NATURE

A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei

(2009) Catharine E. Boothroyd et al.   NATURE

CpG-island promoters drive transcription of human telomeres

(2009) S. G. Nergadze et al.   RNA

C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins

(2008) Marcela Raices et al.   CELL

Molecular Population Genetics of Drosophila Subtelomeric DNA

(2008) Jennifer A. Anderson et al.   GENETICS

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions

(2008) Shiran Yehezkel et al.   HUMAN MOLECULAR GENETICS

Variation in the Major Surface Glycoprotein Genes inPneumocystis jirovecii

(2008) Geetha Kutty et al.   JOURNAL OF INFECTIOUS DISEASES

Functional Dissection of Human and Mouse POT1 Proteins

(2008) W. Palm et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae

(2008) Brian Luke et al.   MOLECULAR CELL

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

(2008) L. Glover et al.   NUCLEIC ACIDS RESEARCH

Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei

(2008) Christiane Hertz-Fowler et al.   PLoS One

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

(2008) Y. Chen et al.   SCIENCE

A Histone Methyltransferase Modulates Antigenic Variation in African Trypanosomes

(2008) Luisa M Figueiredo et al.   PLOS BIOLOGY

Telomeric position effect: From the yeast paradigm to human pathologies?

(2007) Alexandre Ottaviani et al.   BIOCHIMIE

Characterization of the expression site of the major surface glycoprotein of human-derived Pneumocystis carinii

(2003) Geetha Kutty et al.   MOLECULAR MICROBIOLOGY