12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes

Regulation of Tissue Inflammation by 12-Lipoxygenases

(2021) Abhishek Kulkarni et al.   Biomolecules

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

A 12‐lipoxygenase‐Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish

(2020) Marimar Hernandez‐Perez et al.   FASEB JOURNAL

Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes

(2020) Marika Falcone et al.   Frontiers in Endocrinology

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity

(2019) Emil R. Unanue et al.   DIABETES

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance

(2018) Eddie A. James et al.   DIABETES

Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice

(2018) Sarah A. Tersey et al.   FASEB JOURNAL

An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic β-Cell Injury, Response, and Prevention

(2018) Abhishek A. Kulkarni et al.   Oxidative Medicine and Cellular Longevity

Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes

(2018) Ariadne Androulidaki et al.   PLoS One

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

(2018) Wei Ying et al.   Cell Metabolism

Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications

(2018) A.D. Dobrian et al.   PHARMACOLOGY & THERAPEUTICS

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

(2017) Stephen T. Ferris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

(2017) Javier A. Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF signaling and macrophages govern fin regeneration in zebrafish larvae

(2017) Mai Nguyen-Chi et al.   Cell Death & Disease

Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset

(2016) Susan J. Burke et al.   BIOFACTORS

glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis

(2015) L. Ye et al.   DEVELOPMENT

Population dynamics of islet-infiltrating cells in autoimmune diabetes

(2015) Angela M. Magnuson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages modulate adult zebrafish tail fin regeneration

(2014) T. A. Petrie et al.   DEVELOPMENT

12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets

(2014) S. A. Tersey et al.   MOLECULAR AND CELLULAR BIOLOGY

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulitis in human type 1 diabetes: a comparison between patients and animal models

(2014) Peter In’t Veld   Seminars in Immunopathology

Effects of combination therapy with dipeptidyl peptidase-IV and histone deacetylase inhibitors in the non-obese diabetic mouse model of type 1 diabetes

(2013) S. M. Cabrera et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development

(2013) Shamina M. Green-Mitchell et al.   PLoS One

Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice

(2012) Y. Yamada et al.   DIABETOLOGIA

Adipose Tissue-Specific Deletion of 12/15-Lipoxygenase Protects Mice from the Consequences of a High-Fat Diet

(2012) Banumathi K. Cole et al.   MEDIATORS OF INFLAMMATION

Mouse Islet of Langerhans Isolation using a Combination of Purified Collagenase and Neutral Protease

(2012) Natalie D. Stull et al.   Jove-Journal of Visualized Experiments

Cyclooxygenases and lipoxygenases in cancer

(2011) Claus Schneider et al.   CANCER AND METASTASIS REVIEWS

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Isolation of Mouse Peritoneal Cavity Cells

(2010) Avijit Ray et al.   Jove-Journal of Visualized Experiments

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Nitroreductase-mediated cell/tissue ablation in zebrafish: a spatially and temporally controlled ablation method with applications in developmental and regeneration studies

(2008) Silvia Curado et al.   Nature Protocols