IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent

NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis

(2021) Carlo De Salvo et al.   JOURNAL OF CLINICAL INVESTIGATION

Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

(2019) Tetsuro Kobayashi et al.   CELL

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses

(2019) Daniele Corridoni et al.   Frontiers in Immunology

Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells

(2019) Thomas P. Chapman et al.   Frontiers in Immunology

Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function

(2019) Lauriane Galle-Treger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate Lymphoid Cell Development: A T Cell Perspective

(2018) Dylan E. Cherrier et al.   IMMUNITY

Cutaneous Nod2 Expression Regulates the Skin Microbiome and Wound Healing in a Murine Model

(2017) Helen Williams et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nod2: The intestinal gate keeper

(2017) Ziad Al Nabhani et al.   PLoS Pathogens

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality

(2016) Han-Yu Shih et al.   CELL

Understanding the regulation of pattern recognition receptors in inflammatory diseases - a ‘Nod’ in the right direction

(2016) Claire L. Feerick et al.   IMMUNOLOGY

NOD2 induces autophagy to control AIEC bacteria infectiveness in intestinal epithelial cells

(2016) Anna Negroni et al.   INFLAMMATION RESEARCH

Human innate lymphoid cells

(2016) Jenny Mjösberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing

(2016) Gregory D. Rak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aberrant Expression of Bacterial Pattern Recognition Receptor NOD2 of Basophils and Microbicidal Peptides in Atopic Dermatitis

(2016) Chun-Kwok Wong et al.   MOLECULES

Nod2: A Critical Regulator of Ileal Microbiota and Crohn’s Disease

(2016) Tabasum Sidiq et al.   Frontiers in Immunology

ATG16L1: A multifunctional susceptibility factor in Crohn disease

(2015) Mohammad Salem et al.   Autophagy

NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation

(2015) Delong Jiao et al.   Cellular & Molecular Immunology

Type 3 innate lymphoid cell depletion is mediated by TLRs in lymphoid tissues of simian immunodeficiency virus–infected macaques

(2015) Huanbin Xu et al.   FASEB JOURNAL

Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production

(2015) Maryam Salimi et al.   JOURNAL OF IMMUNOLOGY

Innate Lymphoid Cells in the Skin

(2015) Brian S. Kim   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TNF-α Producing Innate Lymphoid Cells (ILCs) Are Increased in Active Celiac Disease and Contribute to Promote Intestinal Atrophy in Mice

(2015) Irene Marafini et al.   PLoS One

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Type-2 innate lymphoid cells in human allergic disease

(2014) Jillian L. Barlow et al.   Current Opinion in Allergy and Clinical Immunology

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease

(2014) Warren Strober et al.   IMMUNOLOGICAL REVIEWS

Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils

(2014) Yu-Jin Jeong et al.   IMMUNOLOGY

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-κB Activation

(2014) Bernard Thay et al.   INFECTION AND IMMUNITY

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin

(2014) Brian S. Kim et al.   JOURNAL OF IMMUNOLOGY

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

(2014) Norihiro Nakamura et al.   NATURE

IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

(2013) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

(2013) Aurélie Couturier-Maillard et al.   JOURNAL OF CLINICAL INVESTIGATION

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

(2013) Wei Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy and Crohn's Disease

(2013) Hang Thi Thu Nguyen et al.   Journal of Innate Immunity

The Pattern Recognition Receptor NOD2 Mediates Staphylococcus aureus –Induced IL-17C Expression in Keratinocytes

(2013) Sarah A. Roth et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

(2013) Ben Roediger et al.   NATURE IMMUNOLOGY

Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

(2013) Yasutomo Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF- B Signaling Pathways

(2013) N. Warner et al.   Science Signaling

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

Interplay of autophagy and innate immunity in Crohn's disease: A key immunobiologic feature

(2013) Györgyi Műzes   WORLD JOURNAL OF GASTROENTEROLOGY

The Nucleotide Synthesis Enzyme CAD Inhibits NOD2 Antibacterial Function in Human Intestinal Epithelial Cells

(2012) Amy L. Richmond et al.   GASTROENTEROLOGY

Pattern-recognition receptors in human eosinophils

(2012) Anne Månsson Kvarnhammar et al.   IMMUNOLOGY

The c-Jun N-terminal Kinase (JNK)-binding Protein (JNKBP1) Acts as a Negative Regulator of NOD2 Protein Signaling by Inhibiting Its Oligomerization Process

(2012) Aurore Lecat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomal Degradation of Nod2 Protein Mediates Tolerance to Bacterial Cell Wall Components

(2012) Kyoung-Hee Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod2 deficiency impairs inflammatory and epithelial aspects of the cutaneous wound-healing response

(2012) Laura Campbell et al.   JOURNAL OF PATHOLOGY

RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition

(2012) S. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection

(2011) Alexander A. Navarini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR2 and RIP2 Pathways Mediate Autophagy ofListeria monocytogenesvia Extracellular Signal-regulated Kinase (ERK) Activation

(2011) Paras K. Anand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Crohn's Disease Susceptibility Gene Interactions, a NOD to the Newcomer ATG16L1

(2010) Ken Cadwell   GASTROENTEROLOGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Regulation of Cytokine Secretion in Human CD127+ LTi-like Innate Lymphoid Cells by Toll-like Receptor 2

(2010) Natasha K. Crellin et al.   IMMUNITY

Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2–Toll-like receptor 6 pathway

(2010) Anh Tuan Vu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors

(2010) Terese Petterson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Nonrandom Distribution of Pseudomonas aeruginosa and Staphylococcus aureus in Chronic Wounds

(2009) M. Fazli et al.   JOURNAL OF CLINICAL MICROBIOLOGY

NOD2 regulates hematopoietic cell function during graft-versus-host disease

(2009) Olaf Penack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

NOD2 contributes to cutaneous defense against Staphylococcus aureus through  -toxin-dependent innate immune activation

(2009) P. Hruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: Preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells

(2008) Shigeru Okumura et al.   CLINICAL IMMUNOLOGY