NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses

Innate immune receptors for cross-presentation: The expanding role of NLRs

(2017) Daniele Corridoni et al.   MOLECULAR IMMUNOLOGY

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

(2017) Yang Luo et al.   NATURE GENETICS

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

(2016) Marie Pourcelot et al.   BMC BIOLOGY

The comings and goings of MHC class I molecules herald a new dawn in cross-presentation

(2016) J. Magarian Blander   IMMUNOLOGICAL REVIEWS

Genetic deletion of the bacterial sensor NOD2 improves murine Crohn’s disease-like ileitis independent of functional dysbiosis

(2016) D Corridoni et al.   Mucosal Immunology

STING Signaling the enERGIC Way

(2015) Björn Hiller et al.   Cell Host & Microbe

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

(2015) Peter Canning et al.   CHEMISTRY & BIOLOGY

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

(2015) Andrés Alloatti et al.   IMMUNITY

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

(2015) Mohammad Samie et al.   NATURE IMMUNOLOGY

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

(2015) Ueli Nachbur et al.   Nature Communications

TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation

(2014) Priyanka Nair-Gupta et al.   CELL

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Molecular and Cellular Roles of PI31 (PSMF1) Protein in Regulation of Proteasome Function

(2014) Xiaohua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dual Role of Nod-Like Receptors in Mucosal Innate Immunity and Chronic Intestinal Inflammation

(2014) Daniele Corridoni et al.   Frontiers in Immunology

Proteasome Regulation by ADP-Ribosylation

(2013) Park F. Cho-Park et al.   CELL

The Non-Canonical IκB Kinases IKKε and TBK1 as Potential Targets for the Development of Novel Therapeutic Drugs

(2013) E. Niederberger et al.   CURRENT MOLECULAR MEDICINE

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

(2013) Oliver Brain et al.   IMMUNITY

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

(2013) Amede Larabi et al.   Cell Reports

Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases

(2012) Ricardo G. Correa et al.   BIOSCIENCE REPORTS

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Conserved F Box Regulatory Complex Controls Proteasome Activity in Drosophila

(2011) Maya Bader et al.   CELL

TLR and Nucleotide-Binding Oligomerization Domain-like Receptor Signals Differentially Regulate Exogenous Antigen Presentation

(2011) C. S. Wagner et al.   JOURNAL OF IMMUNOLOGY

Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation

(2011) J. G. Magalhaes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Ca 2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor

(2010) Ji-Li Chen et al.   JOURNAL OF IMMUNOLOGY

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER

(2009) H. Hughes et al.   JOURNAL OF CELL SCIENCE

Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo

(2009) J. Asano et al.   JOURNAL OF IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

Structure of a Conserved Dimerization Domain within the F-box Protein Fbxo7 and the PI31 Proteasome Inhibitor

(2008) Rebecca Kirk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

(2008) Sven Burgdorf et al.   NATURE IMMUNOLOGY