Nod2: The intestinal gate keeper

Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis

(2016) Ziad Alnabhani et al.   INFLAMMATORY BOWEL DISEASES

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Erratum: Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin

(2016) Donghyun Kim et al.   NATURE MEDICINE

Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses

(2016) Qianqian Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Helminth infection promotes colonization resistance via type 2 immunity

(2016) Deepshika Ramanan et al.   SCIENCE

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

(2016) H. Chu et al.   SCIENCE

Crystal structure of NOD2 and its implications in human disease

(2016) Sakiko Maekawa et al.   Nature Communications

Diet Dominates Host Genotype in Shaping the Murine Gut Microbiota

(2015) Rachel N. Carmody et al.   Cell Host & Microbe

The Role of Microbiota on the Gut Immunology

(2015) Yang Won Min et al.   CLINICAL THERAPEUTICS

Dysbiotic gut microbiome: A key element of Crohn's disease

(2015) Styrk Furnes Øyri et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

(2015) E. Denou et al.   EMBO Molecular Medicine

Pseudomonas fluorescens Alters the Intestinal Barrier Function by Modulating IL-1β Expression Through Hematopoietic NOD2 Signaling

(2015) Ziad Alnabhani et al.   INFLAMMATORY BOWEL DISEASES

Intestinal microbiota and ulcerative colitis

(2015) Toshifumi Ohkusa et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

NOD-Like Receptors: Versatile Cytosolic Sentinels

(2015) Vinicius Motta et al.   PHYSIOLOGICAL REVIEWS

PRR-signaling pathways: Learning from microbial tactics

(2015) Gernot Sellge et al.   SEMINARS IN IMMUNOLOGY

Transcription of innate immunity genes and cytokine secretion by canine macrophages resistant or susceptible to intracellular survival of Leishmania infantum

(2015) Andréia Pereira Turchetti et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Commensal Bacterial Endocytosis in Epithelial Cells Is Dependent on Myosin Light Chain Kinase–Activated Brush Border Fanning by Interferon-γ

(2014) Li-Ling Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Structural mechanisms in NLR inflammasome signaling

(2014) Bernhard C Lechtenberg et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-κB Activation

(2014) Bernard Thay et al.   INFECTION AND IMMUNITY

Cross-Tolerization between Nod1 and Nod2 Signaling Results in Reduced Refractoriness to Bacterial Infection in Nod2-Deficient Macrophages

(2014) Y.-G. Kim et al.   JOURNAL OF IMMUNOLOGY

Nucleotide-Binding Oligomerization Domain–Containing Protein 2 Controls Host Response to Campylobacter jejuni in Il10−/− Mice

(2014) Xiaolun Sun et al.   JOURNAL OF INFECTIOUS DISEASES

Nucleotide Oligomerization and Binding Domain 2-Dependent Dendritic Cell Activation Is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection

(2014) C. Lupfer et al.   JOURNAL OF VIROLOGY

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

(2014) Norihiro Nakamura et al.   NATURE

Citrobacter rodentium: infection, inflammation and the microbiota

(2014) James W. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Activation of Nucleotide Oligomerization Domain 2 (NOD2) by Human Cytomegalovirus Initiates Innate Immune Responses and Restricts Virus Replication

(2014) Arun Kapoor et al.   PLoS One

Nucleotide-Oligomerization-Domain-2 Affects Commensal Gut Microbiota Composition and Intracerebral Immunopathology in Acute Toxoplasma gondii Induced Murine Ileitis

(2014) Markus M. Heimesaat et al.   PLoS One

Complex host genetics influence the microbiome in inflammatory bowel disease

(2014) Dan Knights et al.   Genome Medicine

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

(2014) Jeanette Wagener et al.   PLoS Pathogens

Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection

(2014) Christopher R. Lupfer et al.   PLoS Pathogens

Pseudomonas fluorescens can induce and divert the human β-defensin-2 secretion in intestinal epithelial cells to enhance its virulence

(2013) Amar Madi et al.   ARCHIVES OF MICROBIOLOGY

NOD2/CARD15 Single Nucleotide Polymorphism 13 (3020insC) is Associated with Risk of Sepsis and Single Nucleotide Polymorphism 8 (2104C>T) with Herpes Viruses Reactivation in Patients after Allogeneic Hematopoietic Stem Cell Transplantation

(2013) Emilia Jaskula et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

A Deficiency in the Autophagy Gene Atg16L1 Enhances Resistance to Enteric Bacterial Infection

(2013) Amanda M. Marchiando et al.   Cell Host & Microbe

Mouse Paneth cell antimicrobial function is independent of Nod2

(2013) Michael T Shanahan et al.   GUT

Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms

(2013) A Amendola et al.   Mucosal Immunology

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

(2013) Shuo Yang et al.   NATURE IMMUNOLOGY

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

Dectin-1/TLR2 and NOD2 Agonists Render Dendritic Cells Susceptible to Infection by X4-Using HIV-1 and Promote cis-Infection of CD4+ T Cells

(2013) Sandra C. Côté et al.   PLoS One

RIP2/RICK-Dependent Cytokine Production UponYersinia enterocoliticaInfection in Macrophages with TLR4 Deficiency

(2013) Y.-J. Jeong et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Functions of NOD-Like Receptors in Human Diseases

(2013) Yifei Zhong et al.   Frontiers in Immunology

Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

(2012) Ulrich Meinzer et al.   Cell Host & Microbe

Respiratory syncytial virus infection augments NOD2 signaling in an IFN-β-dependent manner in human primary cells

(2012) Marloes Vissers et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NOD2 Signaling Contributes to Host Defense in the Lungs against Escherichia coli Infection

(2012) Balamayooran Theivanthiran et al.   INFECTION AND IMMUNITY

AIEC colonization and pathogenicity: Influence of previous antibiotic treatment and preexisting inflammation

(2012) Maryline Drouet et al.   INFLAMMATORY BOWEL DISEASES

Pathogen Sensing by Nucleotide-binding Oligomerization Domain-containing Protein 2 (NOD2) Is Mediated by Direct Binding to Muramyl Dipeptide and ATP

(2012) Jinyao Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling

(2012) Camille Jung et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleotide-binding oligomerization domain 2 (Nod2) is dispensable for the innate immune responses of macrophages against Yersinia enterocolitica

(2012) Yu-Jin Jeong et al.   JOURNAL OF MICROBIOLOGY

The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

(2012) Catherine Leimkuhler Grimes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inflammatory Bowel Diseases Phenotype, C. difficile and NOD2 Genotype Are Associated with Shifts in Human Ileum Associated Microbial Composition

(2012) Ellen Li et al.   PLoS One

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Escherichia coli: Great Diversity around a Common Core

(2012) D. G. Moriel et al.   mBio

Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections

(2011) Yun-Gi Kim et al.   Cell Host & Microbe

Nod2 is essential for temporal development of intestinal microbial communities

(2011) A. Rehman et al.   GUT

Altered gut microbiota composition in immune-impairedNod2−/−mice

(2011) Stanislas Mondot et al.   GUT

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Variants of NOD1 and NOD2 genes display opposite associations with familial risk of crohnʼs disease and anti-saccharomyces cerevisiae antibody levels

(2011) Francis Vasseur et al.   INFLAMMATORY BOWEL DISEASES

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

(2011) Benoit Chassaing et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

(2011) Kaoru Geddes et al.   NATURE MEDICINE

Gnotobiotic IL-10−/−; NF-κBEGFP Mice Develop Rapid and Severe Colitis Following Campylobacter jejuni Infection

(2011) Elisabeth Lippert et al.   PLoS One

Pseudomonas fluorescens alters epithelial permeability and translocates across Caco-2/TC7 intestinal cells

(2011) Amar Madi et al.   Gut Pathogens

Cell-associated hemolysis activity in the clinical strain of Pseudomonas fluorescens MFN1032

(2010) Daniel Sperandio et al.   BMC MICROBIOLOGY

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors

(2010) Terese Petterson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer

(2010) J G Fox et al.   Mucosal Immunology

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

(2010) A. Biswas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches

(2009) F. Barreau et al.   GUT

NOD2 regulates hematopoietic cell function during graft-versus-host disease

(2009) Olaf Penack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Listeria monocytogenes-Infected Human Peripheral Blood Mononuclear Cells Produce IL-1 , Depending on Listeriolysin O and NLRP3

(2009) K. Meixenberger et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

(2009) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

(2009) Michael H Shaw et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase-12 and the Inflammatory Response to Yersinia pestis

(2009) Bart Ferwerda et al.   PLoS One

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative study of 7 fluorescent pseudomonad clinical isolates

(2008) A. Chapalain et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: Preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells

(2008) Shigeru Okumura et al.   CLINICAL IMMUNOLOGY

Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

(2008) Liping Su et al.   GASTROENTEROLOGY

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

Campylobacter-Induced Interleukin-8 Secretion in Polarized Human Intestinal Epithelial Cells Requires Campylobacter-Secreted Cytolethal Distending Toxin- and Toll-Like Receptor-Mediated Activation of NF- B

(2008) J. Zheng et al.   INFECTION AND IMMUNITY

Nod2 Mediates Susceptibility to Yersinia pseudotuberculosis in Mice

(2008) Ulrich Meinzer et al.   PLoS One

Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen

(2008) Jess H. Leber et al.   PLoS Pathogens

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA