Regulation of Extracellular Matrix Production in Activated Fibroblasts: Roles of Amino Acid Metabolism in Collagen Synthesis
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Title
Regulation of Extracellular Matrix Production in Activated Fibroblasts: Roles of Amino Acid Metabolism in Collagen Synthesis
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-09-03
DOI
10.3389/fonc.2021.719922
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Note: Only part of the references are listed.- Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer
- (2021) Yang Chen et al. CANCER CELL
- Mitochondrial NADP(H) generation is essential for proline biosynthesis
- (2021) Jiajun Zhu et al. SCIENCE
- Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches
- (2020) Jess D. Hebert et al. CANCER RESEARCH
- Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress
- (2020) Simon Schwörer et al. EMBO JOURNAL
- Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis
- (2020) Hsiu‐Wen Tsai et al. LARYNGOSCOPE
- Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
- (2020) David H. Peng et al. Nature Communications
- Concepts of extracellular matrix remodelling in tumour progression and metastasis
- (2020) Juliane Winkler et al. Nature Communications
- In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1
- (2020) Emily M. Christensen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HIF-1α metabolically controls collagen synthesis and modification in chondrocytes
- (2019) Steve Stegen et al. NATURE
- Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling
- (2019) Kexin Sun et al. EBioMedicine
- Breast cancer cells rely on environmental pyruvate to shape the metastatic niche
- (2019) Ilaria Elia et al. NATURE
- Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts
- (2019) Robert B Hamanaka et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis
- (2019) Brintha Selvarajah et al. Science Signaling
- Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities
- (2019) Sung-Tzu Liang et al. Cells
- A fragment-like approach to PYCR1 inhibition
- (2019) Kirsty Milne et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery
- (2019) Prakash Lingasamy et al. BIOMATERIALS
- Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate–mediated mTOR Activation and Proline Hydroxylation
- (2018) Jing Ge et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis
- (2018) Patricia de Paz-Lugo et al. AMINO ACIDS
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
- (2018) Thomas Bertero et al. Cell Metabolism
- The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
- (2018) Hannah V. Woodcock et al. Nature Communications
- Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation
- (2017) Karen Bernard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis
- (2017) Hadi Khalil et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting metabolic abnormalities to reverse fibrosis in iatrogenic laryngotracheal stenosis
- (2017) Michael K. Murphy et al. LARYNGOSCOPE
- Exogenous proline stimulates type I collagen and HIF-1α expression and the process is attenuated by glutamine in human skin fibroblasts
- (2017) Lukasz Szoka et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1
- (2017) N Cohen et al. ONCOGENE
- Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism
- (2017) Jiang Li et al. PLoS One
- Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer
- (2017) Feng Cai et al. Oncology Letters
- Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
- (2017) Orianne Olivares et al. Nature Communications
- α3 Chains of type V collagen regulate breast tumour growth via glypican-1
- (2017) Guorui Huang et al. Nature Communications
- Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
- (2017) Juan R. Hernandez-Fernaud et al. Nature Communications
- Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
- (2017) A J Rice et al. Oncogenesis
- Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
- (2016) Lifeng Yang et al. Cell Metabolism
- Transforming Growth Factor (TGF)-β Promotesde NovoSerine Synthesis for Collagen Production
- (2016) Recep Nigdelioglu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
- (2016) Cristovão M. Sousa et al. NATURE
- Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
- (2016) T Yu et al. ONCOGENE
- PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress
- (2016) Mei-Ling Kuo et al. Scientific Reports
- Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
- (2016) Hongyun Zhao et al. eLife
- Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis
- (2015) Na Xie et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer
- (2015) C. J. Whatcott et al. CLINICAL CANCER RESEARCH
- Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance
- (2015) C. Duluc et al. EMBO Molecular Medicine
- Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort
- (2015) J A Schmidt et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
- (2015) Spencer C. Wei et al. NATURE CELL BIOLOGY
- Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides
- (2015) Wei Liu et al. Scientific Reports
- The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts
- (2015) Anna Kuchnio et al. Cell Reports
- Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
- (2015) Daoxiang Zhang et al. Cell Reports
- Tumors: Wounds That Do Not Heal--Redux
- (2015) H. F. Dvorak Cancer Immunology Research
- The extracellular matrix modulates the hallmarks of cancer
- (2014) M. W. Pickup et al. EMBO REPORTS
- A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling
- (2014) Y. H. Bae et al. Science Signaling
- Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters
- (2014) Alexandra Naba et al. eLife
- Collagen architecture in pregnancy-induced protection from breast cancer
- (2013) O. Maller et al. JOURNAL OF CELL SCIENCE
- Local Arginase 1 Activity Is Required for Cutaneous Wound Healing
- (2013) Laura Campbell et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer
- (2013) Yoshinori Ino et al. PLoS One
- Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production
- (2012) Claudia Capparelli et al. CELL CYCLE
- Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production
- (2012) Carmela Guido et al. CELL CYCLE
- HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
- (2012) R V Durán et al. ONCOGENE
- Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1, encoding Δ1-pyrroline-5-carboxylate synthase (P5CS)
- (2011) David L. Skidmore et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis
- (2011) Stephanos Pavlides et al. ANTIOXIDANTS & REDOX SIGNALING
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Evidence for a stromal-epithelial “lactate shuttle” in human tumors
- (2011) Diana Whitaker-Menezes et al. CELL CYCLE
- Protein export at the ER: loading big collagens into COPII carriers
- (2011) Vivek Malhotra et al. EMBO JOURNAL
- Defect in proline synthesis: pyrroline-5-carboxylate reductase 1 deficiency leads to a complex clinical phenotype with collagen and elastin abnormalities
- (2011) Rita Kretz et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants
- (2011) Audrey Dooley et al. Cardiology Research and Practice
- HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells
- (2010) Barbara Chiavarina et al. CELL CYCLE
- The extracellular matrix at a glance
- (2010) C. Frantz et al. JOURNAL OF CELL SCIENCE
- Mutations in PYCR1 cause cutis laxa with progeroid features
- (2009) Bruno Reversade et al. NATURE GENETICS
- Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model
- (2009) Debbie Liao et al. PLoS One
- Integrin 1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
- (2009) T. Shibue et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Collagen density promotes mammary tumor initiation and progression
- (2008) Paolo P Provenzano et al. BMC Medicine
- Functional role and species-specific contribution of arginases in pulmonary fibrosis
- (2007) Kamila Kitowska et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells
- (2007) Annette S. Vincent et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
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