The Role of Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood

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Nutrients and Microbiota in Lung Diseases of Prematurity: The Placenta-Gut-Lung Triangle

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Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis

(2020) Stephen Wedgwood et al.   Frontiers in Immunology

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

(2020) Tao Zuo et al.   GASTROENTEROLOGY

NSCLC Immunotherapy Efficacy and Antibiotic Use: A Systematic Review and Meta-Analysis

(2020) Lise Lurienne et al.   Journal of Thoracic Oncology

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

(2020) Clélia Coutzac et al.   Nature Communications

Relationship between intestinal flora structure and metabolite analysis and immunotherapy efficacy in Chinese NSCLC patients

(2020) Peng Song et al.   Thoracic Cancer

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation

(2020) Jing Ouyang et al.   Frontiers in Immunology

Specific gut microbiome signature predicts the early-stage lung cancer

(2020) Yajuan Zheng et al.   Gut Microbes

Increased Th17 activation and gut microbiota diversity are associated with pembrolizumab-triggered tuberculosis

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Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic

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Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

(2020) Lukas F. Mager et al.   SCIENCE

Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice

(2020) Shanna L. Ashley et al.   Science Translational Medicine

Association of Probiotic Clostridium butyricum Therapy with Survival and Response to Immune Checkpoint Blockade in Patients with Lung Cancer

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Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model

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Altered gut microbiota correlated with systemic inflammation in children with Kawasaki disease

(2020) Jie Chen et al.   Scientific Reports

The Gut Microbiome Is Associated with Clinical Response to Anti–PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer

(2020) Zhi Peng et al.   Cancer Immunology Research

Network Analysis of Gut Microbiome and Metabolome to Discover Microbiota-Linked Biomarkers in Patients Affected by Non-Small Cell Lung Cancer

(2020) Pamela Vernocchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway

(2020) Jia Tang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder

(2019) Simeng Liu et al.   Scientific Reports

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

(2019) Nobuhiro Nakamoto et al.   Nature Microbiology

Gut microbiota in HIV–pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction

(2019) Meera K. Shenoy et al.   Microbiome

The human gut bacterial genotoxin colibactin alkylates DNA

(2019) Matthew R. Wilson et al.   SCIENCE

GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites

(2019) Naoki Morita et al.   NATURE

Integrative Analysis of the Intestinal Metabolome of Childhood Asthma

(2019) Kathleen A. Lee-Sarwar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity

(2019) Eric M. Brown et al.   Annual Review of Immunology

Intestinal microbiota predicts lung cancer patients at risk of immune-related diarrhea

(2019) Tian Liu et al.   Immunotherapy

Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

(2019) Anna Theiler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The diversity of gut microbiome is associated with favorable responses to anti-PD-1 immunotherapy in Chinese non-small cell lung cancer patients

(2019) Yueping Jin et al.   Journal of Thoracic Oncology

Microbes, metabolites, and the gut–lung axis

(2019) Anh Thu Dang et al.   Mucosal Immunology

Dysbiosis of the Gut Microbiome in Lung Cancer

(2019) He Zhuang et al.   Frontiers in Cellular and Infection Microbiology

The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients

(2019) Yongfei Hu et al.   Frontiers in Cellular and Infection Microbiology

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

(2019) Kwangkho Kim et al.   Molecular Medicine Reports

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

(2019) Shinichi Yachida et al.   NATURE MEDICINE

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

(2019) Anthony T. Virtue et al.   Science Translational Medicine

Gut Microbiota Regulates Mincle Mediated Activation of Lung Dendritic Cells to Protect Against Mycobacterium tuberculosis

(2019) Shikha Negi et al.   Frontiers in Immunology

Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance

(2019) Sophia R. Levan et al.   Nature Microbiology

Immunomodulatory effects of Lactobacillus plantarum on inflammatory response induced by Klebsiella pneumoniae

(2019) Marjolaine Vareille-Delarbre et al.   INFECTION AND IMMUNITY

The influence of the microbiome on respiratory health

(2019) Tomasz P. Wypych et al.   NATURE IMMUNOLOGY

Structure elucidation of colibactin and its DNA cross-links

(2019) Mengzhao Xue et al.   SCIENCE

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation

(2019) Gavin Lewis et al.   Frontiers in Immunology

Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer

(2019) David J. Pinato et al.   JAMA Oncology

The effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing immune checkpoint inhibitor treatment: a retrospective study

(2019) Hyunho Kim et al.   BMC CANCER

Characterization of gut microbiota in children with pulmonary tuberculosis

(2019) Weiran Li et al.   BMC Pediatrics

Predictive impact of antibiotics in patients with advanced non small-cell lung cancer receiving immune checkpoint inhibitors

(2019) Anne Schett et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Gastrointestinal Tract Dysbiosis Enhances Distal Tumor Progression through Suppression of Leukocyte Trafficking

(2019) Samir V. Jenkins et al.   CANCER RESEARCH

Association of Dietary Fiber and Yogurt Consumption With Lung Cancer Risk

(2019) Jae Jeong Yang et al.   JAMA Oncology

Toxins and mobile antimicrobial resistance genes in Bacillus probiotics constitute a potential risk for One Health

(2019) Yifang Cui et al.   JOURNAL OF HAZARDOUS MATERIALS

Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer

(2018) L Derosa et al.   ANNALS OF ONCOLOGY

Impact of gut colonization with butyrate producing microbiota on respiratory viral infection following allo-HCT

(2018) Bastiaan W. Haak et al.   BLOOD

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

(2018) Vancheswaran Gopalakrishnan et al.   CANCER CELL

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

(2018) Liam Chung et al.   Cell Host & Microbe

Recirculating Immunocompetent Cells in Colitic Mice Intensify Their Lung Response to Bacterial Endotoxin

(2018) Ahmed Metwali et al.   DIGESTIVE DISEASES AND SCIENCES

Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants

(2018) Huey-Huey Chua et al.   GASTROENTEROLOGY

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Maturation of the gut microbiome and risk of asthma in childhood

(2018) Jakob Stokholm et al.   Nature Communications

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Bacterial secretion of histamine within the gut influences immune responses within the lung

(2018) Weronika Barcik et al.   ALLERGY

Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin

(2018) Zhen He et al.   GUT

Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli

(2018) Zhen Zhang et al.   Scientific Reports

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

Evaluating Causality of Gut Microbiota in Obesity and Diabetes in Humans

(2017) Abraham S Meijnikman et al.   ENDOCRINE REVIEWS

D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease

(2017) Inge Kepert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial

(2017) Roberto Berni Canani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids

(2017) A Cait et al.   Mucosal Immunology

Oral administration of Saccharomyces cerevisiae UFMG A-905 prevents allergic asthma in mice

(2017) Vanessa M.B. Fonseca et al.   RESPIROLOGY

Oral administration of Clostridium butyricum CGMCC0313-1 reduces ovalbumin-induced allergic airway inflammation in mice

(2017) Zhang Juan et al.   RESPIROLOGY

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection

(2017) Jerilyn Gray et al.   Science Translational Medicine

Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models

(2017) Meng-Yun Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

Prophylactic Supplementation of Bifidobacterium longum 51A Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsiveness

(2017) Eduardo Mendes et al.   Frontiers in Microbiology

Macrophages, Inflammation, and Lung Cancer

(2016) Emma M. Conway et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Management of toxicities of immune checkpoint inhibitors

(2016) Lavinia Spain et al.   CANCER TREATMENT REVIEWS

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Gut–lung axis: The microbial contributions and clinical implications

(2016) Yang He et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis

(2016) Vanessa Graillot et al.   Frontiers in Cellular and Infection Microbiology

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Circulating Inflammation Markers, Risk of Lung Cancer, and Utility for Risk Stratification

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Recombinant fragilysin isoforms cause E-cadherin cleavage of intact cells and do not cleave isolated E-cadherin

(2015) Daria Kharlampieva et al.   MICROBIAL PATHOGENESIS

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Circulating Inflammation Markers, Risk of Lung Cancer, and Utility for Risk Stratification

(2015) Meredith S. Shiels et al.   JNCI-Journal of the National Cancer Institute

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

(2014) Ryoko Kibe et al.   Scientific Reports

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Consistent activation of the β-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine

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From single-strand breaks to double-strand breaks during S-phase: a new mode of action of theEscherichia coli Cytolethal Distending Toxin

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Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

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Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Chronic Effects of a Salmonella Type III Secretion Effector Protein AvrA In Vivo

(2010) Rong Lu et al.   PLoS One

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY