Gut–lung axis: The microbial contributions and clinical implications

Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier

(2017) Shui-Jiao Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant

(2016) Kannikar Vongbhavit et al.   CLINICAL THERAPEUTICS

Alterations of lung microbiota in a mouse model of LPS-induced lung injury

(2015) Valeriy Poroyko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6

(2015) L. Orivuori et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The bacterial microbiota in inflammatory lung diseases

(2015) Gary B. Huffnagle et al.   CLINICAL IMMUNOLOGY

The pediatric microbiome and the lung

(2015) Michael Tracy et al.   CURRENT OPINION IN PEDIATRICS

Role of infection in exacerbations of chronic obstructive pulmonary disease

(2015) Marc Miravitlles et al.   CURRENT OPINION IN PULMONARY MEDICINE

Gut microbiota modulate the immune effect against hepatitis B virus infection

(2015) D. Xu et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

The microbiome in asthma

(2015) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Induction of Th17 cells by segmented filamentous bacteria in the murine intestine

(2015) Adam M. Farkas et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Associations between Gut Microbial Colonization in Early Life and Respiratory Outcomes in Cystic Fibrosis

(2015) Anne G. Hoen et al.   JOURNAL OF PEDIATRICS

A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock

(2015) Koji Morishita et al.   Journal of Trauma and Acute Care Surgery

The role of the local microbial ecosystem in respiratory health and disease

(2015) Wouter A. A. de Steenhuijsen Piters et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice

(2015) Arun Prakash et al.   SHOCK

Innate and adaptive cellular phenotypes contributing to pulmonary disease in mice after respiratory syncytial virus immunization and infection

(2015) Young-Tae Lee et al.   VIROLOGY

Regulation of lung immunity and host defense by the intestinal microbiota

(2015) Derrick R. Samuelson et al.   Frontiers in Microbiology

A pharmacologic approach to vagal nerve stimulation prevents mesenteric lymph toxicity after hemorrhagic shock

(2015) Koji Morishita et al.   Journal of Trauma and Acute Care Surgery

Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease

(2015) Marius Vital et al.   Journal of Immunology Research

An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice

(2014) Michael M. Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lung-Gut Cross Talk

(2014) Simon Keely et al.   CHEST

Nutrition in the ICU

(2014) Svetang V. Desai et al.   CHEST

Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease

(2014) Huaying Wang et al.   Clinical Respiratory Journal

Mucosal Barrier, Bacteria and Inflammatory Bowel Disease: Possibilities for Therapy

(2014) Yvette Merga et al.   DIGESTIVE DISEASES

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

(2014) Mairi H McLean et al.   GUT

Novel insights in preventing Gram-negative bacterial infection in cirrhotic patients: review on the effects of GM-CSF in maintaining homeostasis of the immune system

(2014) Dong Xu et al.   Hepatology International

Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense

(2014) Jeremy P. McAleer et al.   IMMUNOLOGICAL REVIEWS

Antibiotics and the gut microbiota

(2014) Sheetal R. Modi et al.   JOURNAL OF CLINICAL INVESTIGATION

Severity-Related Changes of Bronchial Microbiome in Chronic Obstructive Pulmonary Disease

(2014) M. Garcia-Nunez et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Neutrophil elastase-mediated increase in airway temperature during inflammation

(2014) Annika Schmidt et al.   Journal of Cystic Fibrosis

The role of the microbiome in exacerbations of chronic lung diseases

(2014) Robert P Dickson et al.   LANCET

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Cigarette Smoking Promotes Inflammation in Patients with COPD by Affecting the Polarization and Survival of Th/Tregs through Up-Regulation of Muscarinic Receptor 3 and 5 Expression

(2014) Ming-Qiang Zhang et al.   PLoS One

Changes in the Bacterial Microbiota in Gut, Blood, and Lungs following Acute LPS Instillation into Mice Lungs

(2014) Marc A. Sze et al.   PLoS One

Dynamic Changes in Rat Mesenteric Lymph Proteins Following Trauma Using Label-Free Mass Spectrometry

(2014) Angelo D’Alessandro et al.   SHOCK

Lymph Is Not a Plasma Ultrafiltrate

(2014) Monika Dzieciatkowska et al.   SHOCK

Instilled air promotes lipopolysaccharide-induced acute lung injury

(2014) YINGGANG ZOU et al.   Experimental and Therapeutic Medicine

Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Philip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The murine lung microbiome in relation to the intestinal and vaginal bacterial communities

(2013) Kenneth Barfod et al.   BMC MICROBIOLOGY

Disturbed Intestinal Integrity in Patients With COPD

(2013) Erica P.A. Rutten et al.   CHEST

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

The Effect of Probiotics and Gut Microbiota on Th17 Cells

(2013) Soichi Tanabe   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Oral pretreatment with recombinant human lactoferrin limits trauma-hemorrhagic shock–induced gut injury and the biological activity of mesenteric lymph

(2013) Julie Y. Son et al.   JOURNAL OF SURGICAL RESEARCH

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversible Control by Vitamin D of Granulocytes and Bacteria in the Lungs of Mice: An Ovalbumin-Induced Model of Allergic Airway Disease

(2013) Shelley Gorman et al.   PLoS One

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Parasympathetic Stimulation Via the Vagus Nerve Prevents Systemic Organ Dysfunction by Abrogating Gut Injury and Lymph Toxicity in Trauma and Hemorrhagic Shock

(2013) Misha D. Luyer et al.   SHOCK

Microbial communities in the respiratory tract of patients with interstitial lung disease

(2013) Christian Garzoni et al.   THORAX

Redefining the gut as the motor of critical illness

(2013) Rohit Mittal et al.   TRENDS IN MOLECULAR MEDICINE

Interkingdom Signaling Induces Streptococcus pneumoniae Biofilm Dispersion and Transition from Asymptomatic Colonization to Disease

(2013) L. R. Marks et al.   mBio

The role of the bacterial microbiome in lung disease

(2013) Robert P Dickson et al.   Expert Review of Respiratory Medicine

Secretory IgA: Designed for Anti-Microbial Defense

(2013) Per Brandtzaeg   Frontiers in Immunology

Unique microbial communities persist in individual cystic fibrosis patients throughout a clinical exacerbation

(2013) Katherine E Price et al.   Microbiome

Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System

(2012) Todd W. Costantini et al.   AMERICAN JOURNAL OF PATHOLOGY

The Microbiota in Respiratory Disease

(2012) John R. Erb-Downward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease

(2012) Marc A. Sze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Comparative Study of Trans-Oral and Trans-Tracheal Intratracheal Instillations in a Murine Model of Acute Lung Injury

(2012) Ling Liu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Alveolar Macrophages and Toll-like Receptor 4 Mediate Ventilated Lung Ischemia Reperfusion Injury in Mice

(2012) Arun Prakash et al.   ANESTHESIOLOGY

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Immunoregulation by the gut microbiota

(2012) Junko Nishio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The induction of Treg cells by gut-indigenous Clostridium

(2012) Yuji Nagano et al.   CURRENT OPINION IN IMMUNOLOGY

Probiotic/Synbiotic Therapy for Treating Critically Ill Patients from a Gut Microbiota Perspective

(2012) Kentaro Shimizu et al.   DIGESTIVE DISEASES AND SCIENCES

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure

(2012) Huaying Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Asthma-associated differences in microbial composition of induced sputum

(2012) Pradeep Reddy Marri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial

(2012) Conroy Wong et al.   LANCET

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

(2012) Alexa A. Pragman et al.   PLoS One

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Immuno-microbiota cross and talk: The new paradigm of metabolic diseases

(2012) Rémy Burcelin et al.   SEMINARS IN IMMUNOLOGY

Mechanisms of Methicillin-Resistant Staphylococcus aureus Pneumonia–Induced Intestinal Epithelial Apoptosis

(2012) Erin E. Perrone et al.   SHOCK

The Endogenous Bacteria Alter Gut Epithelial Apoptosis and Decrease Mortality Following Pseudomonas aeruginosa Pneumonia

(2012) Amy C. Fox et al.   SHOCK

Significance of the microbiome in obstructive lung disease

(2012) MeiLan K Han et al.   THORAX

The microbiome of the lung

(2012) James M. Beck et al.   Translational Research

Antibiotics, microbiota, and immune defense

(2012) Carles Ubeda et al.   TRENDS IN IMMUNOLOGY

Potential of Nasopharynx-associated Lymphoid Tissue for Vaccine Responses in the Airways

(2011) Per Brandtzaeg   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official American Thoracic Society Research Statement: Noninfectious Lung Injury after Hematopoietic Stem Cell Transplantation: Idiopathic Pneumonia Syndrome

(2011) Angela Panoskaltsis-Mortari et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Strategies to Prevent or Reduce Allergic Disease

(2011) Susan Prescott et al.   ANNALS OF NUTRITION AND METABOLISM

The microstructure of secondary lymphoid organs that support immune cell trafficking

(2011) Kenjiro Matsuno et al.   ARCHIVES OF HISTOLOGY AND CYTOLOGY

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

(2011) Alan W Walker et al.   BMC MICROBIOLOGY

Dietary Immunomodulatory Factors in the Development of Immune Tolerance

(2011) Christina E. West et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Probiotics and immune health

(2011) Fang Yan et al.   CURRENT OPINION IN GASTROENTEROLOGY

The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation

(2011) Lee J. McGhan et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Gut microbiota, probiotics, and vitamin D: Interrelated exposures influencing allergy, asthma, and obesity?

(2011) Ngoc P. Ly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma

(2011) Rachel M. McLoughlin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR4 Mediates Lung Injury and Inflammation in Intestinal Ischemia-Reperfusion

(2011) Dao-Feng Ben et al.   JOURNAL OF SURGICAL RESEARCH

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Azithromycin for Prevention of Exacerbations of COPD

(2011) Richard K. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease

(2011) María Inés Vargas-Rojas et al.   RESPIRATORY MEDICINE

Microbiotal influence on T cell subset development

(2011) Koji Atarashi et al.   SEMINARS IN IMMUNOLOGY

Intestinal microbiota: Shaping local and systemic immune responses

(2011) Michael J. Molloy et al.   SEMINARS IN IMMUNOLOGY

Proteomic Analysis of Human Mesenteric Lymph

(2011) Monika Dzieciatkowska et al.   SHOCK

Commensal Microflora Contribute to Host Defense Against Escherichia Coli Pneumonia Through Toll-Like Receptors

(2011) Lee-Wei Chen et al.   SHOCK

Efferent vagal nerve stimulation attenuates acute lung injury following burn: The importance of the gut-lung axis

(2011) Michael J. Krzyzaniak et al.   SURGERY

Testosterone Depletion or Blockade in Male Rats Protects Against Trauma Hemorrhagic Shock-Induced Distant Organ Injury by Limiting Gut Injury and Subsequent Production of Biologically Active Mesenteric Lymph

(2011) Sharvil U. Sheth et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Acute Exacerbations in COPD and Their Control with Oral Immunization with Non-Typeable Haemophilus Influenzae

(2011) Robert L. Clancy et al.   Frontiers in Immunology

Antibiotic Exposure by 6 Months and Asthma and Allergy at 6 Years: Findings in a Cohort of 1,401 US Children

(2010) K. R. Risnes et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Innate and Adaptive Interleukin-17–producing Lymphocytes in Chronic Inflammatory Lung Disorders

(2010) Bart M. Vanaudenaerde et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intestinal Bacteria and the Regulation of Immune Cell Homeostasis

(2010) David A. Hill et al.   Annual Review of Immunology

Probiotics: progress toward novel therapies for intestinal diseases

(2010) Fang Yan et al.   CURRENT OPINION IN GASTROENTEROLOGY

Function of Mucosa-Associated Lymphoid Tissue in Antibody Formation

(2010) Per Brandtzaeg   IMMUNOLOGICAL INVESTIGATIONS

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma

(2010) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T Cell-Independent IgA Class Switch Recombination Is Restricted to the GALT and Occurs Prior to Manifest Germinal Center Formation

(2010) P. Bergqvist et al.   JOURNAL OF IMMUNOLOGY

Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients

(2010) A. Rehman et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Mucosal Immune System and Its Integration with the Mammary Glands

(2010) Per Brandtzaeg   JOURNAL OF PEDIATRICS

Adaptive immunity in the host–microbiota dialog

(2010) T Feng et al.   Mucosal Immunology

Therapeutic transplantation of the distal gut microbiota

(2010) A Khoruts et al.   Mucosal Immunology

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Early dietary exposures and feeding practices: role in pathogenesis and prevention of allergic disease?

(2010) S. Jennings et al.   POSTGRADUATE MEDICAL JOURNAL

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

(2010) Y. K. Lee et al.   SCIENCE

Oral Immunotherapy With Inactivated Nontypeable Haemophilus influenzae Reduces Severity of Acute Exacerbations in Severe COPD

(2009) Maharaj Kishore Tandon et al.   CHEST

The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis

(2009) Michael C Abt et al.   CURRENT OPINION IN GASTROENTEROLOGY

Recent Advances in Molecular Approaches to Gut Microbiota in Inflammatory Bowel Disease

(2009) Akira Andoh et al.   CURRENT PHARMACEUTICAL DESIGN

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology

Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis

(2009) D A Hill et al.   Mucosal Immunology

Mucosal Immunity: Induction, Dissemination, and Effector Functions

(2009) P. Brandtzaeg   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Lung Myeloid Dendritic Cells Coordinately Induce TH1 and TH17 Responses in Human Emphysema

(2009) M. Shan et al.   Science Translational Medicine

Specific probiotics alleviate allergic rhinitis during the birch pollen season

(2009) Arthur C Ouwehand et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Th17 Cells in Airway Diseases

(2008) Suzanne Traves et al.   CURRENT MOLECULAR MEDICINE

Neuroimmunology of the gut: physiology, pathology, and pharmacology

(2008) Shomron Ben-Horin et al.   CURRENT OPINION IN PHARMACOLOGY

Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation

(2008) Hisashi Ueta et al.   HEPATOLOGY

Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases

(2008) Charles Vanderpool et al.   INFLAMMATORY BOWEL DISEASES

Increased Risk of Both Ulcerative Colitis and Crohn’s Disease in a Population Suffering from COPD

(2008) Anders Ekbom et al.   LUNG

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

New visions for basic research and primary prevention of pediatric allergy: An iPAC summary and future trends

(2008) Eckard Hamelmann et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY