Primary Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling Pathways

Promotion of cancer cell stemness by Ras

(2021) Rohan Chippalkatti et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation and metabolic functions of mTORC1 and mTORC2

(2021) Angelia Szwed et al.   PHYSIOLOGICAL REVIEWS

Moonlighting of mitotic regulators in cilium disassembly

(2021) Cenna Doornbos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Limitations and opportunities in the pharmacotherapy of ciliopathies

(2021) Max Duong Phu et al.   PHARMACOLOGY & THERAPEUTICS

Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments

(2020) Kuo-Shyang Jeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Medulloblastoma cancer stem cells: molecular signatures and therapeutic targets

(2020) Hisham F Bahmad et al.   JOURNAL OF CLINICAL PATHOLOGY

Primary Cilia Mediate Wnt5a/β-catenin Signaling to Regulate Adipogenic Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Calcium Induction

(2020) Yun Kyung Bae et al.   Tissue Engineering and Regenerative Medicine

Stem Cell Signaling Pathways in the Small Intestine

(2020) Toshio Takahashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3

(2020) József Jászai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary cilia-dependent signaling is involved in regulating mesenchymal stem cell proliferation and pluripotency maintenance

(2020) Zhourui Ma et al.   JOURNAL OF MOLECULAR HISTOLOGY

Large-Scale Expansion of Human Mesenchymal Stem Cells

(2020) Muhammad Najib Fathi Bin Hassan et al.   Stem Cells International

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

(2020) Xiaobo Nie et al.   Frontiers in Oncology

Ciliopathies and the Kidney: A Review

(2020) Dominique J. McConnachie et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas

(2020) Julie Craft Van De Weghe et al.   JOURNAL OF CELL SCIENCE

Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma

(2019) François Kuonen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Three-dimensional architecture of epithelial primary cilia

(2019) Shufeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

(2019) Zhibin Liu et al.   Nature Communications

Primary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma

(2019) María Álvarez-Satta et al.   AGEING RESEARCH REVIEWS

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

(2019) Rongxuan Zhu et al.   Nature Communications

Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase

(2019) Andreas Ritter et al.   Stem Cell Research & Therapy

Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells via p53-Induced Quiescence

(2019) Jessica C. Garbern et al.   CIRCULATION

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

(2018) Daniel Zingg et al.   CANCER CELL

Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

(2018) Amandine Viau et al.   EMBO JOURNAL

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma

(2018) Yuriy V. Loskutov et al.   ONCOGENE

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

(2018) Issei S. Shimada et al.   Cell Reports

CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

(2018) Maren Mönnich et al.   Cell Reports

Primary Cilia Are Dysfunctional in Obese Adipose-Derived Mesenchymal Stem Cells

(2018) Andreas Ritter et al.   Stem Cell Reports

Neoplastic transformation of peribiliary stem cell niche in cholangiocarcinoma arisen in primary sclerosing cholangitis

(2018) Guido Carpino et al.   HEPATOLOGY

Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells

(2018) Zahra Kabiri et al.   JOURNAL OF CLINICAL INVESTIGATION

Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics

(2018) Donald Singer et al.   EMBO JOURNAL

Mixed signals from the cell's antennae: primary cilia in cancer

(2018) Thibaut Eguether et al.   EMBO REPORTS

TGF-β1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia

(2017) Sabrina Ehnert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer

(2017) Nadia B. Hassounah et al.   MOLECULAR CANCER RESEARCH

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL

(2017) E Hasanov et al.   ONCOGENE

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling

(2017) Vincent J. Guen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

(2017) Salih Gencer et al.   Science Signaling

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

(2017) Salih Gencer et al.   Science Signaling

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells

(2017) Mona Elsafadi et al.   Scientific Reports

Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate

(2016) Jiwon Jang et al.   CELL

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

(2016) Philippe Foerster et al.   DEVELOPMENT

Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain

(2016) Mary Gazea et al.   DEVELOPMENTAL BIOLOGY

INPP5E regulates phosphoinositide-dependent cilia transition zone function

(2016) Jennifer M. Dyson et al.   JOURNAL OF CELL BIOLOGY

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin

(2016) Tomohiro Kubo et al.   JOURNAL OF CELL SCIENCE

Motile and non-motile cilia in human pathology: from function to phenotypes

(2016) Hannah M Mitchison et al.   JOURNAL OF PATHOLOGY

Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway

(2016) Sicong Jiang et al.   Molecular Medicine Reports

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule doublets are double-track railways for intraflagellar transport trains

(2016) L. Stepanek et al.   SCIENCE

Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis

(2016) Lan B. Hoang-Minh et al.   Oncotarget

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass

(2016) Ge Guo et al.   Stem Cell Reports

TGFβ1 – induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner

(2016) Marie-Noëlle Labour et al.   Scientific Reports

Characterization of Cancer Stem Cells and Primary Cilia in Medulloblastoma

(2015) David Gate et al.   CNS & Neurological Disorders-Drug Targets

A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo

(2015) M. Stasiulewicz et al.   DEVELOPMENT

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Lineage specificity of primary cilia in the mouse embryo

(2015) Fiona K. Bangs et al.   NATURE CELL BIOLOGY

IFT–Cargo Interactions and Protein Transport in Cilia

(2015) Karl F. Lechtreck   TRENDS IN BIOCHEMICAL SCIENCES

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

(2015) Mirjana Kessler et al.   Nature Communications

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

Inhibition of Autophagy Suppresses Sertraline-Mediated Primary Ciliogenesis in Retinal Pigment Epithelium Cells

(2015) Eun Sung Kim et al.   PLoS One

A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity

(2014) N. Santos et al.   JOURNAL OF CELL SCIENCE

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

(2014) Qian He et al.   MOLECULAR BIOLOGY OF THE CELL

The Notch Pathway Is Important in Maintaining the Cancer Stem Cell Population in Pancreatic Cancer

(2014) Ethan V. Abel et al.   PLoS One

Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma

(2014) W. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphere Formation Permits Oct4 Reprogramming of Ciliary Body Epithelial Cells into Induced Pluripotent Stem Cells

(2014) Aiguo Ni et al.   STEM CELLS AND DEVELOPMENT

RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking

(2014) Robert J. Lake et al.   PLoS Genetics

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Mesenchymal stromal cell ciliogenesis is abrogated in response to tumor necrosis factor-α and requires NF-κB signaling

(2013) Amélie Vézina et al.   CANCER LETTERS

Gingivae Contain Neural-crest- and Mesoderm-derived Mesenchymal Stem Cells

(2013) X. Xu et al.   JOURNAL OF DENTAL RESEARCH

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

(2013) S. Bhogaraju et al.   SCIENCE

Morphological Differences of Primary Cilia Between Human Induced Pluripotent Stem Cells and Their Parental Somatic Cells

(2013) Bhavik B. Nathwani et al.   STEM CELLS AND DEVELOPMENT

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

(2013) Christian Alexandro Clement et al.   Cell Reports

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland

(2012) Elena García-Zaragoza et al.   DEVELOPMENTAL BIOLOGY

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

(2012) N. Qiu et al.   JOURNAL OF CELL SCIENCE

Characterization of an apical ceramide-enriched compartment regulating ciliogenesis

(2012) Qian He et al.   MOLECULAR BIOLOGY OF THE CELL

Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers

(2012) M K Y Siu et al.   ONCOGENE

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

(2011) Ellen J. Ezratty et al.   CELL

Ofd1, a Human Disease Gene, Regulates the Length and Distal Structure of Centrioles

(2010) Veena Singla et al.   DEVELOPMENTAL CELL

Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway

(2010) Alessandro Zullo et al.   HUMAN MOLECULAR GENETICS

Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues

(2010) Kun Yuan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

VHL Inactivation Induces HEF1 and Aurora Kinase A

(2010) J. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

(2009) Tracy-Ann Read et al.   CANCER CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

(2009) P. Huang et al.   DEVELOPMENT

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Primary Cilia Are Not Required for Normal Canonical Wnt Signaling in the Mouse Embryo

(2009) Polloneal Jymmiel R. Ocbina et al.   PLoS One

Cell Cycle-Dependent Ciliogenesis and Cancer

(2008) O. V. Plotnikova et al.   CANCER RESEARCH

Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming

(2008) Rudolf Jaenisch et al.   CELL

Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery

(2008) Enko N. Kiprilov et al.   JOURNAL OF CELL BIOLOGY

Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development

(2008) Guanghu Wang et al.   JOURNAL OF NEUROCHEMISTRY

Cilia and ciliopathies: From Chlamydomonas and beyond

(2008) JunMin Pan   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes

(2007) Sabrina Absalon et al.   MOLECULAR BIOLOGY OF THE CELL